Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance

Braga, Ana Lays; Cruz, Rafael Pereira da; Carneiro, Joara Nályda Pereira; Santos, Antônia Thassya Lucas dos; Sales, Débora Lima; Bezerra, Camila Fonseca; Fonseca, Victor Juno Alencar; Rocha, Janaína Esmeraldo; Freitas, Thiago Sampaio de; Campina, Fábia F.; Costa, Maria do Socorro; Amaral, Wanderlei do; Rebelo, Ricardo Andrade; Silva, Luiz Everson da; Ribeiro-Filho, Jaime; Coutinho, Henrique Douglas Melo; Rodrigues, Fabíola Fernandes Galvão; Morais-Braga, Maria Flaviana Bezerra

doi:10.1016/j.sajb.2021.07.017

Cited by 11 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Essential oils (EOs) present several volatile compounds with expressive antimicrobial activity [ 9 , 10 , 11 ]. With the considerable increase in antimicrobial resistance, these natural products have proven to be efficient weapons against multiresistant microorganisms [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

et al. 2022

Self Cite

View full text Add to dashboard Cite

One of the main global problems that affect human health is the development of bacterial resistance to different drugs. As a result, the growing number of multidrug-resistant pathogens has contributed to an increase in resistant infections and represents a public health problem. The present work seeks to investigate the chemical composition and antibacterial activity of the essential oil of Syzygium cumini leaves. To identify its chemical composition, gas chromatography coupled to mass spectrometry was used. The antibacterial activity test was performed with the standard strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 25853 and Staphylococcus aureus ATCC 25923 and multidrug-resistant clinical isolates E. coli 06, P. aeruginosa 24 and S. aureus 10. The minimum inhibitory concentration (MIC) was determined by serial microdilution as well as the verification of the modulating effect of the antibiotic effect. In this test, the oil was used in a subinhibitory concentration. The test reading was performed after 24 h of incubation at 37 °C. The results show that the major chemical constituent is α-pinene (53.21%). The oil showed moderate activity against E. coli ATCC 25922, with the MIC of 512 µg/mL; there was no activity against the other strains. The oil potentiated the effect of antibiotics demonstrating possible synergism when associated with gentamicin, erythromycin and norfloxacin against E. coli 06 and S. aureus 10.

show abstract

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, these fungi can develop a drug resistance [ 30 , 31 ]. Thus, natural products represent an alternative in the treatment of these infections, which can promote a reduction in the fungal virulence or even promote the action of drugs in combined therapies [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

LC-MS Analysis and Antifungal Activity of Turnera subulata Sm.

Andrade-Pinheiro

Souza

Ribeiro

et al. 2023

Plants

Self Cite

View full text Add to dashboard Cite

Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors.

show abstract

“…The use of health treatments and therapeutics in folk medicine is also reported ( Al-Abri et al, 2022 ). The bioactivity properties of plants have been attributed to their terpenoid, carotenoid and phenolic compounds ( Balahbib et al, 2021 , Braga et al, 2021 ; Perin et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, this plant has been used as an anti-inflammatory and anti-larvicide against Aedes aegypti ( Albuquerque et al, 2022 ). The main chemical constituents of Piper species essential oil comprise monoterpenes, sesquiterpenes, and oxygenated monoterpenes ( Do Nascimento et al, 2012 ) with biological activities ( Braga et al, 2021 , da Silva et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil

Henrique Fontoura,

Cristina Perin,

Paula Buratto

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance

Cited by 11 publications

References 29 publications

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

LC-MS Analysis and Antifungal Activity of Turnera subulata Sm.

Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil

Contact Info

Product

Resources

About