Placental disease and abnormal umbilical artery Doppler waveforms in Trisomy 21 Pregnancy: A case-control study

Mone, Fionnuala; Corry, Edward; Segurado, Ricardo; Downey, Paul; McParland, Peter; McAuliffe, Fionnuala M.; Mooney, Eoghan E.

doi:10.1016/j.reprotox.2016.06.104

Cited by 1 publication

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“…In the course of our study, we found a violation of branching and hypovascularization of villi with increased proliferation of fibroblasts in placentas of fetuses with trisomy 21 [15]. These data correlate with the results of the Doppler metric performed in the study by E. Corry et al 2016, where there was a reduction of the vascular bed and impaired perfusion in the placenta in trisomy 21 [3].…”

Section: Discussionsupporting

confidence: 89%

“…At the same time, the volume of the placenta with trisomy 21 does not significantly differ from the volume of the placenta of fetuses with a normal karyotype [4]. In addition, trisomy 21 shows a tendency to form an absolutely short umbilical cord [3]. In placentas with trisomy 18 and 13 a decrease in the vascularization index and blood flow was revealed [5].…”

Section: Introductionmentioning

confidence: 84%

“…According to the literature, placental ultrasound in cases of trisomy 21 shows fetal vascular malperfusion and impaired differentiation of the villous chorion [3]. At the same time, the volume of the placenta with trisomy 21 does not significantly differ from the volume of the placenta of fetuses with a normal karyotype [4].…”

Section: Introductionmentioning

confidence: 99%

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The human placenta and aneuploidy — trisomies 21, 18, 13

Kolobov

Lychyova²,

Карев

et al. 2020

Vestnik SPbSU. Medicine

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The purpose of this research was to investigation the morphological features of human placenta with karyotyped trisomy 21, 18 and 13 chromosomes. The study included 50 placenta of fetuses in miscarriages pregnancy at 19–20 weeks, among them 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 21 of the fetuses; 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 18 of the fetuses; 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 13 in the fetuses; 20 placentas obtained as a result of spontaneous miscarriages without any congenital defects and abnormal karyotype of the fetuses. As a result of the investigation, in placentas with karyotyped trisomies, a violation of villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic changes in villus stroma and inhibition of angiogenesis were noted. As a result of the study, in placentas with karyotyped trisomies, a violation of villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic changes in villus stroma and inhibition of angiogenesis were noted.

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Section: Discussionsupporting

confidence: 89%