Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion

Abstract

Pinocembrin showed a neuroprotective effects through antioxidant, anti-inflammatory and antiapoptotic mechanisms.

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

“…Pinocembrin (Fig. 1A), one of the primary flavonoids from Pinus heartwood and Eucalyptus, has been reported to have a variety of pharmacological activities such as anti-inflammatory and antioxidant activities (Saad et al, 2015). Previous studies showed that pinocembrin inhibited LPS-induced TNF-α, IL-1β and IL-6 production in RAW264.7 cells in vitro (Soromou et al, 2012).…”

Revisiting Greek Propolis: Chromatographic Analysis and Antioxidant Activity Study

“…In this regard, many research groups have presented reviews and original reports on the beneficial effect on human health of many of its constituents [8–14]. In this context, some of its components have been shown to attenuate apoptosis in rat models (for pinocembrin see [15]). Caffeic acid phenethyl ester (CAPE) is an exemplary bioactive component of propolis, exhibiting a diversity of bioactivities, such as anti-tumor effects in pre-clinical models of human breast cancer or inhibition of growth of breast cancer stem cells [16,17].…”

The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review

“…In a recent animal study, pinocembrin ameliorated cerebral damage caused by global cerebral ischemia-reperfusion. These neuroprotective effects (Lin et al, 2010) were attributed to pinocembrin suppressing damaging biomarkers including oxidative stress and inflammation (Saad et al, 2015). Another mechanism may be through improving brain edema, reduced BBB permeability and improve cerebral blood flow (Meng et al, 2011).…”