1999
DOI: 10.1038/sj.onc.1203127
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PKR; a sentinel kinase for cellular stress

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Cited by 749 publications
(638 citation statements)
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References 79 publications
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“…We therefore focused our attention on the signaling events that link LPS stimuli to phosphorylation of STAT1. Since PKR was reported to be an important signal transducer in the proinflammatory response to diverse stimuli (Gusella et al, 1995;Williams, 1999), we hypothesized that PKR could be an upstream component of the LPSinduced STAT inflammatory signaling pathway in brain immune cells.…”
Section: Discussionmentioning
confidence: 99%
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“…We therefore focused our attention on the signaling events that link LPS stimuli to phosphorylation of STAT1. Since PKR was reported to be an important signal transducer in the proinflammatory response to diverse stimuli (Gusella et al, 1995;Williams, 1999), we hypothesized that PKR could be an upstream component of the LPSinduced STAT inflammatory signaling pathway in brain immune cells.…”
Section: Discussionmentioning
confidence: 99%
“…Since PKR has been reported to function as an important signal transducer in the proinflammatory re-sponse to diverse stimuli (Gusella et al, 1995;Williams, 1999), we hypothesized that PKR could be an upstream component of the LPS-induced STAT inflammatory signaling pathway in brain immune cells. We therefore examined whether LPS could activate PKR phosphorylation in rat primary microglia and astrocyte.…”
Section: Lps Rapidly Induces Phosphorylation Of Pkr Followed By Phosmentioning
confidence: 99%
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“…14,15 Viral dsRNAs also activate 5 0 -oligoadenylate synthetases (OAS), which in turn activate an enzyme that degrades 18S and 28S ribosomes, RNase L. 16 Activated PKR phosphorylates and so inactivates eucaryotic translation initiation factor 2 (eIF2a). 17,18 Both activation of RNase L and inactivation of eIF2a inhibit virus replication by decreasing production of viral (and cellular) proteins.…”
Section: Discussionmentioning
confidence: 99%
“…4 One of the major cellular antiviral proteins is the serine-threonine kinase, dsRNA-activated protein kinase (PKR). 5 The protein consists of two functionally distinct domains: an N-terminal regulatory domain (ND) and a Cterminal catalytic kinase domain (KD). The regulatory domain contains two dsRNA-binding motifs, followed by a spacer.…”
mentioning
confidence: 99%