Piperine: Bioactivities and Structural Modifications

Huan, Qing; Lv, Min; Xu, Hui

doi:10.2174/1389557515666150101100509

Cited by 33 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antitumor activities Antioxidant activity Anti-inflammatory activity Memory improvement and anti-depressive Hepato-protective activity [20][21][22][23][24][25][26][27][28][29] PP Antitumor activity Antioxidant activity Anti-inflammatory activity Antimycobacterial activity Insecticidal activity [30] BSO Anti-cancer activity Anti-infective, anthelmintic, antimicrobial, anti-viral, anti-bacterial, antifungal, anti-parasitic and anti-spasmodic activity Cardiovascular, gastro-protective, hepato-protective, nephron-protective, and testicular-protective activity Pulmonary-protective activity, broncho-dilating and anti-asthmatic effects Antioxidant, immune-stimulant, immunomodulatory activity Hypoglycemic and anti-hypertensive activity Anti-inflammatory, antihistaminic and analgesic, antipyretic, and anti-ulcerative activity Neuro-pharmacological, anticonvulsant and antidepressant activity [31][32][33][34] APO Antioxidant activity [35] AVO Antioxidant activity Promotes the accumulation of HDL cholesterol Anti-inflammatory activity Useful in cancer prevention [36] ZRO Anti-inflammatory activity Antibacterial activity Antiseptic properties Antioxidant activity Antidiarrheal activity [37][38][39] In the current study, four bioactive oils namely, black seed oil (BSO), avocado oil (AVO), apricot oil (APO) and Zanthoxylum rhetsa seed oil (ZRO) were investigated in the formulation of Bio-SNEDDS for CUR and PP delivery. In addition, these bioactive oils have several valuable nutritive and therapeutic effects on human health (Table 1).…”

Section: Curmentioning

confidence: 99%

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

et al. 2020

View full text Add to dashboard Cite

Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. Methods: The self-emulsifying properties of apricot, avocado, black seed and Zanthoxylum rhetsa seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl® and Neusilin® at 1:1 w/w ratio. Liquid and solid SNEDDS were characterized by droplet size analysis, equilibrium solubility, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed to evaluate the efficiency of CUR and PP release from solid Bio-SNEDDS. Results: The liquid SNEDDS comprised of black seed oil exhibited excellent self-emulsification performance, low droplet size along with transparent appearance. The inclusion of the cosolvent Transcutol P improved the solubilization capacity of both CUR and PP. The liquid SNEDDS were efficiently solidified using the two adsorbents and presented the drugs within amorphous state. In particular, SNEDDS comprised of black seed oil/Imwitor988/Transcutol P/Cremophor RH40 (20/20/10/50) and when solidified with Neusilin showed enhanced CUR and PP release (up to 60% and 77%, respectively). In addition, this formulation efficiently delivers the highly bioactive black seed oil to the patient. Conclusions: The optimized Bio-SNEDDS comprising black seed oil showed outstanding self-emulsification characteristics along with enhanced CUR/PP dissolution upon solidification.

show abstract

Section: Curmentioning

confidence: 99%

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

et al. 2020

View full text Add to dashboard Cite

show abstract

“… 10 , 11 However, most extracts of P. longum and other plants of the Piperaceae family often used in modernized versions of Ayurvedic formulation are in general analytically standardized, or analytically characterized, by their piperine contents only. 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain

Yadav

Chatterjee²,

Majeed

et al. 2016

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

AimTo compare stress resistance increasing and analgesic activities of piperlongumine and a methanolic Piper longum fruit extract (PLE).MethodsEfficacies of a single and repeated daily oral doses (1–256 mg/kg/day) of PLE, piperlongumine, and 50 mg/kg/day doxycycline against foot shock stress triggered alteration in body weights and core temperatures, and of their 11 daily doses on antidepressants like activity in tail suspension test and on pentobarbital induced sedation in male mice were compared. In another experiment, analgesic activities of single and repeated daily 5 mg/kg oral doses of piperlongumine and PLE in mice hot plate test and in acetic acid induced writing tests were compared with those of aspirin and doxycycline.ResultsAfter their single oral doses no effects of piperlongumine or PLE or doxycycline were observed in the footshock stress induced hyperthermia test or in hot plate test. However, significant effects of piperlongumine and PLE in both the tests were observed after their 5 or more daily doses. Both of them also dose dependently suppressed daily handling and repetitive testing triggered alterations in body weights and core temperatures. Their doxycycline like antidepressant activity in tail suspension test and aspirin like analgesic effects in acetic acid writhing test were observed after their 11 daily 5 mg/kg oral dose.ConclusionPiperlongumine is another bioactive secondary metabolite of P. longum and other plants of piper species with stress response suppressing, analgesic, and anti-inflammatory activities. Its bactericidal activities can also contribute to its therapeutically interesting bio-activity profile.

show abstract

“…Piperine is a major alkaloid found in Piper plants [31,32] which has an inhibitory effect on aflatoxin B 1 biosynthesis and the growth of A. flavus mycelia at a concentration of 0.7% ( w / v ) [25]. Recently, Park et al [25] showed that piperonal, one of the major compounds in P. nigrum essential oil, inhibited aflatoxin B 1 production and it diverted the aflatoxin B 1 biosynthetic route to aflatoxin G2 production.…”

Section: Resultsmentioning

confidence: 99%

Antifungal and Antiaflatoxigenic Methylenedioxy-Containing Compounds and Piperine-Like Synthetic Compounds

Moon

Choi

Park

et al. 2016

Toxins

View full text Add to dashboard Cite

Twelve methylenedioxy-containing compounds including piperine and 10 piperine-like synthetic compounds were assessed to determine their antifungal and antiaflatoxigenic activities against Aspergillus flavus ATCC 22546 in terms of their structure–activity relationships. Piperonal and 1,3-benzodioxole had inhibitory effects against A. flavus mycelial growth and aflatoxin B1 production up to a concentration of 1000 μg/mL. Ten piperine-like synthetic compounds were synthesized that differed in terms of the carbon length in the hydrocarbon backbone and the presence of the methylenedioxy moiety. In particular, 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one had potent antifungal and antiaflatoxigenic effects against A. flavus up to a concentration of 1 μg/mL. This synthetic compound was remarkable because the positive control thiabendazole had no inhibitory effect at this concentration. Reverse transcription-PCR analysis showed that five genes involved in aflatoxin biosynthesis pathways were down-regulated in A. flavus, i.e., aflD, aflK, aflQ, aflR, and aflS; therefore, the synthetic compound inhibited aflatoxin production by down-regulating these genes.

show abstract

Piperine: Bioactivities and Structural Modifications

Cited by 33 publications

References 0 publications

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain

Antifungal and Antiaflatoxigenic Methylenedioxy-Containing Compounds and Piperine-Like Synthetic Compounds

Contact Info

Product

Resources

About