Plant Food Extracts as Source of Bioactive Compounds for Prevention of Cisplatin-Induced Kidney Dysfunction in Rats

Al‐Okbi, Sahar Y.; Mohamed, Doha A.; Hamed, Thanaa E.; Esmail, Reham Sh.; Donya, Souria M.

doi:10.2478/v10222-012-0092-2

Cited by 9 publications

(5 citation statements)

References 45 publications

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“…This result agrees with that of Ekanem and Yusuf [57] . Kidney function parameters (Plasma urea and creatinine) were evoked due to some damage in liver and kidney within the tumor induced group relative to the normal control (Table 2) and this finding is in harmony with that of Al-Okbi et al [58] .…”

Section: A B C D E Fsupporting

confidence: 84%

Chemopreventive Effect of Hibiscus sabdariffa Calyx Anthocyanins and Nanoselenium against N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats

2015

Egyptian Journal of Pure and Applied Science

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Chemoprevention could play important role in the management of Hepatocellular carcinoma (HCC). HCC develop in pre-neoplastic organ, the cirrhotic liver. The study aimed at evaluating the efficacy of Hibiscus sabdariffa L. water extract containing anthocyanins and Nanoselenium (nSe) as chemo-protective substances on HCC induced by Diethylnitrosamine (DEN). Thioacetamide (TAA) which causes liver cirrhosis was used as initiator. The oxidative stress marker malondialdehyde (MDA) level for lipid peroxidation, liver antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) activities as well as reduced glutathione (GSH) content were measured, in addition, to Alpha fetoprotein (AFP), tumor necrosis factor (TNF-α) and caspase-3 levels. Treatment by H. sabdariffa extract significantly increase caspase-3 activity and decrease both TNF-α and AFP levels; significantly decrease the oxidative stress marker MDA level and increase the level of antioxidant markers SOD, CAT and GSH. The plant extract showed a remarkable effect as selenium which is known by its significant antioxidant effect. The findings were well depicted histopathologically. It can be concluded that HEx containing anthocyanin pigments and nSe can act strongly as chemo-protective substances against HCC, possibly by increasing apoptotic mechanism and antioxidant scavenger levels.

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Section: A B C D E Fsupporting

confidence: 84%

Chemopreventive Effect of Hibiscus sabdariffa Calyx Anthocyanins and Nanoselenium against N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats

2015

Egyptian Journal of Pure and Applied Science

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“…The elevated oxidative stress due to treatment with cispla¬tin might be the cause of chromosomal aberration and sperm shape abnormalities. Extract mixtures prepared from a polar and non-polar fraction of red grape, coriander, roselle, and fen¬nel were shown to be efficient in lowering chromosomal aberration and abnormal sperm induced by cisplatin [41].…”

Section: Methodsmentioning

confidence: 99%

Antimutagenic effect of grape seed extracted oil on diazinon induced genotoxicity in albino mice

Al-Attar¹

2018

IJCMG

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Background: Human health hazard due to exposure to chemical pollutants is a global and chronic problem. The pesticides constitute the primary toxic chemicals in the environment. The present study explored the effects of grape seed oil supplementation on diazinon (DZN) induced chromosomal aberrations and sperm abnormalities in male mice. Materials and methods: The tests were carried out on 35 adult male albino mice (16-20 weeks, weighed 30-35 g). Animals were categorized into seven groups each with five mice; the first group was treated with phos¬phate buffer saline (PBS) as negative control group. The second and third groups were treated daily and orally with two different doses of the DZN (60 and 90 mg/kg body weight) respectively dissolved in corn oil. Animals of fourth, fifth and sixth groups were orally administered grape seed oil at a dose of 2 g/kg body weight, after 6 hours the fourth and fifth groups subjected to DZN at the same dose given to second and third groups. Animals of the seventh group were supplied with corn oil. The treatments were continued for five weeks. Results: The results showed that DZN increased the frequency of both chromatid and chromosome aberrations in bone marrow cells and sperm abnormalities. Treatment with grape seed oil extract showed a significant decrease (P<0.01) on both total abnormal chromosomes and sperms, and there was no significant difference between these groups and negative control in most analyzed parameters. The dose of grape seed oil has significantly minimized the effect of first dose of DZN concerning chromosome structure while it worked in the second dose regarding sperm abnormalities. Conclusions: This finding suggests the protective action of grape seed oil against DZN induced clastogenecity and sperm abnormalities.

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“…110 Walnut can be added to bread to improve renal dysfunction; the results showed that bread rich in walnuts could reduce MDA, tumor necrosis factor-α, and low-density lipoprotein cholesterol content in plasma. 111 Additionally, the immunomodulatory effect of walnut oligopeptides (WOPs) was investigated by oral administration to female BALB/c mice at 110, 220, and 440 mg/kg BW for 30 consecutive days. The results showed that WOPs could significantly improve humoral and cell-mediated immune response, macrophage phagocytosis, and natural killer cell activity.…”

Section: Bioactivity Of Walnut Protein Hydrolysatesmentioning

confidence: 99%

“…Li et al found that WMH and dephenolized WMH could effectively reduce the serum uric acid level in rats with hyperuricemia induced by potassium oxalate, protect renal function, and inhibit xanthine oxidase . Walnut can be added to bread to improve renal dysfunction; the results showed that bread rich in walnuts could reduce MDA, tumor necrosis factor-α, and low-density lipoprotein cholesterol content in plasma . Additionally, the immunomodulatory effect of walnut oligopeptides (WOPs) was investigated by oral administration to female BALB/c mice at 110, 220, and 440 mg/kg BW for 30 consecutive days.…”

Section: Bioactivity Of Walnut Protein Hydrolysatesmentioning

confidence: 99%

Walnut Protein: A Rising Source of High-Quality Protein and Its Updated Comprehensive Review

Wen

Zhang

Cao

et al. 2023

J. Agric. Food Chem.

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Recently, plant protein as a necessary nutrient source for human beings, a common ingredient of traditional processed food, and an important element of new functional food has gained prominence due to the increasing demand for healthy food. Walnut protein (WP) is obtained from walnut kernels and walnut oil-pressing waste and has better nutritional, functional, and essential amino acids in comparison with other vegetable and grain proteins. WP can be conveniently obtained by various extraction techniques, including alkali-soluble acid precipitation, salting-out, and ultrasonic-assisted extraction, among others. The functional properties of WP can be modified for desired purposes by using some novel methods, including free radical oxidation, enzymatic modification, high hydrostatic pressure, etc. Moreover, walnut peptides play an important biological role both in vitro and in vivo. The main activities of the walnut peptides are antihypertensive, antioxidant, learning improvement, and anticancer, among others. Furthermore, WP could be applied in the development of functional foods or dietary supplements, such as delivery systems and food additives, among others. This review summarizes recent knowledge on the nutritional, functional, and bioactive peptide aspects of WP and possible future products, providing a theoretical reference for the utilization and development of oil crop waste.

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Plant Food Extracts as Source of Bioactive Compounds for Prevention of Cisplatin-Induced Kidney Dysfunction in Rats

Cited by 9 publications

References 45 publications

Chemopreventive Effect of Hibiscus sabdariffa Calyx Anthocyanins and Nanoselenium against N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats

Chemopreventive Effect of Hibiscus sabdariffa Calyx Anthocyanins and Nanoselenium against N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats

Antimutagenic effect of grape seed extracted oil on diazinon induced genotoxicity in albino mice

Walnut Protein: A Rising Source of High-Quality Protein and Its Updated Comprehensive Review

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