PL-002 Synthesis and antimicrobial activity of the novel siderophore sulfactam BAL30072

Targeting iron assimilation to develop new antibacterials

“…7), was recently disclosed by Basilea Pharmaceutica. 24 is a hybrid compound containing an hydroxypyridinone bait tethered to a metallo-β-lactamase resistant sulfolactam core [78–82]. A thorough in vitro evaluation of 24 against Gram negative pathogens revealed MIC 90 values in the single digit micromolar range for Actinobacter spp., E. coli , and P. aeruginosa , among many others [81].…”