Placebo Effect in Surgery for Meniere's Disease: A Double-blind, Placebo-Controlled Study on Endolymphatic Sac Shunt Surgery

Thomsen, J.; Bretlau, P; Tos, Mirko; Johnsen, N. J.

doi:10.1001/archotol.1981.00790410009002

Cited by 215 publications

(63 citation statements)

References 13 publications

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“…Sac surgery for MD has controversial efficacy based on the results of a placebo-control study [10]. A temporal bone study of cases after sac surgery showed that the sac shunt was incomplete in many cases and that hydrops persisted in all cases (15/15), even though the vertigo was well controlled [16].…”

Section: Discussionmentioning

confidence: 99%

“…As a treatment option, endolymphatic sac surgery has had a long history since its introduction by Portmann in 1927 [9], but its efficacy has been debated since the 1980s [10]. Our recent modification to the surgery using high-dose steroid instillation into the sac added to a sac-mastoid shunt showed good results in terms of postoperative hearing, as well as vertigo control [11].…”

Section: Introductionmentioning

confidence: 99%

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Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Uno¹,

Imai²,

Watanabe

et al. 2013

Acta Oto-Laryngologica

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Of seven patients with hydrops confirmed by MRI before surgery, both cochlear and vestibular hydrops became negative in two, cochlear hydrops became negative in one, both hydrops were present, but reduced, in one, and there was no change in three patients. The number of vertigo spells was reduced in all cases at 6-12 months after surgery. As for the three cases of negative hydrops, vertigo was completely suppressed. In two cases in which hearing level improved, hydrops became negative after surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Uno¹,

Imai²,

Watanabe

et al. 2013

Acta Oto-Laryngologica

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“…Risiko einer solchen Therapie ist eine zusätzliche cochleäre Schädigung mit Surditas auf dem betroffenen Ohr. Eine Saccotomie zur Dekompression hat lediglich einen Effekt auf Placebo-Niveau [29].…”

Section: Organisch Psychischunclassified

Chronischer Schwindel aus neurologischer Sicht

Obermann

2013

Dtsch med Wochenschr

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Dizziness and vertigo are among the most common symptoms in neurology and medicine in general. The differential diagnosis may be simplified by systematic and careful assessment of presenting symptoms. The most common conditions associated with vertigo and dizziness can be diagnosed by patient history and physical examination alone. Extensive apparative diagnostic work-up is seldomly required and often not helpful. The majority of these disorders can be well treated and have an excellent prognosis, when diagnosed adequately and within a reasonable time frame to prevent the development of chronic disease.

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“…Vertigo persists despite optimal medical therapy in approximately 10% of the patients (Glasscock et al, 1984). The efficacy of surgical procedures such as endolymphatic sac procedures has been questioned based on comparison involving sham surgery (Thomsen et al, 1981). However, there has been recently a revival of this procedure.…”

Section: Managementmentioning

confidence: 99%

Vestibular System Disorders

Fetter

2010

Encyclopedia of Life Sciences

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The vestibular system provides vital sensory information for the control of balance and posture. Vestibular end organs on each side sense linear and angular acceleration in three-dimensional space: the saccule and the utricle (linear motion), and the anterior, posterior and lateral semicircular canals (angular motion) and transduce this information to electrochemical signals. The central nervous system integrates this information from the vestibular system with visual and proprioceptive information to a best possible estimate of the actual movement of the head and body to stabilise gaze during head motion by means of the vestibulo-ocular reflex (VOR) and to control balance by modulation of muscle tone through the vestibulocollic and vestibulospinal reflexes. Disorders of the vestibular system, either peripheral or central, often give rise to the sensory illusion of rotation, vertigo, disequilibrium or imbalance, common symptoms in clinical practice.

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Placebo Effect in Surgery for Meniere's Disease: A Double-blind, Placebo-Controlled Study on Endolymphatic Sac Shunt Surgery

Cited by 215 publications

References 13 publications

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Chronischer Schwindel aus neurologischer Sicht

Vestibular System Disorders

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