Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.

Yada, Toshihiko; Sakurada, Masaya; Ihida, Kaori; Nakata, Masao; Murata, Fusayoshi; Arimura, Akira; Kikuchi, Masatoshi

doi:10.1016/s0021-9258(17)42256-3

Cited by 228 publications

(19 citation statements)

References 33 publications

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“…In turn, in the pancreas, PACAP is one of the most potent secretory agents and stimulates both exocrine and endocrine secretion. It was confirmed that PACAP induces amylase [86], secretin, amylase and lipase [87,88] and bicarbonate secretion [89] and increases local blood flow [90]. The influence of PACAP on pancreatic endocrine secretion has been studied in detail in many in vitro and in vivo animal models and humans.…”

Section: Physiological Role Of Pacap In the Gi Tractmentioning

confidence: 91%

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Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Physiological and Pathological Processes within the Gastrointestinal Tract: A Review

Karpiesiuk

Palus

2021

IJMS

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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide widely distributed in the central nervous system (CNS) and many peripheral organs, such as the digestive tract, endocrine, reproductive and respiratory systems, where it plays different regulatory functions and exerts a cytoprotective effect. The multifarious physiological effects of PACAP are mediated through binding to different G protein-coupled receptors, including PAC1 (PAC1-R), VPAC1 (VPAC1-R) and VPAC2 (VPAC2-R) receptors. In the gastrointestinal (GI) tract, PACAP plays an important regulatory function. PACAP stimulates the secretion of digestive juices and hormone release, regulates smooth muscle contraction, local blood flow, cell migration and proliferation. Additionally, there are many reports confirming the involvement of PACAP in pathological processes within the GI tract, including inflammatory states, neuronal injury, diabetes, intoxication and neoplastic processes. The purpose of this review is to summarize the distribution and pleiotropic action of PACAP in the control of GI tract function and its cytoprotective effect in the course of GI tract disorders.

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Section: Physiological Role Of Pacap In the Gi Tractmentioning

confidence: 91%

“…The influence of PACAP on pancreatic endocrine secretion has been studied in detail in many in vitro and in vivo animal models and humans. PACAP participates in glycemic control by glucose-dependent stimulation of glucagon and insulin secretion [90,91].…”

Section: Physiological Role Of Pacap In the Gi Tractmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Physiological and Pathological Processes within the Gastrointestinal Tract: A Review

Karpiesiuk

Palus

2021

IJMS

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“…In islets, G-proteins transduce signals responsible for the modulation of insulin and glucagon secretion (Skoglund and Rosselin 1993). They organize, through specific cell receptors, transmembrane signals resulting from the binding of ligands such as ␤-catecholamine (Porte 1967), glucose-dependent insulinotropic peptide (GIP) (Maletti et al 1984), vasoactive intestinal peptide (VIP) (Anteunis et al 1989), pituitary adenylate cyclase activating polypeptide (PACAP) (Klinteberg et al 1996;Yada et al 1994;Boissard et al 1996;Leech and Habener 1996), gut glucagon (Bataille et al 1977), truncated glucagon-like peptide (GLP-1) (Fridolf and Ahren 1993;Leech and Habener 1996), and calcitonin gene-related peptide (CGRP) (Barakat et al 1994). G-proteins are abundant in B-cell lines (Walseth et al 1989;Cormont et al 1991;Marie et al 1996) and in rat islet pancreas, predominantly in B-cells (Skoglund et al 1995;Astesano et al 1996Astesano et al , 1997.…”

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confidence: 99%

Cellular and Subcellular Expression of Golf/Gs and Gq/G11 α-Subunits in Rat Pancreatic Endocrine Cells

Astesano

Régnauld

Ferrand

et al. 1999

J Histochem Cytochem.

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SUMMARYWe studied the cellular and subcellular localization of G ␣-subunits in pancreas by immunocytochemistry. Golf ␣ and G11 ␣ were specifically localized in islet insulin B-cells and glucagon A-cells, respectively. Gs ␣ and Gq ␣ labeling was more abundant in B-cells. The presence of Golf ␣ in B-cells was confirmed by in situ hybridization. In B-cells, Golf ␣ and Gs ␣ were found in the Golgi apparatus, plasma membrane (PM) and, remarkably, in mature and immature insulin secretory granules, mainly at the periphery of the insulin grains. Gq ␣ was detected on the rough endoplasmic reticulum (RER) near the Golgi apparatus. In A-cells, the G ␣-subunits were mostly within the glucagon granules: G11 ␣ gave the strongest signal, Gs ␣ less strong, Gq was scarce, and Golf was practically absent. Gq ␣ and Gs ␣ immunoreactivity was detected in acinar cells, although it was much weaker than that in islet cells. The cell-dependent distribution of the G ␣-subunits indicates that the stimulatory pathways for pancreatic function differ in acinar and in islet B-and A-cells. Furthermore, the G-protein subunits in islet cell secretory granules might be functional and participate in granule trafficking and hormone secretion.

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“…ADCYAP1 is known to play roles in glucose and energy homeostasis [17], and in the regulation of lipid metabolism [18]. In an ADCYAP1 knockout mouse model, white adipose tissue (e.g., epididymal, retroperitoneal, and abdominal subcutaneous adipose tissues) was significantly reduced in size and mass.…”

Section: Discussionmentioning

confidence: 99%

The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle

Liu

Wang

et al. 2021

Animals

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FATP1 plays an important role in the regulation of fatty acid metabolism and lipid accumulation. In this study, we investigated the patterns of FATP1 expression in various tissues obtained from calf and adult Qinchuan cattle, and in differentiating adipocytes. Next, we investigated the effect of FATP1 expression on preadipocyte differentiation in Qinchuan cattle using overexpression and interference assays. We also identified the differentially expressed genes (DEGs) and pathways associated with FATP1 overexpression/interference. Our results reveal that FATP1 was broadly expressed in heart, kidney, muscle, small intestine, large intestine, and perirenal fat tissues. While FATP1 overexpression promoted preadipocyte differentiation, fat deposition, and the expression of several genes involved in fat metabolism, FATP1 interference had the opposite effects on adipocyte differentiation. Following FATP1 overexpression and FATP1 interference in adipocytes, RNA-seq analysis was performed to identify DEGs related to fat metabolism. The DEGs identified include SLPI, STC1, SEMA6A, TNFRSF19, SLN, PTGS2, ADCYP1, FADS2, and SCD. Pathway analysis revealed that the DEGs were enriched in the PPAR signaling pathway, AMPK signal pathway, and Insulin signaling pathway. Our results provide an in-depth understanding of the function and regulation mechanism of FAPT1 in fat metabolism.

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Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.

Cited by 228 publications

References 33 publications

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Physiological and Pathological Processes within the Gastrointestinal Tract: A Review

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Physiological and Pathological Processes within the Gastrointestinal Tract: A Review

Cellular and Subcellular Expression of Golf/Gs and Gq/G11 α-Subunits in Rat Pancreatic Endocrine Cells

The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle

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