Pig as an experimental model for the study of snake venom induced local tissue necrosis

Imkhieo, Srisurat; Nakthong, Chowalit; Kespichayawattana, Wannapa; Sirimujalin, Rungtiva; Suwannaprapha, Parin; Ratanabanangkoon, Kavi

doi:10.1016/j.toxicon.2008.12.001

Cited by 3 publications

(1 citation statement)

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“…This includes studies on wound healing (Ansell et al, 2012;Jung et al, 2013;Sullivan et al, 2001), burns (Abdullahi et al, 2014;Sheu et al, 2014), transdermal penetration, delivery and toxicology (Barbero and Frasch, 2009;Godin and Touitou, 2007;Mahl et al, 2006;Simon and Maibach, 2000;Yu et al, 2013), infectious diseases (Mounsey et al, 2010;Rampton et al, 2013;San Mateo et al, 1999), radiation and UVB impact (Agay et al, 2010;Brozyna et al, 2009;Smirnova et al, 2014), snake venom (Imkhieo et al, 2009) and taser (Jenkins et al, 2013) assessments, as well as stem cell research (Hao et al, 2009;Zhao et al, 2012). The pig was also employed as a model for experimentally induced allergic contact dermatitis, revealing similarities to human with respect to clinical, histological and immunohistological features (Vana and Meingassner, 2000).…”

Section: Skin Structure and Advantages Of The Pig Modelmentioning

confidence: 99%

The immunology of the porcine skin and its value as a model for human skin

Summerfield¹,

Meurens

Ricklin³

2015

Molecular Immunology

402

262

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The porcine skin has striking similarities to the human skin in terms of general structure, thickness, hair follicle content, pigmentation, collagen and lipid composition. This has been the basis for numerous studies using the pig as a model for wound healing, transdermal delivery, dermal toxicology, radiation and UVB effects. Considering that the skin also represents an immune organ of utmost importance for health, immune cells present in the skin of the pig will be reviewed. The focus of this review is on dendritic cells, which play a central role in the skin immune system as they serve as sentinels in the skin, which offers a large surface area exposed to the environment. Based on a literature review and original data we propose a classification of porcine dendritic cell subsets in the skin corresponding to the subsets described in the human skin. The equivalent of the human CD141(+) DC subset is CD1a(-)CD4(-)CD172a(-)CADM1(high), that of the CD1c(+) subset is CD1a(+)CD4(-)CD172a(+)CADM1(+/low), and porcine plasmacytoid dendritic cells are CD1a(-)CD4(+)CD172a(+)CADM1(-). CD209 and CD14 could represent markers of inflammatory monocyte-derived cells, either dendritic cells or macrophages. Future studies for example using transriptomic analysis of sorted populations are required to confirm the identity of these cells.

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