Pituitary and testicular function in the restricted (H<sup>re</sup>) rat

Heindel, Jerrold J.; Berkowitz, Albert S.; Grotjan, H. Edward; Herbert, Damon C.; Klemckes, H. G.; Bartke, Andrzej

doi:10.1111/j.1365-2605.1988.tb01004.x

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Thus, we have found a decrease of the gonadotroph population in undernourished monkeys in agreement with the alter- ations described in such population from undernourished rats (18,19).…”

Section: Discussionsupporting

confidence: 79%

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Cónsole

Jurado

Oyhenart

et al. 2001

Braz J Med Biol Res

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Undernutrition elicited by a low-protein diet determines a marked reduction of hypophyseal activity and affects the function of the respective target organs. The objective of the present investigation was to study the ultrastructural and quantitative immunohistochemical changes of the different pituitary cell populations in undernourished monkeys that had been previously shown to have significant changes in craniofacial growth. Twenty Saimiri sciureus boliviensis monkeys of both sexes were used. The animals were born in captivity and were separated into two groups at one year of age, i.e., control and undernourished animals. The monkeys were fed ad libitum a 20% (control group) and a 10% (experimental group) protein diet for two years. Pituitaries were processed for light and electron microscopy. The former was immunolabeled with anti-GH, -PRL, -LH, -FSH, -ACTH, and -TSH sera. Volume density and cell density were measured using an image analyzer. Quantitative immunohistochemistry revealed a decrease in these parameters with regard to somatotrophs, lactotrophs, gonadotrophs and thyrotrophs from undernourished animals compared to control ones. In these populations, the ultrastructural study showed changes suggesting compensatory hyperfunction. On the contrary, no significant changes were found in the morphometric parameters or the ultrastructure of the corticotroph population. We conclude that in undernourished monkeys the somatotroph, lactotroph, gonadotroph, and thyrotroph cell populations showed quantitative immunohistochemical changes that can be correlated with ultrastructural findings.

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“…Thus, we have found a decrease of the gonadotroph population in undernourished monkeys in agreement with the alter- ations described in such population from undernourished rats (18,19).…”

Section: Discussionsupporting

confidence: 79%

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Cónsole

Jurado

Oyhenart

et al. 2001

Braz J Med Biol Res

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“…Morphometric and ultrastructural analysis of hypophyseal cells from adult monkeys fed a protein‐restricted diet containing 10% protein have shown a decline in the number of somatotrophic, lactotrophic, gonadotrophic and tireotrophic cells. The volumetric density and frequency distribution of these cells were also significantly lower (Herbert, 1980a,b; Heindel et al ., 1988; Cónsole et al ., 2001).…”

Section: Discussionmentioning

confidence: 99%

Maternal malnutrition during lactation reduces skull growth in weaned rat pups: Experimental and morphometric investigation

Fernandes

Abreu

Silva

et al. 2008

Anatomical Science International

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The purpose of the present study was to evaluate the effects of maternal protein and energy restriction during lactation on the bodyweight and skull dimensions of pups at weaning. At parturition, Wistar rat dams were randomly assigned to the following groups: (i) control group (C), free access to a standard laboratory diet containing 23% protein; (ii) protein-energy-restricted group (PER), free access to an isoenergetic, protein-restricted diet containing 8% protein; and (iii) energy-restricted group (ER), restricted amounts of a standard laboratory diet. The dimensions of excised pup skulls were measured directly using pre-established anatomical points. Morphometrical analysis of the skulls showed that most of the measurements in the ER and PER groups were significantly lower than in the control group, with the greatest reductions occurring in the PER group. These results show that protein and energy restriction during lactation have an important influence on pup skull development.

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“…The volumetric density and frequency distribution of these cells were also significantly lower. (Heindel et al, 1988;Rosenbaum & Leibel, 1998;Léonhardt et al, 2003;Faria et al).…”

Section: Discussionmentioning

confidence: 99%

Effects of Protein and Energy Restricted Diet During Lactation Leads to Persistent Morphological Changes on Tibia Growth in the Weaned Pups

et al. 2007

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FERNANDES, R. M. P.; ABREU, A. V.; SCHANAIDER, A.; SOARES JR., E. R.; PEÇANHA, G. C. A.; BABINSKI, M. A. & RAMOS, C. F. Effect of protein and energy restricted diet during lactation leads to persistent morphological changes on tibia growth in the weaned pups. Int. J. Morphol., 25(3):565-571, 2007. SUMMARY:The purpose of this study was to evaluate the effects of maternal protein and energy restriction during lactation on the body weight and tibiae dimensions of pups at aging. At parturition, Wistar rat dams were randomly assigned to the following groups: 1) control group (C) -free access to a standard laboratory diet containing 23% protein, 2) protein-energy restricted group (PR) -free access to an isoenergetic, protein-restricted diet containing 8% protein, and 3) energy-restricted group (ER) -fed restricted amounts of a standard laboratory diet. At weaning, all pups were separated of dams and received free access to a standard laboratory diet containing 23% protein until 180 days when the rats were anesthetized and sacrificed. The dimensions of excised pup tibia were measured directly using pre-established anatomical points. Morphometrical analysis of the tibia showed that most of the measurements in the ER and PR groups were significantly lower than in the control group, with the greatest reductions occurring in the PR group. These results show that protein and energy restriction during lactation have an important influence on pup tibia development. FERNANDES, R. M. P.; ABREU, A. V.; SCHANAIDER, A.; SOARES JR., E. R.; PEÇANHA, G. C. A.; BABINSKI, M. A. & RAMOS, C. F. Efectos de las restricciones de proteínas y de energía durante la lactancia provocan cambios morfológicos persistentes en el crecimiento de la tibia de crías destetadas. Int. J. Morphol., 25(3):565-571, 2007.RESUMEN: Los objetivos de este estudio fueron evaluar los efectos de la restricción materna de proteínas y de energía durante la lactancia y sus efectos en el peso corporal y las dimensiones de las tibias de crías en ratas. En el parto, las crías de ratas Wistar fueron agrupadas aleatoriamente en los grupos siguientes: 1) grupo control (C) -con acceso libre a una dieta estándar del laboratorio, que contenía 23% de proteínas; 2) grupo con restricción de proteínas y energía (PR) -acceso libre a una dieta isoenergética, con restricción de proteínas, conteniendo un 8% de éstas y 3) grupo con restricción de energía, alimentado con restricción en la cantidad de alimento de la dieta estándar del laboratorio (ER). Al destete, todas las crías fueron separadas y recibieron la dieta estándar del laboratorio, conteniendo 23% de proteínas, hasta los 180 días, cuando fueron anestesiadas y sacrificadas. El análisis morfométrico de la tibia demostró que la mayoría de las mediciones en los grupos ER y PR, fueron significativamente menores que las del grupo control, con mayores reducciones en el grupo PR. Estos resultados muestran que las restricciones de energía y proteínas durante la lactancia tienen una influencia importante en el desarrollo de la tibia de la...

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Pituitary and testicular function in the restricted (H^re) rat

Cited by 6 publications

References 29 publications

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Maternal malnutrition during lactation reduces skull growth in weaned rat pups: Experimental and morphometric investigation

Effects of Protein and Energy Restricted Diet During Lactation Leads to Persistent Morphological Changes on Tibia Growth in the Weaned Pups

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Pituitary and testicular function in the restricted (Hre) rat

Cited by 6 publications

References 29 publications

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Maternal malnutrition during lactation reduces skull growth in weaned rat pups: Experimental and morphometric investigation

Effects of Protein and Energy Restricted Diet During Lactation Leads to Persistent Morphological Changes on Tibia Growth in the Weaned Pups

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Pituitary and testicular function in the restricted (H^re) rat