Pilot study on reflectance confocal microscopy imaging of lichen planus: a real‐time, non‐invasive aid for clinical diagnosis

Moscarella, Elvira; González, Salvador; Agozzino, Marina; Sánchez-Mateos, J.L. Santiago; Panetta, Chiara; Contaldo, María; Ardigò, Marco

doi:10.1111/j.1468-3083.2011.04279.x

Cited by 51 publications

(55 citation statements)

References 13 publications

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“…In 2012 Moscarella et al [15] published the results of a pilot study of the RCM efficacy in the diagnosis of lichen planus (LP). Large polygonal cells containing grainy cytoplasm, a feature corresponding to hypergranulosis in histology, were found within the stratum granulosum.…”

Section: Lichen Planusmentioning

confidence: 99%

Review paper The use of reflectance confocal microscopy in selected inflammatory skin diseases

Białek-Galas¹,

Wielowieyska-Szybińska²,

Dyduch³

et al. 2015

pjp

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Reflectance confocal microscopy is a modern, non-invasive diagnostic method that enables real-time imaging of the epidermis and upper layers of the dermis with nearly histological precision and high contrast. The application of this technology to skin imaging during the last years has resulted in progress of dermatological diagnosis, providing virtual access to living skin, without the need for conventional histopathology. The presented method potentially has broad application in the diagnosis of skin diseases. This article provides a summary of the latest reports and previous achievements in the field of reflectance confocal microscopy. General characteristics of confocal images in selected inflammatory skin diseases are presented.

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Section: Lichen Planusmentioning

confidence: 99%

Review paper The use of reflectance confocal microscopy in selected inflammatory skin diseases

Białek-Galas¹,

Wielowieyska-Szybińska²,

Dyduch³

et al. 2015

pjp

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“…Keratinocyte necrosis and apoptotic keratinocytes are considered to be responsible for the vacuolar degeneration of the DEJ seen in interface dermatitis [4]. Intraepidermal necrotic keratinocytes have been described with RCM in lichen planus [2] and lupus erythematosus [3] as mildly bright, polygonal structures larger than surrounding keratinocytes. However, the cellular changes we observed at the DEJ, and which we correlated to basal cell vacuolization, have not been described in these previous pilot studies.…”

Section: Figmentioning

confidence: 99%

“…Little literature is available regarding the in vivo reflectance confocal microscopy (RCM) features of interface dermatitis. To date, two pilot studies have focused on the RCM criteria of lichen planus [2] and discoid lupus erythematosus [3]. Interface changes have mainly been described in terms of architectural alteration of the DEJ.…”

Section: Figmentioning

confidence: 99%

Signet Ring-Like Cells: A New Reflectance Confocal Microscopy Clue of Interface Dermatitis Correlated to Basal Cell Vacuolization in Histopathology

Amini‐Adlé¹,

Debarbieux²,

Perier‐Muzet³

et al. 2015

Dermatology

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“…Starting from previous experience of RCM in psoriasis [4], lichen planus [6], contact dermatitis [7], and other inflammatory skin diseases [8,9], high correspondence between confocal features and optical histology has been widely demonstrated [10,11]. No previous description of SD using RCM, and the identification of specific criteria useful for its differential diagnosis with PP, has been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Reflectance Confocal Microscopy Features of Seborrheic Dermatitis for Plaque Psoriasis Differentiation

et al. 2014

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Background: Plaque psoriasis (PP) and seborrheic dermatitis (SD) are chronic inflammatory skin diseases with similar clinical and pathological features. Differential diagnosis can be difficult, especially when particular skin areas of the face are involved. Reflectance confocal microscopy (RCM) has been demonstrated to be useful for ‘real-time' diagnosis of skin inflammatory diseases. Objective: To define distinctive confocal criteria of SD and to evaluate the usefulness of this technique for noninvasive differential diagnosis with PP. Methods: A total of 40 patients affected by PP and 19 patients by SD involving the face were recruited and subjected to RCM evaluation. Univariate and adjusted odds ratios were calculated. Discriminant functions were used to plot ROC curves. Results: The results disclosed specific patterns for SD and PP. The following distinctive confocal features for SD have been identified: spongiosis, dermal inflammation and horizontal orientation of dilated blood vessels. Conclusion: SD has a specific and easily recognizable confocal pattern supporting clinical differentiation with PP.

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Pilot study on reflectance confocal microscopy imaging of lichen planus: a real‐time, non‐invasive aid for clinical diagnosis

Cited by 51 publications

References 13 publications

Review paper The use of reflectance confocal microscopy in selected inflammatory skin diseases

Review paper The use of reflectance confocal microscopy in selected inflammatory skin diseases

Signet Ring-Like Cells: A New Reflectance Confocal Microscopy Clue of Interface Dermatitis Correlated to Basal Cell Vacuolization in Histopathology

Reflectance Confocal Microscopy Features of Seborrheic Dermatitis for Plaque Psoriasis Differentiation

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