Plant expressed EtMIC2 is an effective immunogen in conferring protection against chicken coccidiosis

Subunit Vaccine Based on Plant Expressed Recombinant Eimeria Gametocyte Antigen Gam82 Elicit Protective Immune Response against Chicken Coccidiosis

“…Our earlier work showed that the recombinant EtMIC1 and EtMIC2 protein expressed in plants elicit potent immune response which can be used as a subunit vaccine to control coccidiosis [7,24]. Earlier studies showed that the antibodies raised against gametocyte antigens play a major role in protection against homologous challenge [25,26]. The results obtained by immunizing E. coli produced recombinant Gam82 protein [23] are consistent with our results.…”

Utility of Feed Enzymes and Yeast Derivatives in Ameliorating Deleterious Effects of Coccidiosis on Intestinal Health and Function in Broiler Chickens

“…In other investigations, S. cerevisiae was investigated as oral Eimeria vaccine delivery vehicle commensurate to previous successful delivery of oral viral vaccines (126,127). In this context, a microneme protein (EtMic2) of E. tenella that is intimately involved in host-cell invasion (128) was expressed on the surface of live S. cerevisiae cells (129). The whole yeast cells without or with EtMic2 on their surfaces was used as a live oral vaccine against E. tenella challenge in pullets.…”

Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge

“…Till now, a serious of microneme proteins of E. tenella have been cloned and their immunogenicity and functions have been tested [22][23][24]. However, few studies on E. maxima microneme proteins have been reported.…”