Pigmented Lesion Pathology: What You Should Expect from Your Pathologist, and What Your Pathologist Should Expect from You

Fleming, Matthew G.

doi:10.1016/j.cps.2009.07.003

Cited by 6 publications

(5 citation statements)

References 155 publications

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“…In a typical setting, the lesion is clinically diagnosed as atypical enough to justify the biopsy, and referred to the pathologist who will give the "gold standard" diagnosis that will guide the behavior. In this sequence, several things can go wrong: the patient may not seek care while the lesion is curable, the physician to whom the patient initially resorts may fail to recognize the lesion as potentially malignant, the pathologist may misdiagnose the lesion, and the surgeon may act wrongly to the pathologist's report [20]. Communication among specialties is essential.…”

Section: Discussionmentioning

confidence: 99%

Surgery Associated with Radiotherapy for Treatment of Giant Squamous Cell Carcinoma in Hand

Mendes¹,

Ellinger²,

Souto³

et al. 2019

Arch Clin Med Case Rep

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Squamous cell carcinoma is the most common tumor in the hand, with actinic keratosis being its precursor lesion. It is a common tumor in light-skinned individuals with a history of excessive sun exposure and advanced age. It presents a wide variety of clinical forms, which can generate diagnostic doubt. The combination of clinical and pathological evaluations, together with detailed anamnesis, is the best way to achieve at the final diagnosis. The gold standard treatment for these tumors is surgical excision of the lesion with adequate safety margins; in some cases adjuvant radiotherapy is an excellent option. In this paper, we review the subject addressed and report the case of a patient with giant squamous cell carcinoma in one hand, with eight months of evolution, treated by surgical excision and adjuvant radiotherapy; the treatment was successful and preserved the motor function of the patient's hand.

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Section: Discussionmentioning

confidence: 99%

Surgery Associated with Radiotherapy for Treatment of Giant Squamous Cell Carcinoma in Hand

Mendes¹,

Ellinger²,

Souto³

et al. 2019

Arch Clin Med Case Rep

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“…If any of the prescreening questions were answered positively and any of the vision screening shapes were not correctly identified, then the participant was excluded from the study (n = 3). Participants were excluded from the study if they reported any of the following conditions, which may have prevented successful test calibration during the prescreening process: this included vision-related issues such as extreme tropias, phorias, static visual acuity of >20/400, nystagmus, cataracts or eyelash impediments or if they had consumed drugs or alcohol within 24 h of testing (n = 1) (Han et al, 2010;Holmqvist and Nystrom, 2011;Renard et al, 2015;Kooiker et al, 2016;Niehorster et al, 2017). Participants were also excluded if they were unable to pass a nine-point calibration sequence.…”

Section: Methodsmentioning

confidence: 99%

Oculomotor Behavior as a Biomarker for Differentiating Pediatric Patients With Mild Traumatic Brain Injury and Age Matched Controls

Hunfalvay¹,

Murray

Roberts

et al. 2020

Front. Behav. Neurosci.

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“…1 Throughout the world it affects thousands of people, not uncommonly with devastating results. The description of the diagnosis and treatment of melanoma and related neoplasms as “difficult and dangerous for all concerned 2 ” is unfortunately very accurate, and a false negative diagnosis of melanoma is the single most common reason for filing a malpractice claim against a pathologist. 3 A diagnosis of melanoma is commonly made via histological examination of clinically suspicious lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Melanoma is a significant cause of morbidity and mortality in the western world, with increasing incidence 1 . The diagnosis and treatment of melanoma and related neoplasms has been described as ‘difficult and dangerous for all concerned’, 2 and a false negative diagnosis of melanoma is the single most common reason for filing a malpractice claim against a pathologist 3 . A diagnosis of melanoma is made commonly via histological examination of clinically suspicious lesions.…”

Section: Introductionmentioning

confidence: 99%

Image and statistical analysis of melanocytic histology

Miedema¹,

Marron²,

Niethammer³

et al. 2012

Histopathology

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Aims We apply digital image analysis techniques to study selected types of melanocytic lesions. Methods and Results We used advanced digital image analysis to compare melanocytic lesions. All comparisons were statistically significant (p < 0.0001) and we highlight four: 1) melanoma to nevi, 2) melanoma subtypes to nevi, 3) severely dysplastic nevi to other nevi, and 4) melanoma to severely dysplastic nevi. We were successful in differentiating melanoma from nevi (ROC area 0.95) using image-derived features. While many features contribute to separation, analysis revealed features related to nuclear size, shape, and distance between nuclei to be most important. Dividing melanoma into subtypes, even greater separation was obtained (ROC area 0.98 for superficial spreading melanoma; 0.95 for lentigo maligna melanoma; and 0.99 for unclassified). Severely dysplastic nevi were best differentiated from conventional and mildly dysplastic nevi by differences in cellular staining qualities (ROC area 0.84). We found that melanoma were separated from severely dysplastic nevi by features related to cell shape and cellular staining qualities (ROC area 0.95). Conclusions We offer a unique perspective into the evaluation of melanocytic lesions and demonstrate a technological application with increasing prevalence, with potential use as an adjunct to traditional diagnosis in the future.

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Pigmented Lesion Pathology: What You Should Expect from Your Pathologist, and What Your Pathologist Should Expect from You

Cited by 6 publications

References 155 publications

Surgery Associated with Radiotherapy for Treatment of Giant Squamous Cell Carcinoma in Hand

Surgery Associated with Radiotherapy for Treatment of Giant Squamous Cell Carcinoma in Hand

Oculomotor Behavior as a Biomarker for Differentiating Pediatric Patients With Mild Traumatic Brain Injury and Age Matched Controls

Image and statistical analysis of melanocytic histology

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