Plant extracts with putative hepatotoxicity activity

Saravanapriya, Palaniappan; Devi, Kasi Pandima

doi:10.1016/b978-0-12-816488-4.00002-4

Cited by 3 publications

(2 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As S. alexandrina is widely used as a laxative agent, some studies have investigated the hepatotoxicity of this valuable herbal medicine. On the basis of the literature review, S. alexandrina has been associated with hepatotoxicity [41]. In addition, the safety of sennosides has been evaluated in a wide range of toxicity experiments.…”

Section: Senna Italica Senna Alexandrinamentioning

confidence: 99%

Comparative LC-ESIMS-Based Metabolite Profiling of Senna italica with Senna alexandrina and Evaluating Their Hepatotoxicity

et al. 2023

View full text Add to dashboard Cite

Senna Mill. (Fabaceae) is an important medicinal plant distributed worldwide. Senna alexandrina (S. alexandrina), the officinal species of the genus, is one of the most well-known herbal medicines traditionally used to treat constipation and digestive diseases. Senna italica (S. italica), another species of the genus, is native to an area ranging from Africa to the Indian subcontinent, including Iran. In Iran, this plant has been used traditionally as a laxative. However, very little phytochemical information and pharmacological reports investigating its safety of use are available. In the current study, we compared LC-ESIMS metabolite profiles of the methanol extract of S. italica with that of S. alexandrina and measured the content of sennosides A and B as the biomarkers in this genus. By this, we were able to examine the feasibility of using S. italica as a laxative agent like S. alexandrina. In addition, the hepatotoxicity of both species was evaluated against HepG2 cancer cell lines using HPLC-based activity profiling to localize the hepatotoxic components and evaluate their safety of use. Interestingly, the results showed that the phytochemical profiles of the plants were similar but with some differences, particularly in their relative contents. Glycosylated flavonoids, anthraquinones, dianthrones, benzochromenones, and benzophenones constituted the main components in both species. Nevertheless, some differences, particularly in the relative amount of some compounds, were observed. According to the LC-MS results, the amounts of sennoside A in S. alexandrina and S. italica were 1.85 ± 0.095% and 1.00 ± 0.38%, respectively. Moreover, the amounts of sennoside B in S. alexandrina and S. italica were 0.41 ± 0.12 % and 0.32 ± 0.17%, respectively. Furthermore, although both extracts showed significant hepatotoxicity at concentrations of 50 and 100 µg/mL, they were almost non-toxic at lower concentrations. Taken together, according to the results, the metabolite profiles of S. italica and S. alexandrina showed many compounds in common. However, further phytochemical, pharmacological, and clinical studies are necessary to examine the efficacy and safety of S. italica as a laxative agent.

show abstract

Section: Senna Italica Senna Alexandrinamentioning

confidence: 99%

Comparative LC-ESIMS-Based Metabolite Profiling of Senna italica with Senna alexandrina and Evaluating Their Hepatotoxicity

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Cassia acutifolia, which is commonly known as Alexandrian senna [1] is a medicinal herb belong to family of Leguminosae which is the 3 rd largest plant family in their number of species , have nearly 765 genera and about 20,000 species [2]. Alexendrian is first originated in eastward to Somalia from some wild plants it is also naturally originates in Asia from Arabian peninsula to India and Seri lanka [3].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Anti-Oxidant Investigation of Alexandrian senna L. Leaves Cultivated in Iraq

Al-Naqqash

Tawfeeq

Eldalawy

2023

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Cassia acutifolia, which is commonly known as Alexandrian senna is a medicinal herb belong to family of Leguminosae, The famous use of this herbal shrub is as a laxative act by stimulation intestinal muscles to contract cause the rapid removal of waste matter. Several phytoconstituents present in Senna leaves mostly contain dianthrone glycosides one of anthraquinone derivates. Two crystalline anthraquinone glucosides sennoside A & B have been reported rich in the leaves and pods, in addition to many flavonoids and terpens. this study was designed to investigate the phytochemical component and antioxidant activity of Alexandrian senna L. leaves cultivated in Iraq. this is done by extraction of plant leaves after drying using hexane then ethanol through soxhlet extractor and determine the active ingredient in the leaves extracts using standards chemical test then the antioxindant activity has been evaluated using DPPH scavenging method. The results indicate the presence of important active ingredient such as flavonoids, saponin, carbohydrate, tannin, terpenoid and alkaloids and the leaves extract show a significant anti-oxidant activity at low level with IC50 26.7 as compared with their standard ascorbic acid.

show abstract

Antioxidant therapy for hepatic diseases: a double-edged sword

Das,

Nerune,

Das

2024

Journal of Basic and Clinical Physiology and Pharmacology

View full text Add to dashboard Cite

Liver diseases are complex conditions, significantly influenced by oxidative stress. This comprehensive review assesses the therapeutic role of antioxidants like l-ascorbic acid and α tocopherol, beta-carotene, various minerals, and plant-based ingredients in mitigating oxidative stress-induced liver diseases. The manuscript delves into the critical influence of genetic and epigenetic factors on disease susceptibility, progression, and response to antioxidant therapy. While animal studies suggest antioxidant efficacy in liver disease treatment, human trials remain inconclusive, and caution is advised due to its possible potential pro-oxidant effects. Moreover, the interactions of antioxidants with other drugs necessitate careful consideration in the management of polypharmacy in liver disease patients. The review underscores the need for further research to establish the clinical benefits of antioxidants with understanding of possible antioxidant toxicities to elucidate the intricate interplay of genetic, epigenetic, and environmental factors in liver diseases. The aim is to foster a better understanding of the knowledge on hepatic disease management with judicial antioxidant therapies.

show abstract

Plant extracts with putative hepatotoxicity activity

Cited by 3 publications

References 137 publications

Comparative LC-ESIMS-Based Metabolite Profiling of Senna italica with Senna alexandrina and Evaluating Their Hepatotoxicity

Comparative LC-ESIMS-Based Metabolite Profiling of Senna italica with Senna alexandrina and Evaluating Their Hepatotoxicity

Phytochemical and Anti-Oxidant Investigation of Alexandrian senna L. Leaves Cultivated in Iraq

Antioxidant therapy for hepatic diseases: a double-edged sword

Contact Info

Product

Resources

About