Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury

Hardy, Pierre; Johnston, Karen; Beaumont, Louis De; Montgomery, David; Lecomte, Jacqueline M.; Soucy, Jean‐Paul; Bourbonnais, Daniel; Lassonde, Maryse

doi:10.1016/j.jns.2006.12.005

Cited by 27 publications

(16 citation statements)

References 41 publications

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“…The treatment leads to new vascular growth, vasoconstriction and hyperoxygenation, making it an effective therapy for a variety of ailments including delayed onset muscle soreness, 1,4 fibromyalgia, 20 complex regional pain syndrome, 7 and chronic brain injury. 5 Hyperbaric oxygen therapy has demonstrated efficacy in decreasing edema and hyperalgesia in inflammatory conditions. 5,15,18 The beneficial effects of hyperbaric oxygen therapy on inflammation make it an attractive treatment option for patients with chronic arthritis.…”

mentioning

confidence: 99%

“…5 Hyperbaric oxygen therapy has demonstrated efficacy in decreasing edema and hyperalgesia in inflammatory conditions. 5,15,18 The beneficial effects of hyperbaric oxygen therapy on inflammation make it an attractive treatment option for patients with chronic arthritis. Despite these indications for benefit, relatively few researchers have explored the effects of hyperbaric oxygen treatment on arthritis, and those that have provide mixed results.…”

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confidence: 99%

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Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Wilson

Toepfer

Senapati

et al. 2007

The Journal of Pain

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confidence: 99%

mentioning

confidence: 99%

Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Wilson

Toepfer

Senapati

et al. 2007

The Journal of Pain

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“…Several other case studies have been reported in which hyperbaric oxygen therapy resulted in a dramatic reduction or abolition of psychiatric symptoms in individuals suffering from postconcussive syndrome with and without associated PTSD features 17,30,31. Remarkably, hyperbaric oxygen therapy was effective in eliminating psychiatric symptoms when initiated six months to three years post-trauma.…”

Section: Resultsmentioning

confidence: 98%

Hyperbaric oxygen ameliorates worsening signs and symptoms of post-traumatic stress disorder

Eovaldi

Zanetti²

2010

NDT

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Hyperbaric oxygen therapy at 2.4 atmospheric pressure absolutes for 90 minutes per day ameliorated the signs and symptoms of agitation, confusion, and emotional distress in a 27-year-old male seven days following a traumatic accident. Hyperbaric oxygen was used to treat the patient’s crush injury and underlying nondisplaced pelvic fractures which were sustained in a bicycle versus automobile traffic accident. Its effect on the patient’s neuropsychiatric symptoms was surprising and obvious immediately following the initial hyperbaric oxygen treatment. Complete cognitive and psychiatric recovery was achieved by the seventh and final hyperbaric oxygen treatment. We propose that hyperbaric oxygen was effective in improving the patient’s neuropsychiatric symptoms by reducing cerebral oxidative stress, inflammation, vasogenic edema, and hippocampal neuronal apoptosis. Further investigation into the use of hyperbaric oxygen as a novel therapy for the secondary prevention of post-traumatic stress disorder that often accompanies post-concussive syndrome may be warranted. We acknowledge that hyperbaric oxygen therapy has been shown to have a strong placebo effect on neurologic and psychiatric diseases.

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“…However, this study did not specify the pure oxygen effects on human brain activity. In a single brain-injury patient study, the P300 event-related potential was noted to be enhanced at the damaged hemisphere after 20-60 sessions of treatments under hyperbaric condition (Hardy et al 2007). This single subject report provides bare testimony to the effects of oxygen on the human brain.…”

Section: Introductionmentioning

confidence: 96%

Effect of Homobaric Pure Oxygen on Sensory Gating in the Human Brain

Yang

et al. 2011

Brain Topogr

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Sensory gating, a viable function of the brain, is an adaptive mechanism to prevent overstimulation of nervous system. The aim of this study was to examine the effect of homobaric pure (i.e. 100%) oxygen on the human brain at different periods of inhalation. EEG was recorded while an auditory paired-click sensory gating test was conducted during 4 study periods: before inhalation of pure oxygen (Before), inhalation of 100% oxygen (air in control group) for 20 min (Oxy20) and 50 min (Oxy50), 30 min after oxygen (air in control group) inhalation (After). Each of the auditory stimuli elicited 4 clear peaks at 20, 39, 55 and 100 ms in ERPs, demonstrating that sensory gating is a multi-stage process. Comparing the S1-S2 differences of field potentials between two groups, significant experimental effects (P < 0.05-0.01) were shown at Oxy50 and After periods mainly at the 20 and 100 ms peak in ERPs. Pure oxygen was experimentally shown, for the first time, to affect the human brain activation, at the beginning of early P20 sensory cortical activation and late N100 auditory perception. The effect found in this study shall encourage further investigation on the oxygen treatment in human brain.

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Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury

Cited by 27 publications

References 41 publications

Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Hyperbaric oxygen ameliorates worsening signs and symptoms of post-traumatic stress disorder

Effect of Homobaric Pure Oxygen on Sensory Gating in the Human Brain

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