Place of probiotics in the prevention and treatment of antibiotic-associated diarrhea

Ey, Plotnikova; Yv, Zakharova

doi:10.17116/terarkh2015875127-131

Ter. arkh.

2015

DOI: 10.17116/terarkh2015875127-131

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Place of probiotics in the prevention and treatment of antibiotic-associated diarrhea

Plotnikova Ey

Zakharova Yv

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Cited by 4 publications

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A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea

Xue

Ma²

2020

Medicine

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This retrospective study aimed to explore the benefits and safety of probiotics (live combined Bacillus subtilis and Enterococcus faecium granules with multivitamines) for the treatment of children with antibiotic-associated diarrhea (AAD). A total of 72 children with AAD were analyzed in this study. Of these, 36 children received routine treatment plus probiotics, and were assigned to a treatment group. The other 36 children underwent routine treatment alone, and were assigned to a control group. Patients in both groups were treated for a total of 7 days. The efficacy and safety were evaluated by duration of diarrhea (days), number of dressings needed daily, abdominal pain intensity, stool consistency (as assessed by Bristol Stool Scale (BSS)), and any adverse events. After treatment, probiotics showed encouraging benefits in decreasing duration of diarrhea (days) (P < .01), number of dressings needed every day (P < .01), abdominal pain intensity (P < .01), and stool consistency (BSS (3–5), P < .01; BSS (6–7), P < .01). In addition, no adverse events were documented in this study. The findings of this study demonstrated that probiotics may provide promising benefit for children with AAD. Further studies are still needed to warrant theses findings.

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A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea

Xue

Ma²

2020

Medicine

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Approaches to the management of surgical patients with antibiotic-associated mild diarrhea

Egorov,

Lazareva,

Seliverstov

2023

Medicinskij sovet

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The paper highlights the issues of antibiotic-associated diarrhea (AAD) of mild severity in the treatment of surgical patients, its epidemiology, etiology, features of the clinical picture and approaches to therapy. The mild course of AAD includes diarrhea without signs of intoxication, leukocytosis and fever. Stool disorder in patients receiving antibiotics who are in a surgical hospital is an urgent medical problem, since this pathology prolongs the time of hospitalization, increases economic costs, reduces the quality of life and can even be the cause of the patient’s death. According to various authors, AAD develops in 40% of people receiving antibacterial therapy. A clinical example of the management of a patient with AAD and injury of the musculoskeletal system is considered in detail.The abolition of antibiotics is not a method of solving this problem, since the severity of the patient’s injuries requires further surgical treatment and prevention of purulent-septic complications. The key point in the treatment of mild AAD will be the appointment of probiotic drugs, which have an effect on the pathogenetic links of AAD. Probiotics are microorganisms that have been known since ancient times and are purposefully used for health improvement and longevity. One of the first probiotic drugs used before the era of the discovery of antibiotics can be considered Mechnikov curdled milk with unique medicinal properties. Prescribing probiotic therapy from the first day of taking antibiotics, without waiting for the results of laboratory examination, will significantly reduce the prevalence of clinical manifestations of both clostridial diarrhea and idiopathic AAD.

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Probiotics in the Modern World

Успенский

Фоминых

Низамитдиновна

et al. 2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim of review. The review highlights modern concepts of the role of microbiome in sustaining the human body, the place of probiotics in treatment and prevention of pathologies related to disorders in healthy microbiota.Key points. Microbiome is a unique panorganismal system normally maintaining self-equilibrium and possessing a vast and diverse functionality. Imbalance in normal microbiota can be assisted by probiotics, i.e. living microorganisms that sustain health of the host when being supplied in adequate amounts. Alike normal microflora, probiotic strains incorporate into general metabolism by mediating a spectrum of functions, e.g. maintaining colonisation resistance, nutrient metabolism, supplying the host with vital metabolites, regulation of local and adaptive immune responses, enhancing the intestinal barrier. Probiotics are applied in various diseases associated with general imbalances of the organism. Modern probiotic preparations are characterised by acid- and antibiotic-resistivity and safety, thus being suitable for treating gut microbiome-associated disorders in various age groups.Conclusion. Probiotic strains, as well as medications designed on their basis, are widely applied and show good promise. Further research into their properties will advance the prospects of probiotic treatment.

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Place of probiotics in the prevention and treatment of antibiotic-associated diarrhea

Cited by 4 publications

References 44 publications

A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea

A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea

Approaches to the management of surgical patients with antibiotic-associated mild diarrhea

Probiotics in the Modern World

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