Plant exosome nanovesicles (PENs): green delivery platforms

Cao, Min; Diao, Ningning; Cai, Xiaolu; Chen, Xing; Xiao, Yi; Guo, Chunjing; Chen, Daquan; Zhang, Xingcai

doi:10.1039/d3mh01030a

Cited by 46 publications

(14 citation statements)

References 158 publications

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“…Researchers in the yellow region, including Penglong Wang, Haimin Lei, and Xuemei Huang, have focused on the self-assembly structures and supramolecular nanostructures of natural medicines [ 65 , 66 ]. In the brown region, Professor Daquan Chen and his team from Yantai University primarily conducted studies on targeted nanodelivery systems for TCM and their extracts [ 67 – 69 ]. They explored various systems, including plant-derived exosome-like vesicles, macrophage membrane biomimetic nanoparticles, and nanomicelles, for delivering natural bioactive products.…”

Section: Discussionmentioning

confidence: 99%

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Ai,

Li,

Zheng

et al. 2024

J Nanobiotechnol

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Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal nanoparticles lead to improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that herbal medicine nanomaterials are rapidly advancing and making significant progress; however, bibliometric analysis and knowledge mapping for herbal nanoparticles are currently lacking. We performed a bibliometric analysis by retrieving publications related to herbal nanoparticles from the Web of Science Core Collection (WoSCC) database spanning from 2004 to 2023. Data processing was performed using the R package Bibliometrix, VOSviewers, and CiteSpace. Results In total, 1876 articles related to herbal nanoparticles were identified, originating from various countries, with China being the primary contributing country. The number of publications in this field increases annually. Beijing University of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, and Saveetha University in India are prominent research institutions in this domain. The Journal “International Journal of Nanomedicine” has the highest number of publications. The number of authors of these publications reached 8234, with Yan Zhao, Yue Zhang, and Huihua Qu being the most prolific authors and Yan Zhao being the most frequently cited author. “Traditional Chinese medicine,” “drug delivery,” and “green synthesis” are the main research focal points. Themes such as “green synthesis,” “curcumin,” “wound healing,” “drug delivery,” and “carbon dots” may represent emerging research areas. Conclusions Our study findings assist in identifying the latest research frontiers and hot topics, providing valuable references for scholars investigating the role of nanotechnology in herbal medicine. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Ai,

Li,

Zheng

et al. 2024

J Nanobiotechnol

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“…Machine learning has greatly advanced biomedical research. − A flowchart of the machine-learning process is shown in Figure d. PCA is used to process spectral data with high dimensions, and by calculating the covariance matrix of spectral data, the correlation between different wavelength points can be analyzed.…”

Section: Methodsmentioning

confidence: 99%

Minimum Minutes Machine-Learning Microfluidic Microbe Monitoring Method (M7)

Yang,

Song,

Xiao

et al. 2024

ACS Nano

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Frequent outbreaks of viral diseases have brought substantial negative impacts on society and the economy, and they are very difficult to detect, as the concentration of viral aerosols in the air is low and the composition is complex. The traditional detection method is manually collection and re-detection, being cumbersome and time-consuming. Here we propose a virus aerosol detection method based on microfluidic inertial separation and spectroscopic analysis technology to rapidly and accurately detect aerosol particles in the air. The microfluidic chip is designed based on the principles of inertial separation and laminar flow characteristics, resulting in an average separation efficiency of 95.99% for 2 μm particles. We build a microfluidic chip composite spectrometer detection platform to capture the spectral information on aerosol particles dynamically. By employing machine-learning techniques, we can accurately classify different types of aerosol particles. The entire experiment took less than 30 min as compared with hours by PCR detection. Furthermore, our model achieves an accuracy of 97.87% in identifying virus aerosols, which is comparable to the results obtained from PCR detection.

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“…The vesicles released in this manner are referred to as ELNs. (Figure 2) [8–11]; (2) Exocyst‐positive organelle (EXPO) pathway: Expo‐mediated secretion, autophagy‐mediated secretion, and vacuole‐ plasma Membrane fusion are all mechanisms of protein release that occur within cells. EXPO and autophagy are spherical double‐membrane organelles.…”

Section: Biogenesis Of Pensmentioning

confidence: 99%

A review on separation and application of plant‐derived exosome‐like nanoparticles

Liu,

Xiao,

Wang

et al. 2024

J of Separation Science

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Exosomes‐like nanoparticles (ELNs) (exosomes or extracellular vesicles) are vesicle‐like bodies secreted by cells. Plant ELNs (PENs) are membrane vesicles secreted by plant cells, with a lipid bilayer as the basic skeleton, enclosing various active substances such as proteins and nucleic acids, which have many physiological and pathological functions. Recent studies have found that the PENs are widespread within different plant species and their biological functions are increasingly recognized. The effective separation method is also necessary for its function and application. Ultracentrifugation, sucrose density gradient ultracentrifugation, ultrafiltration, polymer‐based precipitation methods, etc., are commonly used methods for plant exosome‐like nanoparticle extraction. In recent years, emerging methods such as size exclusion chromatography, immunoaffinity capture‐based technique, and microfluidic technology have shown advancements compared to traditional methods. The standardized separation process for PENs continues to evolve. In this review, we summarized the recent progress in the biogenesis, components, separation methods, and some functions of PENs. When the research on the separation method of PENs and their unique biological structure is further studied. A brand‐new idea for the efficient separation and utilization of PENs can be provided in the future, which has a very broad prospect.

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Plant exosome nanovesicles (PENs): green delivery platforms

Abstract: Natural plants have been gaining increasing attention in biomedical research due to their numerous benefits. One of the plant's components, plant exosome-derived vesicles, are small nanoscale vesicles secreted by plant...

Cited by 46 publications

References 158 publications

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Minimum Minutes Machine-Learning Microfluidic Microbe Monitoring Method (M7)

A review on separation and application of plant‐derived exosome‐like nanoparticles

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