Pigmentation Disorders in the Elderly

Armenta, Andrew M.; Henkel, Emily; Ahmed, Ammar M.

doi:10.1007/s40266-018-00633-w

Cited by 13 publications

(12 citation statements)

References 80 publications

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“…Validating the model’s potential to identify targetable drivers of age-related tissue pathology, hi T-bearing nude mice showed enhanced age-related pathology in skin and brain, specifically depigmentation and neuroinflammation ( Jurgens and Johnson, 2012 ; Lourbopoulos et al, 2015 ; Armenta et al, 2019 ; Rheins et al, 1986 ). Enhanced neuroinflammation in particular was found to require sustained presence of CD8 T cells in brain, as well as their fully intact pro-inflammatory function, as genetic knockout of the Perforin-1 gene in donor T cells eliminated their sustained presence in brain, while knockout of the IFNγ gene in donor T cells did not.…”

Section: Discussionmentioning

confidence: 99%

Functional recreation of age-related CD8 T cells in young mice identifies drivers of aging- and human-specific tissue pathology

Panwar

Jhun

Rentsendorj

et al. 2020

Mechanisms of Ageing and Development

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Mitigating effects of aging on human health remains elusive because aging impacts multiple systems simultaneously, and because experimental animals exhibit critical aging differences relative to humans. Separation of aging into discrete processes may identify targetable drivers of pathology, particularly when applied to human-specific features. Gradual homeostatic expansion of CD8 T cells dominantly alters their function in aging humans but not in mice. Injecting T cells into athymic mice induces rapid homeostatic expansion, but its relevance to aging remains uncertain. We hypothesized that homeostatic expansion of T cells injected into T-deficient hosts models physiologically relevant CD8 T cell aging in young mice, and aimed to analyze age-related T cell phenotype and tissue pathology in such animals. Indeed, we found that such injection conferred uniform age-related phenotype, genotype, and function to mouse CD8 T cells, heightened age-associated tissue pathology in young athymic hosts, and humanized amyloidosis after brain injury in secondary wild-type recipients. This validates a model conferring a human-specific aging feature to mice that identifies targetable drivers of tissue pathology. Similar examination of independent aging features should promote systematic understanding of aging and identify additional targets to mitigate its effects on human health.

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Section: Discussionmentioning

confidence: 99%

Functional recreation of age-related CD8 T cells in young mice identifies drivers of aging- and human-specific tissue pathology

Panwar

Jhun

Rentsendorj

et al. 2020

Mechanisms of Ageing and Development

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“…The involvement of PHBs in melanin production suggests that targeting PHBs may be a promising therapeutic approach for pigmentary disorders, which can be common in the elderly population ( Armenta et al, 2019 ). Melanogenin and melanogenin analogs also have potential as treatments against cancer since they can trigger apoptosis in tumor cells, such as melanoma cells ( Djehal et al, 2018 ).…”

Section: Prohibitin As a Therapeutic Targetmentioning

confidence: 99%

Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

Belser

Walker

2021

Front. Genet.

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A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins (PHB1 and PHB2) assemble at the mitochondrial inner membrane and are critical for mitochondrial homeostasis. In addition, prohibitins (PHBs) have diverse roles in cell and organismal biology. Here, we will discuss the role of PHBs in mitophagy, oxidative phosphorylation, cellular senescence, and apoptosis. We will also discuss the role of PHBs in modulating lifespan. In addition, we will review the links between PHBs and diseases of aging. Finally, we will discuss the emerging concept that PHBs may represent an attractive therapeutic target to counteract aging and age-onset disease.

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“…Melanocyte density is usually found to reduce 10-20% per decade in humans aged 30 years and older [46]. Despite this, hyperpigmentation is a Skin Pharmacol Physiol 2021;34:351-362 DOI: 10.1159/000514995 common phenomenon in the aging populations as a result of focal melanocyte proliferation and aggregation [47,48].…”

Section: Influence Of Demographic Background On Biophysical Parametersmentioning

confidence: 99%

Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use

Goh

Faisal

Ismail

2021

Skin Pharmacol Physiol

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Introduction: At present, there is a lack of baseline data on the facial skin biophysical profile of women in Malaysia. The implications related to the daily habits and facial skincare product use on the skin biophysical condition are, thus, unknown. In this study, we aim to evaluate facial skin biophysical parameters of Malaysian women and examine the influence of demographic characteristics, daily habits, and facial skincare product use on these parameters. Methods: Four skin biophysical parameters – transepidermal water loss (TEWL), melanin content, elasticity, and collagen intensity – were assessed on the cheek of the subjects (20–60 years). Demographic background, daily habits, and skincare product use were gauged through a survey. Only 197 from the 213 subjects recruited initially were used for analysis after the data were screened for normality. Results: The biophysical parameters were similar in different races, except a higher melanin content in Indian female individuals. Elasticity and collagen intensity reduced with age, while melanin content increased in the older age-groups. But no difference was observed in TEWL at different ages. Evaluating the influence of daily habits, we observed that exercise significantly lowered TEWL and increased melanin content, which may be associated with UV radiation exposure. Facial skincare products are popular among the female subjects (>85% users). Products with moisturizing, sunscreening, and other skincare functions (astringent, antiaging, and anti-wrinkle) were preferred by subjects of all ages. These product functions significantly improve skin elasticity and reduce melanin content in the young adults. While aged women recognized the importance of having an additional skin-lightening function in their skincare routine. Although the influence of individual skincare function on skin biophysical parameters was mostly positive, the alteration of these parameters varied at different ages. Conclusion: This is the first report of facial skin biophysical profile of Malaysian women. There is no difference among 3 major races saved for melanin content. This work demonstrated age-dependent influences on the biophysical parameters, except TEWL. The significance of skincare product use is well reflected in the improvement of these parameters at different age-groups based on individual skincare functions.

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Pigmentation Disorders in the Elderly

Cited by 13 publications

References 80 publications

Functional recreation of age-related CD8 T cells in young mice identifies drivers of aging- and human-specific tissue pathology

Functional recreation of age-related CD8 T cells in young mice identifies drivers of aging- and human-specific tissue pathology

Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use

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