Picrorhiza scrophulariiflora improves accelerated atherosclerosis through inhibition of redox-sensitive inflammation

Guo, Zhi Jian; Hou, Fan Fan; Liu, Shang Xi; Tian, Jing; Zhang, Wei Ru; Xie, Di; Zhou, Zhan Mei; Liu, Zhi Qiang; Zhang, Xun

doi:10.1016/j.ijcard.2008.12.102

Cited by 8 publications

(1 citation statement)

References 37 publications

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“…Previous studies have reported that glycosides are the key components responsible for their biological properties, such as immunomodulation, hepatoprotection, and cardiovascular protection. 11,13,[18][19][20][21] Subsequently, glycoside and non-glycoside fractions of P. scrophulariiflora were prepared using a macroporous adsorption resin D-101 column (Solarbio, Cat#M0041) and eluted successively with water and ethanol (water, 40%, and 100% ethanol), as previously reported. 22 The eluate of water, 40% ethanol, and 100% ethanol were concentrated and freezedried to yield the water fraction (WPS), 40% ethanol (glycoside fraction, GPS), and 100% ethanol fraction (nonglycoside fraction, NGPS) of P. scrophulariiflora, respectively.…”

Section: Preparation Of Different Fractions Of P Scrophulariifloramentioning

confidence: 99%

Network Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis

Wu¹,

Chang²,

Zhu³

et al. 2023

DDDT

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Purpose To explore the potential mechanism of glycosidic fraction of Picrorhiza scrophulariiflora Pennell (GPS) extract for the treatment of colitis using UPLC-QTOF-MS analysis, network pharmacology and experimental research. Methods The active components of GPS extract were identified by UPLC-QTOF-MS analysis and extracted their targets from the databases, which was used for network pharmacology analysis. Kyoto Encyclopedia of genes and genomes (KEGG) pathway analysis was performed to discover potential therapeutic mechanisms, and the network pharmacology results were then validated by in vivo and in vitro experiments. Results The results showed that GPS extract significantly alleviated the clinical signs of colitis, including body weight, disease activity index, colon shortening, and colon tissue damage, and inhibited the transcription and production of colonic IL-1β and IL-6 in DSS-induced colitis mice. In vitro, GPS extract also significantly suppressed nitric oxide (NO) production, iNOS expression, IL-1β and IL-6 transcription of LPS-activated RAW 264.7 cells. Network pharmacology integrated with experimental validation identified that GPS extract significantly suppressed Akt, p38, ERK, and JNK phosphorylation in vivo and in vitro, and luteolin, apocynin, caffeic acid, caffeic acid methyl ester, luteoloside, picroside II, aucubin, cinnamic acid, vanillic acid, and sweroside were the main components responsible for the anti-inflammatory effect of GPS. These findings demonstrate that the potential anti-inflammatory effect of GPS extract against colitis is achieved through suppressing PI3K/Akt and MAPK pathways, and that the abovementioned active components mainly exerted its anti-inflammatory effect. Conclusion The therapeutic effect of GPS extract on colitis is related to PI3K/Akt and MAPK pathways, which is a promising remedy for colitis therapy.

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Section: Preparation Of Different Fractions Of P Scrophulariifloramentioning

confidence: 99%

Network Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis

Wu¹,

Chang²,

Zhu³

et al. 2023

DDDT

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Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway

Oyagbemi

Omóbòwálé

Adejumobi

et al. 2020

European Journal of Pharmacology

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Hypolipidemic potential of Lepidogrammitis drymoglossoides in high-fat diet fed mice

Lei

Chen

Cai

et al. 2011

International Journal of Cardiology

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Picrorhiza scrophulariiflora improves accelerated atherosclerosis through inhibition of redox-sensitive inflammation

Cited by 8 publications

References 37 publications

Network Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis

Network Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis

Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway

Hypolipidemic potential of Lepidogrammitis drymoglossoides in high-fat diet fed mice

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