Pipeline for contraceptive development

Abstract

The high rates of unplanned pregnancy reflect unmet need for effective contraceptive methods for women, especially for individuals with health risks such as obesity, diabetes, hypertension, and other conditions that may contraindicate use of an estrogen-containing product. Improvements in safety, user convenience, acceptability and availability of products remain important goals of the contraceptive development program. Another important goal is to minimize the impact of the products on the environment. Development of new methods for male contraception has the potential to address many of these issues with regard to safety for women who have contraindications to effective contraceptive methods but want to protect against pregnancy. It also will address a huge unmet need for men who want to control their fertility. Products under development for men would not introduce eco-toxic hormones in the waste water. Investment in contraceptive research to identify new products for women has been limited in the pharmaceutical industry relative to investment in drug development for other indications. Pharmaceutical R&D for male contraception was active in the 1990’s but was abandoned over a decade ago. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported a contraceptive development program since 1969. Through a variety of programs including research grants and contracts, NICHD has developed a pipeline of new targets/products for male and female contraception. A number of lead candidates are under evaluation in the NICHD Contraceptive Clinical Trials Network (CCTN) (1–3).

Adding It Up: Investing in Sexual and Reproductive Health 2019

“…4 Some of the new options under development include hormonal and nonhormonal male contraceptive methods, which would give men more options to control their own fertility and increase protection against unintended pregnancy if both partners are using a method. 56 Currently, the majority of women wanting to avoid a pregnancy are using female-controlled modern contraceptive methods, and only 17% are using a method that requires their partner's involvement (male condoms, male sterilization or fertility awareness-based methods). 45…”

Prospek Kontrasepsi Pria dalam Pengendalian Pertumbuhan Penduduk melalui Pendekatan Molekular

“…Protein antibodi atau molekul kecil lainnya digunakan sebagai agen kontraseptif dalam penurunan produksi dan/atau fungsi sperma pada hewan coba maupun manusia. 10 Kontrasepsi Pria dengan Target Molekul pada Sel Gamet Beberapa sel memiliki permukaaan antigen yang unik, salah satunya adalah sel gamet (sperma) yang bersifat imunogenik, spesifik, dan dapat dikenali oleh antibodi. Sperma memiliki sifat yang unik yaitu bersifat autoantigen dan isoantigen sehingga mampu memicu produksi antibodi pada tubuh.…”

Intrauterine mepivacaine instillation for pain relief during intrauterine device insertion in nulliparous women: a double-blind, randomized, controlled trial

“…In 2016, 1 324 518 prescriptions of SARCs were collected, compared to 113 986 prescriptions of LARCs (106). IUDs are the most cost-effective methods (107) and are also the most eco-friendly in terms of environmental impact (108). These arguments, together with the fact that several studies have shown that LARC promotion leads to a reduction of unintended pregnancies and repeat abortions (22,109) should appeal to Swedish stakeholders and contraceptive users.…”