Pilot study on photodynamic therapy for acne using indocyanine green and diode laser

Kim, Beom Joon; Lee, Ho Gyun; Woo, Seung Man; Youn, Jai Il; Suh, Dae Hun

doi:10.1111/j.1346-8138.2008.00580.x

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Other topical photosensitizers, which have been studied less extensively, include indocyanine green (or methylene blue) and indole-3-acetic acid 32,33,108–113. Indole-3-acetic acid in particular may have an important role in clinical practice, primarily because patients receiving indole-3-acetic acid for acne experience less pain.…”

Section: Pdt In Inflammatory Diseasesmentioning

confidence: 99%

Current evidence and applications of photodynamic therapy in dermatology

Wan¹,

Lin²

2014

CCID

117

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In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

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Section: Pdt In Inflammatory Diseasesmentioning

confidence: 99%

Current evidence and applications of photodynamic therapy in dermatology

Wan¹,

Lin²

2014

CCID

117

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“…21 The phototoxic effect of ICG-enhanced therapy has been studied in various fields. [22][23][24][25][26][27][28] However, the strong binding of plasma proteins with ICG and its subsequent rapid clearance by the liver 21 results in no tumor selectivity after systemic administration.…”

mentioning

confidence: 99%

Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis

Funayama

Sakane

Abe

et al. 2012

Photomedicine and Laser Surgery

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Objective: The purpose of this study was to investigate the phototoxic effects of photodynamic therapy (PDT) with indocyanine green (ICG) and near-infrared light irradiation on rat mammary adenocarcinoma cells, and its therapeutic efficacy in a rat model of spinal metastasis. Background data: Although PDT has been successfully used as a non-radiation treatment for many malignancies, it has not yet been clinically applied for treating spinal metastasis. Methods: For the phototoxicity study, CRL-1666 cells were treated with PDT and cell viability was measured by WST-1 assay. For the efficacy study, 26 female Fischer 344 rats with spinal metastasis in the L6 vertebra were divided into three treatment groups: PDT with local injection of ICG (9 rats), PDT with systemic injection of ICG (10 rats), and no treatment or control (7 rats). Both the PDT groups received near-infrared light irradiation with a total energy of 10 J (1 W for 10 sec). The light was delivered directly through a single silica probe which was set on the left side of the L6 vertebral body. Hindlimb motor function was monitored according to the Basso-Beattie-Bresnahan (BBB) scale. Further, the observation periods were calculated to determine the survival time. Results: The PDT exerted immediate and persistent phototoxic effects. Furthermore, the PDT with local injection of ICG as well as systemic injection of ICG delayed the deterioration of paralysis and prolonged the observation period. Conclusions: PDT with ICG injection and near-infrared light irradiation could be an effective local adjuvant treatment for spinal metastasis.

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“…We did not allow the topical or systemic agent for acne during the treatment and follow-up period of ICG-PDT; however, all subjects showed improvement with only ICG-PDT. Therefore, repetitive treatment sessions of ICG-PDT can According to the previous study by Kim et al, 19 both treatment sites using the diode laser combined with ICG and diode laser alone presented an improvement in the acne. The diode laser itself might improve the acne lesions.…”

Section: Discussionmentioning

confidence: 89%