Piroxicam Solubility in Binary and Ternary Solvents of Polyethylene Glycols 200 or 400 with Ethanol and Water at 298.2 K: Experimental Data Report and Modeling

Abstract

The solubilities of piroxicam in binary and ternary mixtures of polyethylene glycols 200 or 400 with ethanol and water (138 data points) at 298.2 K were determined and mathematically represented by cosolvency models. The solubilities were measured using the shake flask method and the models are used to fit the solubility data of piroxicam in the solvent mixtures. The overall mean relative deviations (OMRDs %) for fitting the solubility data of piroxicam in binary and ternary mixtures using the Williams-Amidon and Jouyban-Acree models are 30.7 and 26.8 %, respectively, and the OMRD % values for predicting the solubilities of piroxicam by the trained versions of the Jouyban-Acree model is 57.3 %.

Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

“…Log x Yal values of ECT obtained by the "Yalkowsky-Roseman" model in various "PEG-400 + water" combinations (m) at "T = 298.2 to 318.2 K". The "logarithmic solubility of Yalkowsky-Roseman model (log x Yal )" of ECT was calculated by applying Equation (13) and the correlation between x e and x Yal values of ECT was performed in terms of RMSD values.…”

“…"Polyethylene glycol-400 (PEG-400)" has been reported as an efficient cosolvent in solubilization of drugs in aqueous media and it is miscible with water in all proportions [9][10][11]. The potential of PEG-400 has been studied extensively in solubility enhancement of various drugs [9][10][11][12][13][14][15][16][17][18]. Several formulation approaches including "3D printed controlled release tablets [4], film coated tablets [19], rapidly disintegrating vaginal tablets [20], immediate release tablets [21], vaginal gels [22], liposomal gels [23], microparticulate drug delivery system [24], nanosuspensions [25,26] and polymeric nanoparticles [5,27,28]" were reported to improve antiviral therapy and pharmacokinetic profile of ECT.…”

Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

“…This behavior is quite common, and it is manifested by the appearance of a maximum on the molar fraction solubility plotted as a function of binary solvent composition. Some recent examples reported in the literature of such behavior include aqueous binary mixtures of nicotinamide in dimethyl sulfoxide (DMSO) [11], theophylline in 1-butanol [12], phenacetin in 1,4-dioxane [13,14], sulfanilamide in 1,4-dioxane [15], paracetamol in ethanol and propylene glycol [16], 4-(hydroxymethyl)benzoic acid in ethanol [17], and piroxicam in ethanol [18].…”