Piperine blocks voltage gated K+ current and inhibits proliferation in androgen sensitive and insensitive human prostate cancer cell lines

George, Kiran; Thomas, Nisha Susan; Malathi, R.

doi:10.1016/j.abb.2019.04.007

Cited by 22 publications

(11 citation statements)

References 48 publications

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“…[ 122 ] Specific inhibitors of Kv1.3, such as margatoxin (MgTX), blocked lung adenocarcinoma cell proliferation and decreased tumor volume in vivo. [ 123,124 ] Other specific inhibitors of Kv1.3 include piperine in prostate cancer cells, [ 125 ] 5‐(4‐phenoxybutoxy)psoralen (PAP‐1) in leukaemia, [ 126,127 ] and rituximab in T‐cells. [ 128 ] Non‐specific Kv blockers such as 4‐aminopyridine (4‐AP) and tetraethylammonium (TEA) have proved effective against glioma [ 129 ] and breast cancer [ 130 ] cells, respectively.…”

Section: Strategies To Hijack Endogenous Bioelectricity Of Cancer Cellsmentioning

confidence: 99%

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Robinson

Jain

Sherman

et al. 2021

Advanced Therapeutics

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Bioelectronic medicine is a treatment modality that uses electricity to treat disease by altering the body's electrical communication systems. All cells are electrically active, in that they possess bioelectric circuitry generating a resting membrane potential and endogenous electric fields that influence cell functions and communication. There is now an accepted paradigm that cancer is characterized by malfunctions in cells' bioelectrical circuitry. This yields opportunities for bioelectronic medicine as novel treatments for cancer by manipulating its bioelectrical properties. To highlight the possibilities a bioelectrical approach can offer cancer therapy, the relevance of bioelectrical activity in cancer is reviewed and also how such activity can be hijacked in novel treatments. This includes sensing or measuring the electrical activity of cells for diagnostic and prognostic applications, controlling or altering bioelectricity including both ionic and faradaic current processes, and eliciting morphological changes using electric fields. Importantly, key links between cellular ionic and faradaic processes that contribute to cancer phenotypes are presented, which if considered and understood as a whole, can bring broad-reaching improvements to cancer therapy.

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Section: Strategies To Hijack Endogenous Bioelectricity Of Cancer Cellsmentioning

confidence: 99%

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Robinson

Jain

Sherman

et al. 2021

Advanced Therapeutics

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“…Piperine shows many bioactivities like anxiolytic, antiaggregant, antioxidant, antispasmodic, antidepressant, antiasthmatic, and anticancer ( Shityakov et al., 2019 ). Piperine induces cell death in a dose-dependent manner in PCa cells, PC-3 and LNCaP, through induction of apoptosis via obstructing voltage-gated K+ current (IK) and cell cycle arrest ( Ba and Malhotra, 2018 ; George et al., 2019 ). It has also been reported that Piperine inhibited the migration and induced apoptotic cell death in DU145 cells through the downregulation of phospho-Akt/phospho-mTOR/MMP-9 ( Zeng and Yang, 2018 ).…”

Section: Importance Of Natural Products In Prostate Cancer Therapymentioning

confidence: 99%

Prostate cancer: Therapeutic prospect with herbal medicine

Ghosh

Hazra

Pal

et al. 2021

Current Research in Pharmacology and Drug Discovery

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Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. A geographic variation on the burden of the disease suggested that the environment, genetic makeup, lifestyle, and food habits modulate one's susceptibility to the disease. Although it has been generally thought to be an older age disease, and awareness and timely execution of screening programs have managed to contain the disease in the older population over the last decades, the incidence is still increasing in the population younger than 50. Existing treatment is efficient for PCa that is localized and responsive to androgen. However, the androgen resistant and metastatic PCa are challenging to treat. Conventional radiation and chemotherapies are associated with severe side effects in addition to being exorbitantly expensive. Many isolated phytochemicals and extracts of plants used in traditional medicine are known for their safety and diverse healing properties, including many with varying levels of anti-PCa activities. Many of the phytochemicals discussed here, as shown by many laboratories, inhibit tumor cell growth and proliferation by interfering with the components in the pathways responsible for the enhanced proliferation, metabolism, angiogenesis, invasion, and metastasis in the prostate cells while upregulating the mechanisms of cell death and cell cycle arrest. Notably, many of these agents simultaneously target multiple cellular pathways. We analyzed the available literature and provided an update on this issue in this review article.

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“…The level of PSA (Prostate-Specific Antigen) in LNCaP cells was markedly reduced [65]. Treatment of LNCaP and PC-3 cells with piperine caused a concentration-dependent cell cycle arrest at the G1 phase and apoptosis [66,67]. Studies have shown that piperine inhibits the migration and proliferation of prostate cancer cells by activating signaling pathways, such as mTOR (mechanistic target of rapamycin) and MMP-9 (matrix metallopeptidase-9) [68].…”

Section: Piperine and Prostate Cancermentioning

confidence: 99%

Piperine: A Savor Inducer and a Cancer Reducer

Djaldetti¹

2021

OBM HG

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Spices have been used for many decades, and although new and improved culinary spices have been developed, black pepper (<em>Piper nigrum</em>) continues to retain its distinguished title as the <em>“King of spices”</em> due to its particular pungent taste. An alkaloid called piperine is the main component in black pepper that, besides generating the well-known taste, imparts well-documented immunomodulatory, anti-inflammatory, antimicrobial, antioxidant, and even anti-cancer properties; these properties have led to rigorous research on black pepper. Studies conducted on cancer cell lines and in animal models with tumors revealed that piperine might influence tumor development and metastasis via various pathways, some of which are quite common for most types of malignant processes, while others are associated with a specific type of cancer. In this review, we summarized the effect of piperine on various types of cancer and the mechanism by which it acts as a carcinopreventive agent.

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Piperine blocks voltage gated K+ current and inhibits proliferation in androgen sensitive and insensitive human prostate cancer cell lines

Cited by 22 publications

References 48 publications

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Prostate cancer: Therapeutic prospect with herbal medicine

Piperine: A Savor Inducer and a Cancer Reducer

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