Plant-Based Bioinsecticides for Mosquito Control: Impact on Insecticide Resistance and Disease Transmission

Demirak, Meryem Şenay Şengül; Canpolat, Emel

doi:10.3390/insects13020162

Cited by 108 publications

(65 citation statements)

References 186 publications

(196 reference statements)

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“…This is probably because its chains are easily entangled in multiple configurations and associated with different protein binding sites. Phytol strikes the insect nervous system and causes neurotoxic effects through several mechanisms by inhibiting AChE activity 36 – 39 , agonist effects like benzodiazepines, producing sedative and anxiolytic activities the GABAa receptor 40 , 41 , and agonist of octopamine receptors 42 .…”

Section: Resultsmentioning

confidence: 99%

Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol

Correa

Carvalho

Oliveira

et al. 2023

Sci Rep

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Essential oils (EOs) are a promising source for novel environmentally safe insecticides. However, the structural diversity of their compounds poses challenges to accurately elucidate their biological mechanisms of action. We present a new chemoinformatics methodology aimed at predicting the impact of essential oil (EO) compounds on the molecular targets of commercial insecticides. Our approach merges virtual screening, chemoinformatics, and machine learning to identify custom signatures and reference molecule clusters. By assigning a molecule to a cluster, we can determine its most likely interaction targets. Our findings reveal that the main targets of EOs are juvenile hormone-specific proteins (JHBP and MET) and octopamine receptor agonists (OctpRago). Three of the twenty clusters show strong similarities to the juvenile hormone, steroids, and biogenic amines. For instance, the methodology successfully identified E-Nerolidol, for which literature points indications of disrupting insect metamorphosis and neurochemistry, as a potential insecticide in these pathways. We validated the predictions through experimental bioassays, observing symptoms in blowflies that were consistent with the computational results. This new approach sheds a higher light on the ways of action of EO compounds in nature and biotechnology. It also opens new possibilities for understanding how molecules can interfere with biological systems and has broad implications for areas such as drug design.

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Section: Resultsmentioning

confidence: 99%

Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol

Correa

Carvalho

Oliveira

et al. 2023

Sci Rep

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show abstract

“…This means that elevated esterases can detoxify the insecticides. Gene amplification is the cause of the increased production of these enzymes ( Şengül Demirak and Canpolat, 2022 ). In mosquitoes, amplified esterase molecules are more reactive with insecticides than non-amplified esterases ( Gan et al, 2021 ).…”

Section: Resistance In Invasive Insectsmentioning

confidence: 99%

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

et al. 2023

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Threatening the global community is a wide variety of potential threats, most notably invasive pest species. Invasive pest species are non-native organisms that humans have either accidentally or intentionally spread to new regions. One of the most effective and first lines of control strategies for controlling pests is the application of insecticides. These toxic chemicals are employed to get rid of pests, but they pose great risks to people, animals, and plants. Pesticides are heavily used in managing invasive pests in the current era. Due to the overuse of synthetic chemicals, numerous invasive species have already developed resistance. The resistance development is the main reason for the failure to manage the invasive species. Developing pesticide resistance management techniques necessitates a thorough understanding of the mechanisms through which insects acquire insecticide resistance. Insects use a variety of behavioral, biochemical, physiological, genetic, and metabolic methods to deal with toxic chemicals, which can lead to resistance through continuous overexpression of detoxifying enzymes. An overabundance of enzymes causes metabolic resistance, detoxifying pesticides and rendering them ineffective against pests. A key factor in the development of metabolic resistance is the amplification of certain metabolic enzymes, specifically esterases, Glutathione S-transferase, Cytochromes p450 monooxygenase, and hydrolyses. Additionally, insect guts offer unique habitats for microbial colonization, and gut bacteria may serve their hosts a variety of useful services. Most importantly, the detoxification of insecticides leads to resistance development. The complete knowledge of invasive pest species and their mechanisms of resistance development could be very helpful in coping with the challenges and effectively developing effective strategies for the control of invasive species. Integrated Pest Management is particularly effective at lowering the risk of chemical and environmental contaminants and the resulting health issues, and it may also offer the most effective ways to control insect pests.

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“…Traditionally, vector control programs were focused on eliminating mosquitoes using various insecticides [ 4 , 5 ]. However, insecticide resistance was noted in many mosquito vectors, including Aedes aegypti [ 6 , 7 , 8 ]. This species has been found to be resistant to the majority of insecticide classes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a New Self-Marking Technique in Aedes aegypti under Laboratory Conditions

Diouf

Seck

Fall

et al. 2022

Insects

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In the implementation of mosquito control strategy programs using Sterile Insect Technique and other rear and release strategies, knowledge on the dispersion, competitiveness and survival of mosquitos is considered essential. To assess these parameters, marking techniques are generally used to differentiate colony mosquitoes from wild ones. Most of the existing mosquito marking methods require numerous manipulations that can impact their quality. In this study, we have developed a self-marking technique that can reduce the damage associated with mosquito handling. The marking technique consisted of adding fluorescent powder (DayGlo: A-17-N Saturn yellow) directly to the surface water of the receptacle containing Aedes aegypti male pupae. Different quantities of powder were used, and marking efficacy, powder persistence and mosquito survival were assessed. The results show a mean marking rate of 98 ± 1.61%, and the probability of marking increased significantly (p < 0.001) with increasing concentrations of fluorescent powder. Fluorescent powder persisted up to 20 days and did not induce a negative effect on mosquito survival (χ2 = 5.3, df = 7, p = 0.63). In addition, powder transfer did not occur between marked and unmarked populations. This marking method significantly reduces human intervention and mosquito handling during the marking process, improving the quality of marked mosquitoes used to assess SIT programs.

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Plant-Based Bioinsecticides for Mosquito Control: Impact on Insecticide Resistance and Disease Transmission

Cited by 108 publications

References 186 publications

Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol

Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

Effectiveness of a New Self-Marking Technique in Aedes aegypti under Laboratory Conditions

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