Plant cell culture technologies: A promising alternatives to produce high-value secondary metabolites

Abdulhafiz, Ferid

doi:10.1016/j.arabjc.2022.104161

Cited by 31 publications

(15 citation statements)

References 65 publications

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“…A callus is typically heterogeneous. Cell suspensions are a potential source of high-value plant-derived bioactive compounds [ 97 , 98 ]. Cell suspensions encompass a homogeneous cell population, which produces uniform and rapid nutrient and plant growth regulators.…”

Section: Plant Tissue Culture Techniques For the Production Of Valuab...mentioning

confidence: 99%

“…They also easily accommodate several biotechnological strategies such as elicitation, precursor feeding, and bioconversion or biotransformation, as well as mass production in bioreactors (scale-up) [ 7 ]. Several important plant-derived bioactive compounds have been produced using callogenesis and cell suspension technologies, whereby the majority were obtained using cell suspensions [ 98 ]. The main PDBCs that have been produced using cell suspensions are Echinan 4 P, Acetos 10 P, Teoside 10, and Teupol 50 P [ 99 , 100 ].…”

Section: Plant Tissue Culture Techniques For the Production Of Valuab...mentioning

confidence: 99%

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Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects

Bouzroud

Maaiden

Sobeh

et al. 2023

IJMS

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Plants are the main source of bioactive compounds that can be used for the formulation of cosmetic products. Plant extracts have numerous proven health benefits, among which are anti-ageing and skin-care properties. However, with the increased demand for plant-derived cosmetic products, there is a crucial prerequisite for establishing alternative approaches to conventional methods to ensure sufficient biomass for sustainable production. Plant tissue culture techniques, such as in vitro root cultures, micropropagation, or callogenesis, offer the possibility to produce considerable amounts of bioactive compounds independent of external factors that may influence their production. This production can also be significantly increased with the implementation of other biotechnological approaches such as elicitation, metabolic engineering, precursor and/or nutrient feeding, immobilization, and permeabilization. This work aimed to evaluate the potential of biotechnological tools for producing bioactive compounds, with a focus on bioactive compounds with anti-ageing properties, which can be used for the development of green-label cosmeceutical products. In addition, some examples demonstrating the use of plant tissue culture techniques to produce high-value bioactive ingredients for cosmeceutical applications are also addressed, showing the importance of these tools and approaches for the sustainable production of plant-derived cosmetic products.

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Section: Plant Tissue Culture Techniques For the Production Of Valuab...mentioning

confidence: 99%

Section: Plant Tissue Culture Techniques For the Production Of Valuab...mentioning

confidence: 99%

Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects

Bouzroud

Maaiden

Sobeh

et al. 2023

IJMS

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“…To address these challenges, plant tissue culture offers an alternative method for the quick and efficient production of secondary metabolites in a controlled environment without being limited by seasons [ 8 ]. Callus culture is particularly effective in obtaining commercially valuable secondary metabolites as callus can be induced from small plant segments, allowing for the direct isolation of secondary metabolites or pharmaceuticals without harming the entire plant [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Variation of antibacterial and antioxidant secondary metabolites and volatiles in leaf and callus extracts of Phulai (Acacia Modesta Wall.)

Hagaggi,

Abdul-Raouf,

Radwan

2024

BMC Plant Biol

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Background Acacia species are economically significant as medicinal plants that have been utilized since ancient times. Acacia modesta has been reported to possess potent antibacterial and antioxidant properties, but its growth rate is slow. In this study, we hypothesized that inducing callus in vitro from A. modesta could enhance the production of antibacterial and antioxidant secondary metabolites, thereby circumventing the issues of slow growth and excessive harvesting of the plant. Results The callus was induced from axillary buds on MS medium supplemented with 1 mg/L of 2,4-D and 1 mg/L of BAP. The secondary metabolites, volatile compounds, antibacterial activity, and antioxidant activity of the callus and parent plant leaf extracts were evaluated. The results revealed that the content of phenolics and flavonoids, the number of volatile compounds, and the antibacterial and antioxidant activities of the callus extract were significantly enhanced (P ≤ 0.05) compared to the leaf extract. The antibacterial and antioxidant effects were strongly correlated with the total phenolic and flavonoid content in the extracts. Conclusions Our findings suggest that in vitro callus culture increases the production of phenolics, flavonoids, and volatile compounds. This subsequently enhances the antibacterial and antioxidant properties of A. modesta.

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“…These metabolites serve various functions, such as defense against pests and pathogens, adaptation to environmental stressors, and communication with other organisms [ 1 , 2 ]. Several secondary metabolites include saponins, polysaccharides, flavonoids, and phenolic compounds [ 3 ]. Each category has distinct chemical structures and biological activities, contributing to their overall medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

Sustainable production of natural products using synthetic biology: Ginsenosides

Son,

Kang,

Shin

et al. 2024

Journal of Ginseng Research

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Plant cell culture technologies: A promising alternatives to produce high-value secondary metabolites

Cited by 31 publications

References 65 publications

Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects

Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects

Variation of antibacterial and antioxidant secondary metabolites and volatiles in leaf and callus extracts of Phulai (Acacia Modesta Wall.)

Sustainable production of natural products using synthetic biology: Ginsenosides

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