Pigment epithelium‐derived factor as a new marker of metabolic syndrome in Caucasian population

Stejskal, David; Karpíšek, Michal; Švesták, Marek; Hejduk, Paulina; Sporová, L.; Kotolová, Hana

doi:10.1002/jcla.20360

Cited by 24 publications

(28 citation statements)

References 6 publications

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“…These findings go on line with another study performed by Stejskal et al (21) who concluded that PEDF is correlated with BMI and that PEDF is …”

Section: Discussionsupporting

confidence: 92%

“…The association of PEDF with MetS and its components has been verified in many previous studies (21) PEDF level was identified as an independent predictor for the development of MetS. (25) .…”

Section: Table1supporting

confidence: 61%

“…Antifibrogenic activity of intrahepatic PEDF has been demonstrated (18) . PEDF is secreted by fat cells as well, playing a role in the development of insulin resistance, metabolic syndrome, and liver steatosis (9,(19)(20)(21)(22)(23) .…”

Section: Discussionmentioning

confidence: 99%

“…In a study made by Stejskal et al (21) multivariate analysis revealed that no measured parameters were significant independent determinants of PEDF serum level. Evaluation of test validity characters using ROC curve defined a moderate diagnostic yield of PEDF with sensitivity 83.6 % and specificity 53.3% at a cut off value 53.5 µg/ml.…”

Section: Table1mentioning

confidence: 92%

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Serum pigment epithelium derived factor as a new marker in the metabolic syndrome

Sabry¹,

Shaaer²,

Hammady³

2017

Int J Recent Sci Res

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Background: Metabolic syndrome represents a cluster of related metabolic abnormalities, including central obesity, hyperglycemia, hypertension, dyslipidemia, and insulin resistance, with insulin resistance and central obesity in particular recognized as causative factors. Aim of the study: to determine serum level of Serum pigment epithelium derived factor (PEDF) and to examine whether PEDF serum level are associated with metabolic syndrome risk factor. Materials and Methods: The present study was conducted on 90 subjects subdivided into two groups. Patient group included 70 patients with metabolic syndrome attending the outpatient clinic in Benha University Hospital. and control group, this group included 20 apparently healthy individuals, Blood samples were drawn from all subjects to assess serum levels of PEDF, Hs-CRP, lipid profile, F.B.S, creatinine and uric acid. Results: PEDF level was significantly higher in patient group than control group, significant elevation of Hs-CRP, FBS, TG, LDL-cholesterol and uric acid in patient group versus control group and significant decrease of HDL-cholesterol in patient group versus control group. Significant positive correlation between PEDF (patient group) and each of the components of Metabolic syndromeas BMI,WC, LDL-cholesterol and total cholesterol, triglyceride, systolic &diastolic blood pressure and the accumulation of the number of this component collectively. Conclusion: Based on the evidence presented within the study, PEDF correlate significantly with metabolic syndrome and could provide a minimally-invasive mean for early detection and specific treatment of this disorder. Further research is encouraged to determine the efficacy of applying this biomarker fordiagnosis of metabolic syndrome.

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“…These findings go on line with another study performed by Stejskal et al (21) who concluded that PEDF is correlated with BMI and that PEDF is …”

Section: Discussionsupporting

confidence: 92%

Section: Table1supporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Table1mentioning

confidence: 92%

See 2 more Smart Citations

Serum pigment epithelium derived factor as a new marker in the metabolic syndrome

Sabry¹,

Shaaer²,

Hammady³

2017

Int J Recent Sci Res

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“…22 Increased PEDF levels are correlating with metabolic syndrome, type 2 diabetes, and abdominal fat distribution. 20,21,31 RBP4 was initially described to be associated with the metabolic syndrome. 9 It is well known that RBP4 is predominately produced and secreted from the adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

Combined Serum Proteomic and Metabonomic Profiling After Laparoscopic Sleeve Gastrectomy in Children and Adolescents

Oberbach

Bergen

Blüher

et al. 2012

Journal of Laparoendoscopic & Advanced Surgical Techniques

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A co‐occurrence of osteogenesis imperfecta type VI and cystinosis

Tucker

Nelson

Sirrs

et al. 2012

American J of Med Genetics Pt A

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Osteogenesis imperfecta type VI (OI type VI) is a rare autosomal recessive disorder caused by mutations in the SERPINF1 gene that encodes pigment epithelium-derived factor (PEDF). Cystinosis is an autosomal recessive lysosomal transport disorder caused by mutations in the CTNS gene. Both SERPINF1 and CTNS are located on chromosome 17p13.3. We describe an individual presenting with both OI type VI and cystinosis. The patient was diagnosed with cystinosis at the age of 11 months and OI type VI on bone biopsy at the age of 8 years. He has sustained over 30 fractures during his lifetime, and at the age of 19 years entered end-stage renal disease and subsequent renal transplant. An Affymetrix 6.0 array was used to look for areas of loss of heterozygosity on chromosome 17. Sequencing of the SERPINF1 and CTNS genes was performed, followed by quantitative PCR and Western blot of PEDF to characterize the identified mutation. A 6.58 Mb region of homozygosity was identified on the Affymetrix 6.0 array, encompassing both the SERPINF1 and CTNS genes. Sequencing of the genes identified homozygosity for a known pathogenic CTNS mutation and for a novel in-frame duplication in SERPINF1. Skin fibroblasts produced a markedly reduced amount of SERPINF1 transcript and PEDF protein. This patient has the concurrent phenotype of two rare recessive diseases, cystinosis and OI type VI. We identified for the first time an in-frame duplication in SERPINF1 that is responsible for the OI type VI phenotype in this patient.

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Pigment epithelium‐derived factor as a new marker of metabolic syndrome in Caucasian population

Abstract: Authors present that serum pigment epithelium derived factor (PEDF) is an independent marker of metabolic syndrome in Caucasianpopulation. PEDF was measured with new ELISA sandwich test. J. Clin. Lab. Anal. 24:17-19, 2010. (c) 2010 Wiley-Liss, Inc.

Cited by 24 publications

References 6 publications

Serum pigment epithelium derived factor as a new marker in the metabolic syndrome

Serum pigment epithelium derived factor as a new marker in the metabolic syndrome

Combined Serum Proteomic and Metabonomic Profiling After Laparoscopic Sleeve Gastrectomy in Children and Adolescents

A co‐occurrence of osteogenesis imperfecta type VI and cystinosis

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