Pineal anlage tumor: a case report and the literature review

Ying, Zesheng; Ge, Ming; Yang, Wei; Cai, Yingjie; Zhang, Nan

doi:10.1007/s00381-022-05763-6

Cited by 1 publication

(1 citation statement)

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“…Furthermore, patient stratification according to tumor molecular characteristics may show that optimal treatment strategies differ by molecular subgroup, but due to the lack of data this remains to be seen. As we sought to include tumors classified by the World Health Organization in the initial screening for this review, relatively rare entities, such as pineal anlage tumors [ 73 , 74 ], were not included. It is also possible that with contemporary molecular neuropathologic techniques, some of the patients included in the current study, especially older adults reported in studies prior to 2007, would have had their tumors reclassified [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

Nandoliya,

Sadagopan,

Thirunavu

et al. 2023

Cancers

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Most of the literature on pineoblastoma consists of case reports and single-institution series. The goal of this systematic review and individual patient data (IPD) analysis was to summarize the existing literature, identify factors associated with overall survival (OS), and provide a contemporary update on prognosis for patients with pineoblastoma. Forty-four studies were identified with 298 patients having IPD. Kaplan–Meier analyses were used to report survival outcomes based on age, tumor metastases, extent of resection (EOR), adjuvant therapy, and publication year. Cox regression was performed to identify independent predictors of time to mortality. Multivariable recursive partitioning analysis was used to identify the most important subgroups associated with mortality. Patients were classified based on publication year before and after the last systematic review on this topic (pre-2012 and 2012 onwards) and compared using univariate and multivariable analyses. This study demonstrates that EOR less-than-gross total resection, metastatic presentation, adjuvant chemotherapy without radiation, and tumor presentation in children less than three years old are associated with poorer prognosis. Since 2012, the 5-year actuarial OS has improved from 32.8% to 56.1%, which remained significant even after accounting for EOR, age, and adjuvant therapy. Pineoblastoma remains a severe rare disease, but survival outcomes are improving.

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Section: Discussionmentioning

confidence: 99%