Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

Shen, Nan; Wang, Tongfei; Gan, Quan; Liu, Sian; Wang, Li; Jin, Biao

doi:10.1016/j.foodchem.2022.132531

Cited by 956 publications

(580 citation statements)

References 130 publications

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“…Apigenin has been described as a free radical scavenger, with the ability to regulate the antioxidant defense in pancreatic cells. Moreover, apigenin is capable of exerting an antioxidant effect in pancreatic cells [ 52 ]. The antioxidant effect of apigenin is associated with significant anti-inflammatory effects, as reported by Ginwala et al [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Calvo

Martín-Diana

Rico

et al. 2022

Foods

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This study aims to determine the potential antioxidant, antihypertensive, hypoglycaemic and nootropic activity of a purified polyphenolic extract from the halophyte ice plant (Mesembryanthemum crystallinum). The ice plant extract showed good antioxidant activity measured by DPPH, ORAC, TEAC, FRAP and ferrous ion chelating activity. Moreover, the extract showed potent ACE, DPP-IV and PEP-inhibitory activity (90.5%, 98.6 % and 73.1%, respectively, at a final concentration of 1 mg/mL). The extract was fractionated and the fraction with the highest content of total phenolic compounds showed the highest bioactivity, suggesting that polyphenols could be mainly responsible for the abovementioned activities. The tentative polyphenol identification by HPLC-ESI-QTOF-MS in this fraction revealed that flavones (>65%) are the major group, with apigenin (38%) predominating, followed by diosmin (17.7%) and luteolin (11.9%). They could presumably be the main elements responsible for the enzymatic inhibition activity. Additionally, 4-hydroxybenzoic acid, p-coumaric acid and a hydroxycinnamic acid derivative (2-O-(p-cumaroyl)-l-malic acid) were found in the extract. To our knowledge, this is the first time that some of these activities have been reported for halophyte extracts.

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Section: Resultsmentioning

confidence: 99%

“…The antioxidant effect of apigenin is associated with significant anti-inflammatory effects, as reported by Ginwala et al [ 53 ]. As well, luteolin exerts a potent antioxidant effect, mediated by the high number of OH groups in the B ring [ 52 ]. Diosmin has been reported as a potent antioxidant in in vitro and in vivo studies [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Calvo

Martín-Diana

Rico

et al. 2022

Foods

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“…In addition, melatonin may regulate flavonoids to mediate light tolerance ( Wei et al, 2019 ; Nazir et al, 2020 ). Flavonoids are also important antioxidants ( Shen et al, 2022 ), however, the interaction of melatonin and flavonoids need further investigation.…”

Section: Roles Of Melatonin In Plant Abiotic Stress Responsesmentioning

confidence: 99%

Melatonin-Mediated Abiotic Stress Tolerance in Plants

Zeng

Mostafa

et al. 2022

Front. Plant Sci.

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Melatonin is a multi-functional molecule that is ubiquitous in all living organisms. Melatonin performs essential roles in plant stress tolerance; its application can reduce the harmful effects of abiotic stresses. Plant melatonin biosynthesis, which usually occurs within chloroplasts, and its related metabolic pathways have been extensively characterized. Melatonin regulates plant stress responses by directly inhibiting the accumulation of reactive oxygen and nitrogen species, and by indirectly affecting stress response pathways. In this review, we summarize recent research concerning melatonin biosynthesis, metabolism, and antioxidation; we focus on melatonin-mediated tolerance to abiotic stresses including drought, waterlogging, salt, heat, cold, heavy metal toxicity, light and others. We also examine exogenous melatonin treatment in plants under abiotic stress. Finally, we discuss future perspectives in melatonin research and its applications in plants.

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“…For example, isoflavones have strong antioxidant capabilities and can protect DNA from free radical damage. Genistein and daidzein are two significant and efficient antioxidants found in soy isoflavones [ 11 ]. Second, some transcription factors have been confirmed to be the main players in water stress signals, including MYB DREBs, NAC, bZIP, AP2/ERF, and AREB/ABF, which respond to drought by affecting stomatal movement or certain metabolic pathways [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic and Metabolomic Analysis of Seedling-Stage Soybean Responses to PEG-Simulated Drought Stress

Wang

Song

Wang

et al. 2022

IJMS

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Soybean is an important crop grown worldwide, and drought stress seriously affects the yield and quality of soybean. Therefore, it is necessary to elucidate the molecular mechanisms underlying soybean resistance to drought stress. In this study, RNA-seq technology and ultra-performance liquid chromatography–tandem mass spectrometry were used to analyze the transcriptome and metabolome changes in soybean leaves at the seedling stage under drought stress. The results showed that there were 4790 and 3483 DEGs (differentially expressed genes) and 156 and 124 DAMs (differentially expressed metabolites), respectively, in the HN65CK vs. HN65S0 and HN44CK vs. HN44S0 comparison groups. Comprehensive analysis of transcriptomic and metabolomic data reveals metabolic regulation of seedling soybean in response to drought stress. Some candidate genes such as LOC100802571, LOC100814585, LOC100777350 and LOC100787920, LOC100800547, and LOC100785313 showed different expression trends between the two cultivars, which may cause differences in drought resistance. Secondly, a large number of flavonoids were identified, and the expression of Monohydroxy-trimethoxyflavone-O-(6″-malonyl)glucoside was upregulated between the two varieties. Finally, several key candidate genes and metabolites involved in isoflavone biosynthesis and the TCA cycle were identified, suggesting that these metabolic pathways play important roles in soybean response to drought. Our study deepens the understanding of soybean drought resistance mechanisms and provides references for soybean drought resistance breeding.

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Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

Cited by 956 publications

References 130 publications

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Melatonin-Mediated Abiotic Stress Tolerance in Plants

Transcriptomic and Metabolomic Analysis of Seedling-Stage Soybean Responses to PEG-Simulated Drought Stress

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