Planar gamma scintigraphy—points to consider when quantifying pulmonary dry powder aerosol deposition

Bondesson, Eva; Bengtsson, Thomas; Borgström, Lars; Nilsson, Lars Erik; Norrgren, Kristina; Trofast, Eva; Wollmer, Per

doi:10.1016/s0378-5173(02)00579-3

Cited by 14 publications

(10 citation statements)

References 16 publications

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“…Counts were corrected for attenuation correction factor, lung clearance, and time for elimination of radioactivity from the lungs. The amount of drug deposited into the lungs was calculated based upon the counts of radioactivity in the formulation (83,84). Analysis of the images yielded data for the lungs, oropharynx, trachea, and inhalation device in terms of radioactive counts, termed as "primary counts" (85).…”

Section: In Vivo Pulmonary Deposition Pattern Of Developed Conventionmentioning

confidence: 99%

“…The amount of drug deposited into the lungs was calculated based upon the counts of radioactivity in the formulation (83,84). Analysis of the images yielded data for the lungs, oropharynx, trachea, and inhalation device in terms of radioactive counts, termed as "primary counts" (85). As gamma rays pass through the body to the gamma camera, they are absorbed and scattered by different body tissues through which they pass.…”

Section: In Vivo Pulmonary Deposition Pattern Of Developed Conventionmentioning

confidence: 99%

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Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study

et al. 2009

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Abstract. The purpose of this research was to generate, characterize, and investigate the in vivo efficacy of budesonide (BUD) microparticles prepared by spray-drying technology with a potential application as carriers for pulmonary administration with sustained-release profile and improved respirable fraction. Microspheres and porous particles of chitosan (drug/chitosan, 1:2) were prepared by spray drying using optimized process parameters and were characterized for different physicochemical parameters. Mass median aerodynamic diameter and geometric standard deviation for conventional, microspheres, and porous particles formulations were 2.75, 4.60, and 4.30 µm and 2.56, 1.75, and 2.54, respectively. Pharmacokinetic study was performed in rats by intratracheal administration of either placebo or developed dry powder inhalation (DPI) formulation. Pharmacokinetic parameters were calculated (Ka, Ke, T max , C max , AUC, and Vd) and these results indicated that developed formulations extended half life compared to conventional formulation with onefold to fourfold improved local and systemic bioavailability. Estimates of relative bioavailability suggested that developed formulations have excellent lung deposition characteristics with extended T 1/2 from 9.4 to 14 h compared to conventional formulation. Anti-inflammatory activity of BUD and developed formulations was compared and found to be similar. Cytotoxicity was determined in A549 alveolar epithelial cell line and found to be not toxic. In vivo pulmonary deposition of developed conventional formulation was studied using gamma scintigraphy and results indicated potential in vitro-in vivo correlation in performance of conventional BUD DPI formulation. From the DPI formulation prepared with porous particles, the concentration of BUD increased fourfold in the lungs, indicating pulmonary targeting potential of developed formulations.

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Section: In Vivo Pulmonary Deposition Pattern Of Developed Conventionmentioning

confidence: 99%

Section: In Vivo Pulmonary Deposition Pattern Of Developed Conventionmentioning

confidence: 99%

Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study

et al. 2009

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“…Gamma scintigraphy can be used to measure the distribution of aerosols within the lung [65][66][67][68]. The lack of spatial resolution of gamma scintigraphy has generally limited the measurement of the distribution of aerosol deposition to statistical metrics, such as the penetration index (the ratio of peripheral to central deposition), the coefficient of variation, the coefficient of skewness and the quotient between maximum and mean value deposition [66].…”

Section: Nuclear Medical Imagingmentioning

confidence: 99%

Imaging regional lung function: A critical tool for developing inhaled antimicrobial therapies

Dubsky

Fouras

2015

Advanced Drug Delivery Reviews

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Alterations in regional lung function due to respiratory infection have a significant effect on the deposition of inhaled treatments. This has consequences for treatment effectiveness and hence recovery of lung function. In order to advance our understanding of respiratory infection and inhaled treatment delivery, we must develop imaging techniques that can provide regional functional measurements of the lung. In this review, we explore the role of functional imaging for the assessment of respiratory infection and development of inhaled treatments. We describe established and emerging functional lung imaging methods. The effect of infection on lung function is described, and the link between regional disease, function, and inhaled treatments is discussed. The potential for lung function imaging to provide unique insights into the functional consequences of infection, and its treatment, is also discussed.

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“…Absorption of inhaled medication into the rest of the body is minimal. Therefore, adverse side effects are fewer as compared to oral medications [1][2][3][4] . For the management of asthma, methylxanthines play an important role through the inhibition of phosphodiesterase activities.…”

Section: Introductionmentioning

confidence: 99%

Liposome: A Novel Aerosol Carrier of Doxophylline in Treatment of Chronic Asthma & Chronic Obstructive Pulmonary Disease

Oberoi¹,

Choudhry²,

Patel³

et al. 2012

Int Jour of Biomed Res

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The aim of the present research work is to develop liposomal dry powder inhaler of doxophylline by double hydration method to increase the entrapment efficiency of this hydrophilic drug. In this formulation, PVP coated mannitol and the mannitol were used as a cryoprotectant and a carrier respectively. Doxophylline, a new methylxanthine derivative, chemically designated as 7-(1,3-dixolan-2-yl-methyl) theophylline, is a more potent bronchodilator than theophylline, which is associated with a wide range of adverse effects accounting for poor compliance and high dropout rates. Powder inhaler formulation of the drug was characterized by angle of repose, compressibility index and in vitro aerosolization properties using Anderson cascade impactor including fine particle dose (212.9+7.2), fine particle fraction (21.69+1.21), % dispersibility (62.34+3.5) and % emission (72.1+0.13) at a flow rate of 28.3 lit/m for 10 seconds using 10 capsules for each determinations. The optimized formulations were subjected to stability studies at 2-8 o C, RT, and 40 o C for 3 months. The stability studies of LDPI were determined in terms of their visual appearance (surface characteristics and colour changes) and PDRE. The in vivo study was carried out by gamma scintigraphy and that showed better retention of doxophylline in liposomal formulation as compared to the controlled release formulation.

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Planar gamma scintigraphy—points to consider when quantifying pulmonary dry powder aerosol deposition

Cited by 14 publications

References 16 publications

Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study

Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study

Imaging regional lung function: A critical tool for developing inhaled antimicrobial therapies

Liposome: A Novel Aerosol Carrier of Doxophylline in Treatment of Chronic Asthma & Chronic Obstructive Pulmonary Disease

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