Pituitary-Thyroid Axis, Thyroid Volume and Leptin in Healthy Adults

Jm, Gómez Sáez; Fj, Maravall; Gómez, Núria; Gumà, Anna; Casamitjana, Roser; Soler, Juan

doi:10.1055/s-2002-20529

Cited by 28 publications

(27 citation statements)

References 18 publications

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“…Oberhofer et al reported the mean thyroid volume as 13.35 ml (man 14.94 m, women 12.09 ml in 500 healthy adults at 1989in Austria (15). Gomez et al reported the thyroid volume as 9.8±4.6 ml form an and 6.5±2 ml for women (16). In our study these volumes were 15.87±7.18 ml and 10.94±4.53 ml respectively (mean 13±6 ml) (p=0.000).…”

Section: Discussionsupporting

confidence: 49%

Determination of Thyroid Volume and Its Relation with Isthmus Thickness

Şeker

Taş²

2010

ELECTRON J GEN MED

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Section: Discussionsupporting

confidence: 49%

Determination of Thyroid Volume and Its Relation with Isthmus Thickness

Şeker

Taş²

2010

ELECTRON J GEN MED

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“…25 However, it must be emphasized that this putative relation between TSH and leptin is not supported by all studies. 26,27 We only found the relation between TSH and BMI in nonsmokers. A similar but weaker trend was seen in the smokers, but the results were not statistically significant.…”

mentioning

confidence: 83%

Serum TSH is positively associated with BMI

2005

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Objective: To investigate whether there is an association between serum thyroid-stimulating hormone (TSH) within the normal range and body mass index (BMI). Design and subjects: The study was performed in 6164 subjects (2813 males) who attended the fifth Tromsø study in 2001, and in 1867 subjects (873 males) that attended both the fourth Tromsø study in 1994/1995 as well as the fifth Tromsø study. Measurements: Height, weight, and serum TSH were measured in all subjects, and smoking status was recorded. Results: Smokers and nonsmokers were analyzed separately. In the fifth Tromsø study, serum TSH was positively and significantly associated with BMI in the nonsmokers. Within the normal TSH range (defined as the 2.5-97.5 percentile), nonsmoking males in the highest TSH quartile had a mean BMI 0.4 kg/m 2 higher compared to those in the lower quartile, whereas the difference for nonsmoking women was 1.4 kg/m 2 . Similarly, in nonsmokers in the longitudinal study, there was a significant and positive association between delta serum TSH (serum TSH in 2001 minus serum TSH in 1994) and delta BMI in those with serum TSH within the normal range both in 1994 and 2001. In these subjects, the quartile with the highest delta serum TSH had a mean increase in BMI from 1994 to 2001 that was 0.3 kg/m 2 higher compared to those in the quartile with the lowest delta serum TSH. For the smokers, relations between serum TSH and BMI were not statistically significant. Conclusion: In nonsmokers there is a positive association between serum TSH within the normal range and BMI.

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“…Thyroid volumetry was performed according to the method of Brunn et al (11) and as previously described (12) . To assess thyroid enlargement, two different reference values for Tvol were used: an old reference value where thyroid enlargement was defined as a Tvol exceeding 18 ml (13) and a revised reference value where we defined thyroid enlargement as a Tvol exceeding 12?5 ml (14,15) . The revised reference value is based on a healthy, non-iodine deficient Spanish population and mean Tvol (6?5 ml) 1 3SD (6?0 ml) in this population was used to define the cut-off of 12?5 ml (14,15) .…”

Section: Methodsmentioning

confidence: 99%

Iodine-induced goitre and high prevalence of anaemia among Saharawi refugee women

Henjum

Barikmo

Strand

et al. 2011

Public Health Nutr.

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Objective: The main objective was to assess iodine status (thyroid volume (Tvol) and urinary iodine concentration (UIC)) and their determinants in Saharawi refugee women. Design: A cross-sectional survey was performed during January-February 2007. Tvol was measured by ultrasound and iodine concentration was analysed in spot urine samples and in household drinking water. Anthropometry and Hb concentration were measured and background variables were collected using pre-coded questionnaires. Setting: The survey was undertaken in four long-term refugee camps in the Algerian desert. Subjects: Non-pregnant women (n 394), 15-45 years old, randomly selected. Results: Median (25th percentile-75th percentile (P 25 -P 75 )) UIC was 466 (294-725) mg/l. Seventy-four per cent had UIC above 300 mg/l and 46 % above 500 mg/l. Median (P 25 -P 75 ) Tvol was 9?4 (7?4-12?0) ml and the goitre prevalence was 22 %. UIC was positively associated with iodine in drinking water and negatively associated with breast-feeding, and these two variables explained 28 % of the variation in UIC. The mean (SD) Hb level was 11?8 (2?4) g/dl. In total 46 % were anaemic with 14 %, 25 % and 7 %, classified with respectively mild, moderate and severe anaemia. Conclusions: The Saharawi women had high UIC, high levels of iodine in drinking water and increased Tvol and probably suffered from iodine-induced goitre. The high prevalence of anaemia is considered to be a severe public health concern. To what extent the excessive iodine intake and the anaemia have affected thyroid function is unknown and should be addressed in future studies. KeywordsExcess urinary iodine Iodine-rich drinking water Saharawi refuge women Iron deficiencyWomen's micronutrient status is of particular importance since it affects not only their own health, but also the health of their children (1) . Deficiencies of iodine and Fe remain major public health problems, affecting .30 % of the global population (2,3) . Insufficient iodine intake as well as excess iodine intake may cause thyroid diseases (4) . Fe deficiency is the most common and widespread micronutrient deficiency worldwide (3) and may have multiple adverse effects on thyroid metabolism (5) . Refugees from Western Sahara have been settled in the Algerian desert since 1975 and they are totally dependent on food aid in the harsh, resource-poor desert environment. The refugee population is experiencing a number of challenges related to their food, nutrition and health situation (6) . Endemic goitre has been reported among Saharawi schoolchildren and this is probably caused by iodine excess (7)(8)(9)(10) , but further studies are required to understand the aetiology. The main objective of the present paper is to assess iodine status (thyroid volume (Tvol) and urinary iodine concentration (UIC)) and their determinants in Saharawi refugee women of childbearing age. The secondary objective is to assess their prevalence of anaemia. Women (15-45 years old) were the target group. We calculated the sample size based on an esti...

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Pituitary-Thyroid Axis, Thyroid Volume and Leptin in Healthy Adults

Cited by 28 publications

References 18 publications

Determination of Thyroid Volume and Its Relation with Isthmus Thickness

Determination of Thyroid Volume and Its Relation with Isthmus Thickness

Serum TSH is positively associated with BMI

Iodine-induced goitre and high prevalence of anaemia among Saharawi refugee women

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