Pilot Experimental Study on the Effect of Arginine, Glutamine, and β‐Hydroxy β‐Methylbutyrate on Secondary Wound Healing

Bozkırlı, Bahadır Osman; Gündoğdu, Rıza Haldun; Ersoy, Eren; Lortlar, Neşe; Yıldırım, Zühal; Temel, Hande; Oduncu, Mehmet; Karakaya, Jale

doi:10.1177/0148607113520433

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…A recent experimental research by the authors of the present study revealed no benefit of the supplementation of this amino acid mixture on the secondary healing of experimental wounds in otherwise healthy rats 7 . In the mentioned study, however, the wounds were acute, and the subjects had no metabolic impairments, unlike the patients in the clinical trials that revealed benefits of the supplement in the closure of diabetic ulcers.…”

Section: Introductioncontrasting

confidence: 60%

“…The difference between the 2 groups in wound sizes was significant beginning on the 10th day and still apparent on the 14th day. In a previous trial by the authors of this article, it was demonstrated that this mixture of amino acids was not effective in accelerating the healing of acute experimental nonischemic wounds 7 . This may suggest that the enhancement in the treatment group in the present study may rather be attributed to the efficacy of this amino acid combination in wound healing only in the presence of a factor that impairs wound healing, such as ischemia.…”

Section: Discussionmentioning

confidence: 52%

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Mixture of Arginine, Glutamine, and β‐hydroxy‐β‐methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats

Gündoğdu

Temel

Bozkırlı

et al. 2016

J Parenter Enteral Nutr

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Section: Introductioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 52%

Mixture of Arginine, Glutamine, and β‐hydroxy‐β‐methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats

Gündoğdu

Temel

Bozkırlı

et al. 2016

J Parenter Enteral Nutr

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“…It is postulated that this might occur via a metabolic intermediary, P5C (35). Reports have demonstrated the benefit of glutamine supplementation alone on wound collagen synthesis and accumulation in primary or secondary (36) wounds. Specifically, a study of air leak pressures after deliberate pulmonary laceration in a group of Wistar albino rats indicated that rats receiving glutamine supplementation had higher air leak pressures than control animals, and that these animals also had higher levels of immature collagen, as demonstrated by histopathology (37).…”

Section: Clinical and Preclinical Data Examining Nutrient Supplementamentioning

confidence: 99%

Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing

Albaugh¹,

Mukherjee²,

Barbul³

2017

The Journal of Nutrition

144

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Wound healing is a complex process marked by highly coordinated immune fluxes into an area of tissue injury; these are required for re-establishment of normal tissue integrity. Along with this cascade of cellular players, wound healing also requires coordinated flux through a number of biochemical pathways, leading to synthesis of collagen and recycling or removal of damaged tissues. The availability of nutrients, especially amino acids, is critical for wound healing, and enteral supplementation has been intensely studied as a potential mechanism to augment wound healing-either by increasing tensile strength, decreasing healing time, or both. From a practical standpoint, although enteral nutrient supplementation may seem like a reasonable strategy to augment healing, a number of biochemical and physiologic barriers exist that limit this strategy. In this critical review, the physiology of enteral amino acid metabolism and supplementation and challenges therein are discussed in the context of splanchnic physiology and biochemistry. Additionally, a review of studies examining various methods of amino acid supplementation and the associated effects on wound outcomes are discussed.

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“…Hydroxyproline content measures collagen turnover throughout the wound-healing process and assesses wound-healing therapy quality 42 , 44 , 45 . The hydroxyproline concentration in the 10% Mattan tailam nanogel treated groups was significantly greater than in the standard formulation and Nitrofurazone groups.…”

Section: Discussionmentioning

confidence: 99%

Formulation, Characterization, and Evaluation of Wound Healing Potency of a Novel Mattan tailam Nanogel Based on a Famous Traditional Siddha Formula

Sakthiganapathi¹,

Yoganandam²,

Gopal³

2022

AJMB

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Background: The Mattan tailam mixture has been extensively used to heal ulcerous wounds in traditional Siddha practice. The present study aimed to synthesize a Mattan tailam nanogel and evaluate the enhancement of wound healing potential in an experimental wound model. Methods: Mattan tailam nanogel was synthesized using the high-energy milling approach, and characterization of nanogel and potency of wound healing was investigated. The novelty of this study was the nanogel preparation of Mattan tailam. Results: As expected, a synthesized novel nanogel of Mattan tailam has a distinct, prominent peak with a spherical form, is negatively charged and has an average particle size of 20–30 nm. Mattan tailam nanogel treated rats showed a remarkable reduction (p<0.001) in the wound area. On the 16th day, 10% Mattan tailam nanogel treatment resulted in a higher percentage of wound contraction. The 10% Mattan tailam nanogel group exhibited a faster epithelialization time (14.33 days) and a greater hydroxyproline concentration than the others. The topical application of 10% Mattan tailam nanogel increased tensile strength, signifying a better therapeutic indication. Conclusion: The present findings prove that polyherbal Mattan tailam nanogel formulation significantly improves collagen production, wound contraction, and tensile strength.

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Pilot Experimental Study on the Effect of Arginine, Glutamine, and β‐Hydroxy β‐Methylbutyrate on Secondary Wound Healing

Abstract: Diet supplemented with arginine, glutamine, and β-hydroxy β-methylbutyrate is not beneficial in enhancing secondary healing of open wounds in rats. Further research regarding this topic is warranted.

Cited by 7 publications

References 27 publications

Mixture of Arginine, Glutamine, and β‐hydroxy‐β‐methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats

Mixture of Arginine, Glutamine, and β‐hydroxy‐β‐methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats

Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing

Formulation, Characterization, and Evaluation of Wound Healing Potency of a Novel Mattan tailam Nanogel Based on a Famous Traditional Siddha Formula

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