Plant Dependent Mutation Assays

Gentile, James M.; Plewa, Michael J.

doi:10.1007/978-1-4684-4352-3_24

Genetic Toxicology 1982

DOI: 10.1007/978-1-4684-4352-3_24

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Plant Dependent Mutation Assays

James M. Gentile

Michael J. Plewa

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1985

1988

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Cited by 2 publications

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In vitro enhancement of the mutagenicity of 4‐nitro‐o‐phenylenediamine by plant S‐9

Gentile

Townsend

et al. 1985

Environ. mutagen

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The direct-acting mutagen 4-nitro-o-phenylenediamine (NOP) was activated in vitro by pea or tobacco S-9 into a more potent mutagen in Salmonella typhimurium strain TA98. NOP mutagenicity was not altered by Aroclor 1254-induced rat liver S-9. The plant S-9 activation of NOP was heat-sensitive but was not NADPH-dependent, did not involve superoxide radicals, and was not inhibited by CO. A direct relationship between plant peroxidase and NOP activation was established. Several purified peroxidases including horseradish peroxidase, chloroperoxidase, and lactoperoxidase also activated NOP. The perodoxidative process was not H2O2-dependent but was partially inhibited by a peroxidase inhibitor.

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In vitro enhancement of the mutagenicity of 4‐nitro‐o‐phenylenediamine by plant S‐9

Gentile

Townsend

et al. 1985

Environ. mutagen

Self Cite

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show abstract

Mutagenic activity of promutagens in plants: indirect evidence of their activation

Velemínský

Gichner

1988

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Plant Dependent Mutation Assays

Cited by 2 publications

References 48 publications

In vitro enhancement of the mutagenicity of 4‐nitro‐o‐phenylenediamine by plant S‐9

In vitro enhancement of the mutagenicity of 4‐nitro‐o‐phenylenediamine by plant S‐9

Mutagenic activity of promutagens in plants: indirect evidence of their activation

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