Pineal Parenchymal Tumors

Maarouf, Mohammad; Majdoub, Faycal El; Bührle, Christian; Voges, Jürgen; Lehrke, Ralph; Köcher, Martin; Hunsche, S.; Treuer, Harald; Sturm, Volker

doi:10.1007/s00066-010-2096-3

Cited by 24 publications

(5 citation statements)

References 42 publications

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“…However, we must scrutinize whether our strict inclusion criteria might have contributed to the obtained favorable results. However, previous reports using IBT for the treatment of brain tumors have also shown its efficacy [10,[13][14][15][16]. Stereotactic interstitial brachytherapy for the treatment of oligodendroglial brain tumors [6,[35][36][37].…”

Section: Discussionmentioning

confidence: 99%

“…A total of 67 patients underwent IBT for the treatment of intracranial oligodendroglial tumors between January 1991 and December 2010 in our department. In addition, patients with an OG WHO III without receiving external fractionated irradiation prior to IBT obtained an adjuvant external fractionated irradiation boost with a median total dose of 25.2 Gy (range 20-36 Gy) according to our schedule for gliomas [9,10]. Four patients were lost to follow-up; hence, 63 patients (male/female ratio 30/33; median age 43.3 years, range 20.8-63.4 years) were evaluated in this study.…”

Section: Patientsmentioning

confidence: 99%

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Stereotactic interstitial brachytherapy for the treatment of oligodendroglial brain tumors

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Stereotactic interstitial brachytherapy for the treatment of oligodendroglial brain tumors

et al. 2015

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“…Complete remission rate was 72% and partial remission rate 28%. Maarouf et al concluded that iodine-125 seeds are efficient and safe and an attractive alternative to microsurgery [165]. All in all, iodine-125 brachytherapy treatment with a low dose rate seems to be an attractive, minimally invasive treatment option of these rare tumour entities of the pineal region.…”

Section: Reviewmentioning

confidence: 99%

Iodine-125 brachytherapy for brain tumours - a review

et al. 2012

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Iodine-125 brachytherapy has been applied to brain tumours since 1979. Even though the physical and biological characteristics make these implants particularly attractive for minimal invasive treatment, the place for stereotactic brachytherapy is still poorly defined.An extensive review of the literature has been performed, especially concerning indications, results and complications. Iodine-125 seeds have been implanted in astrocytomas I-III, glioblastomas, metastases and several other tumour entities. Outcome data given in the literature are summarized. Complications are rare in carefully selected patients.All in all, for highly selected patients with newly diagnosed or recurrent primary or metastatic tumours, this method provides encouraging survival rates with relatively low complication rates and a good quality of life.

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“…Of the 2701 articles retrieved in the search, 44 studies with IPD on 298 patients with pineoblastoma were included in the systematic review ( Table 1 ) [ 5 , 6 , 8 , 9 , 10 , 11 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Figure 1 presents the PRISMA flowchart for this systematic review [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

Nandoliya,

Sadagopan,

Thirunavu

et al. 2023

Cancers

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Most of the literature on pineoblastoma consists of case reports and single-institution series. The goal of this systematic review and individual patient data (IPD) analysis was to summarize the existing literature, identify factors associated with overall survival (OS), and provide a contemporary update on prognosis for patients with pineoblastoma. Forty-four studies were identified with 298 patients having IPD. Kaplan–Meier analyses were used to report survival outcomes based on age, tumor metastases, extent of resection (EOR), adjuvant therapy, and publication year. Cox regression was performed to identify independent predictors of time to mortality. Multivariable recursive partitioning analysis was used to identify the most important subgroups associated with mortality. Patients were classified based on publication year before and after the last systematic review on this topic (pre-2012 and 2012 onwards) and compared using univariate and multivariable analyses. This study demonstrates that EOR less-than-gross total resection, metastatic presentation, adjuvant chemotherapy without radiation, and tumor presentation in children less than three years old are associated with poorer prognosis. Since 2012, the 5-year actuarial OS has improved from 32.8% to 56.1%, which remained significant even after accounting for EOR, age, and adjuvant therapy. Pineoblastoma remains a severe rare disease, but survival outcomes are improving.

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Pineal Parenchymal Tumors

Cited by 24 publications

References 42 publications

Stereotactic interstitial brachytherapy for the treatment of oligodendroglial brain tumors

Stereotactic interstitial brachytherapy for the treatment of oligodendroglial brain tumors

Iodine-125 brachytherapy for brain tumours - a review

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

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