Pinocytosis

Holter, Heinz

doi:10.1016/s0074-7696(08)62738-2

Cited by 159 publications

(47 citation statements)

References 17 publications

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“…In this connection, the abnormal T-system proliferation in both cultured and atrophied muscle might be somehow associated with the absence of innervation. It is possible that proteins or other substances in our culture medium stimulate multiple caveolation in the muscle cells much as they have been shown to stimulate pinocytosis in amebae (see Holter, 1959 and and in some mammalian cells (Barrnett and Ball, 1960). The overproduction of the T-system tubules in denervated muscle fibers (and in rather later stages after denervation, Pellegrino and Franzini, 1963) might be explained by assuming that some mate-FIGuRE 13 Ferritin experiment.…”

Section: Discussionmentioning

confidence: 99%

Formation of Elaborate Networks of T-System Tubules in Cultured Skeletal Muscle With Special Reference to the T-System Formation

Ishikawa

1968

The Journal of Cell Biology

238

109

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Muscle cells, cultured for 1-28 days from I 1-day chick embryo breast muscles, often show elaborate, three-dimensional networks of a membranous system. The network consists of tubular units which are quite regularly arranged. The tubular units composing the network are accessible to ferritin particles suspended in the culture medium; this suggests continuity with the extracellular fluid. These networks can be regarded as a special morphological elaboration of the T-system tubules. Such network formations can be seen much more often in well-developed myotubes. The networks usually exhibit a hexagonal pattern, which is formed of tubular units of a constant diameter. However, some early myotubes contain tetragonal networks, which are composed of spherical pockets with channels of lesser diameter connecting the pockets. Networks are also observed which probably represent a transitional form between these two patterns. Myotubes show many inpocketings of the sarcolemma similar to what are commonly referred to as caveolae or micropinocytotic vesicles. The similarity in configuration and dimension of the tubular units of the network to the caveolae leads to the plausible suggestion that repeated caveola-formation from the sarcolemma or T-system tubule may result in formation of these networks. In this connection, a possible mechanism of the T-system tubule formation is discussed.

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Section: Discussionmentioning

confidence: 99%

Formation of Elaborate Networks of T-System Tubules in Cultured Skeletal Muscle With Special Reference to the T-System Formation

Ishikawa

1968

The Journal of Cell Biology

238

109

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“…Pinocytosis is an active process stimulated by substances, including salts, that bind on to the mucoid coating of the cells (Holter, 1959(Holter, , 1963. Oxygen uptake is not increased during pinocytosis (Holter, 1963) and it is likely that, as in phagocytosis (Takikawa, Ohta & Hibino, 1963) As regards the part played by bicarbonate, the carbonic anhydrase inhibitor acetazolamide did not affect vacuolation, though concentrations of the same order practically abolish bicarbonate output by the pancreas (Birnbaum & Hollander, 1953).…”

Section: Discussionmentioning

confidence: 99%

The experimental production of watery vacuolation in the acinar cells of the submandibular gland

Tapp¹,

Trowell²

1967

The Journal of Physiology

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SUMMARY1. Watery vacuolation in the acinar cells of the rat submandibular gland is described. The vacuoles are cytoplasmic, membrane-walled, and 2-20 It in diameter. They are visible in living cells and appear to contain a watery fluid.2. Vacuolation occurred regularly in the following experimental situations: (1) in vitro-under anoxic conditions (2) post mortem-in animals killed by anoxia, and (3) in vivo-during secretion.3. By in vitro experiments it was shown that vacuolation occurs only when the cells are both anoxic and exposed to an excess of extracellular fluid containing calcium and bicarbonate. It was further shown that vacuolation is reversible in oxygen and that both its development and recovery are temperature dependent.4. Evidence is presented that the vacuolation is not a degenerative or necrotic change, that it is accompanied by the entry of fluid into the cells, and that it is not caused by simple osmosis.5. The mechanism of vacuolation and its possible relation to secretion are discussed. It is suggested that vacuolation represents an imbalance between the ingestion and secretion of water and salts.6. Similar vacuoles, apparently produced by the same mechanism, were observed in the acinar cells of the parotid gland and the pancreas of the rat.7. The close similarity of this vacuolation to that previously described in rat liver cells was noted.

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“…Finally, as an echo from the early days of pinocytosis and its sequels at Carlsberg Laboratorium, I was interested to notice, among the first references in a paper from 1983 "Phagocytepathogenic microbe interactions" (59), two reviews on pinocytosis, the first by HOLTER from 1959 (32), the second by a former co-worker (14).…”

Section: Resultsmentioning

confidence: 99%

The early days of pinocytosis

Chapman-Andresen

1984

Carlsberg Res. Commun.

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Pinocytosis

Cited by 159 publications

References 17 publications

Formation of Elaborate Networks of T-System Tubules in Cultured Skeletal Muscle With Special Reference to the T-System Formation

Formation of Elaborate Networks of T-System Tubules in Cultured Skeletal Muscle With Special Reference to the T-System Formation

The experimental production of watery vacuolation in the acinar cells of the submandibular gland

The early days of pinocytosis

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