Placental bed research: II. Functional and immunological investigations of the placental bed

Harris, Lynda K.; Benagiano, Marisa; D’Elios, Mario Milco; Brosens, Ivo; Benagiano, Giuseppe

doi:10.1016/j.ajog.2019.07.010

Cited by 94 publications

(65 citation statements)

References 208 publications

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“…Moreover, recent studies suggest that additional processes, including invasion of uterine veins and lymph vessels by endo-venous and endo-lymphatic trophoblast cells, respectively, may also be involved in uterine artery remodeling [ 55 , 56 ]. Based on these studies, it has been proposed that the immune system plays a role in uterine vessel transformation, although it has been suggested that the role of the immune system is more established in mouse than in human pregnancy (reviewed in [ 57 – 59 ]).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Regulation of Uterine Spiral Artery Remodeling: a Review

Albrecht

Pepe

2020

Reprod. Sci.

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Extravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth restriction, which result in maternal and fetal morbidity and mortality. Many in vitro studies have been conducted to determine the ability of growth and other factors to stimulate trophoblast cells to migrate across a synthetic membrane. Clinical studies have investigated whether the maternal levels of various factors are altered during abnormal human pregnancy. Animal models have been established to assess the ability of various factors to recapitulate the pathophysiological symptoms of preeclampsia. This review analyzes the results of the in vitro, clinical, and animal studies and describes a nonhuman primate experimental paradigm of defective uterine artery remodeling to study the regulation of vessel remodeling.

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Section: In Vitro Studiesmentioning

confidence: 99%

Regulation of Uterine Spiral Artery Remodeling: a Review

Albrecht

Pepe

2020

Reprod. Sci.

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“…Although extensive studies have been conducted, the etiology of PE remains unknown. However, multiple factors have been implicated, including endothelial 4 , 5 , immunological 6 , and genetic factors 7 , 8 . It has been suggested that an inadequate maternal immunological response to the semiallogenic fetus and consequently abnormal placentation could cause PE.…”

Section: Introductionmentioning

confidence: 99%

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Nishizawa¹,

Kumada²,

Tateno³

et al. 2020

Sci Rep

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Preeclampsia is a pregnancy-induced disorder that is characterized by hypertension and is a leading cause of perinatal and maternal–fetal morbidity and mortality. HLA-G is thought to play important roles in maternal–fetal immune tolerance, and the associations between HLA-G gene polymorphisms and the onset of pregnancy-related diseases have been explored extensively. Because contiguous genomic sequencing is difficult, the association between the HLA-G genotype and preeclampsia onset is controversial. In this study, genomic sequences of the HLA-G region (5.2 kb) from 31 pairs of mother–offspring genomic DNA samples (18 pairs from normal pregnancies/births and 13 from preeclampsia births) were obtained by single-molecule real-time sequencing using the PacBio RS II platform. The HLA-G alleles identified in our cohort matched seven known HLA-G alleles, but we also identified two new HLA-G alleles at the fourth-field resolution and compared them with nucleotide sequences from a public database that consisted of coding sequences that cover the 3.1-kb HLA-G gene span. Intriguingly, a potential association between preeclampsia onset and the poly T stretch within the downstream region of the HLA-G*01:01:01:01 allele was found. Our study suggests that long-read sequencing of HLA-G will provide clues for characterizing HLA-G variants that are involved in the pathophysiology of preeclampsia.

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“…(1/70)). (56) Regarding preterm delivery, previous studies have demonstrated that a subset of pregnant women with spontaneous preterm birth has placental lesions associated with uteroplacental ischemia (97)(98)(99)(100)(101)(102) and abnormal uterine artery Doppler. (103,104) Such findings are frequently observed in women with preeclampsia.…”

Section: Resultsmentioning

confidence: 99%

Does low-dose aspirin initiated before 11 weeks’ gestation reduce the rate of preeclampsia?

Chaemsaithong

Cuenca-Gomez

Plana

et al. 2020

American Journal of Obstetrics and Gynecology

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Condensation: Aspirin given at <11 weeks' gestation in high risk women does not reduce the risk of preeclampsia and gestational hypertension but may reduce the risk of preterm delivery. Short title: Early aspirin administration and preeclampsia PROSPERO registration number: CRD42019125006 AJOG at a Glance: Why was this study conducted? • To perform a systematic review and meta-analysis to evaluate the effect of lowdose aspirin initiated at <11 weeks' gestation on the risk of preeclampsia, gestational hypertension, or any hypertensive disorder of pregnancy. Secondary outcomes included preterm delivery at <37 weeks' gestation and fetal growth restriction. Key findings • The administration of low-dose aspirin at <11 weeks' gestation in women with a history of recurrent pregnancy loss, women who had undergone in vitro fertilization or women with thrombophilia or antiphospholipid syndrome was associated with a non-significant decrease in the risk of preeclampsia, gestational hypertension, and any hypertensive disorder of pregnancy. • Early low-dose aspirin reduced the risk of preterm delivery but had no impact on the risk of fetal growth restriction. • Except for preterm delivery and any hypertensive disorder of pregnancy, sensitivity analysis demonstrated similar observations; confirming the robustness of our analysis. What does this add to what is known? • Administration of low-dose aspirin at <11 weeks' gestation to high risk women does not reduce the risk of preeclampsia, gestational hypertension, any hypertensive disorder of pregnancy and fetal growth restriction but might reduce the risk of preterm delivery at <37 weeks of gestation. ABSTRACT OBJECTIVE DATA: Pre-conception or early administration of low-dose aspirin might improve endometrial growth, placental vascularization and organogenesis. Most studies have evaluated the potential benefit of pre-conception or early administration of low-dose aspirin in women with a history of recurrent pregnancy loss, women who have undergone in vitro fertilization or women with thrombophilia or antiphospholipid syndrome. These women are at an increased risk of placenta-associated complications of pregnancy, including preeclampsia, preterm delivery and fetal growth restriction. STUDY: We performed a systematic review and meta-analysis to evaluate the effect of low-dose aspirin initiated at <11 weeks' gestation on the risk of preeclampsia, gestational hypertension, or any hypertensive disorder of pregnancy. Secondary outcomes included preterm delivery at <37 weeks' gestation and fetal growth restriction. STUDY APPRAISAL AND SYNTHESIS METHODS: We searched in MEDLINE via PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.Gov and the World Health Organization International Clinical Trials Registry Platform (WHO-ICTRP) from 1985 to November 2018. Entry criteria were randomized controlled trials evaluating the effect of aspirin administered at <11 weeks' gestation in preventing preeclampsia and/or hypertensive disorders in pregnancy or improvi...

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Placental bed research: II. Functional and immunological investigations of the placental bed

Cited by 94 publications

References 208 publications

Regulation of Uterine Spiral Artery Remodeling: a Review

Regulation of Uterine Spiral Artery Remodeling: a Review

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Does low-dose aspirin initiated before 11 weeks’ gestation reduce the rate of preeclampsia?

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