Placental spectrum features between mesenchymal dysplasia and partial hydatidiform mole coexisting with a live fetus

Introduction: A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies. The aim of this study was to present a rare case of partial molar pregnancy coexisting with a normal diploid fetus. Case presentation: A 32-year-old woman gravid 3, Para 2 (2 previous cesarean section) was referred to Ghaem hospital, an academic hospital of Mashhad University of Medical Sciences, Mashhad, Iran, in 2020 at 34 weeks of gestation due to labor pain. She had an ultrasound-based diagnosis of partial molar pregnancy with the normal female fetus at 30 weeks for the first time. Due to 2 previous cesarean sections and regular uterine contractions, She underwent cesarean section at 34 weeks and 2 days. A normal female infant with a normal Apgar score was born. The postpartum period is complicated with preeclampsia. The pathological evaluation confirmed partial molar pregnancy. The neonatal Karyotype was 46 XX and the neonatal period was uneventful. Maternal serum β-hCG reached normal after 5 weeks of cesarean. Conclusion: Partial molar pregnancy with the coexisting normal fetus is a rare condition, however, it may complicate the pregnancy outcomes, which affected both mother and fetus. So early diagnosis and close follow-up may prevent catastrophic maternal and fetal complications.

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Partial Molar Pregnancy Coexisting with a Normal Diploid Fetus: A Case Report

Delkhah

Pourali

Mirzaeian

et al. 2023

CWHR

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Ultrasound signs of fetal chromosomal abnormalities at 11–14 weeks of pregnancy and its value in the era of modern genetic testing

Bulanova,

Smirnova,

Panina

2024

jour

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A steady increase in average maternity age at the time of first childbirth lead to a higher risk of fetal chromosomal abnormalities. The Order No. 1130n of the Ministry of Health of the Russian Federation establish the screening protocol at 11–14 weeks of gestation with assessing the followed criteria of fetal chromosomal pathology: the nuchal translucency thickness, nasal bone measurement, ductus venosus pulsatility index, tricuspid regurgitation, and heart rate. The value of non-invasive prenatal testing (NIPT) in the early prenatal diagnosis of the most common chromosomal abnormalities, as the trisomies 21, 18, 13, and monosomy X is also increasing. Additionally, numerous other fetal karyotype abnormalities can also be suspected at 11–14 weeks of gestation by revealing a number of other ultrasound signs. The article presents the literature review on additional ultrasound signs of various, both more and less common, chromosomal abnormalities. Pathological signs, abnormalities of fetal anatomy and extrafetal structures in the first trimester, which could be used as additional ultrasound signs of chromosomal pathology of various organs and systems (central nervous system and head, heart and blood vessels, urinary system, abdominal organs, fetal skeleton, as well as the placenta, umbilical cord, amniotic membranes) are described in the article. Despite the use of NIPT, including its extended panels, there remains a need to use ultrasound to detect the signs of rarer, but no less significant chromosomal pathologies, such as triploidies, mosaic trisomies, rare autosomal trisomies, duplications, and deletions.

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Placental spectrum features between mesenchymal dysplasia and partial hydatidiform mole coexisting with a live fetus

Cited by 2 publications

References 12 publications

Partial Molar Pregnancy Coexisting with a Normal Diploid Fetus: A Case Report

Partial Molar Pregnancy Coexisting with a Normal Diploid Fetus: A Case Report

Ultrasound signs of fetal chromosomal abnormalities at 11–14 weeks of pregnancy and its value in the era of modern genetic testing

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