Plant lectin: A promising future anti-tumor drug

Konozy, Emadeldin Hassan E.; Osman, Mohamed

doi:10.1016/j.biochi.2022.08.002

Cited by 32 publications

(12 citation statements)

References 104 publications

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“…The aberrant glycosylation is usually reported in cancer cells and the profile of glycans can be used as a hallmark of cancer [ 93 ], and plant lectins are tools to identify the alteration in glycosylation [ 94 ]. In addition, the biological effects of the aberrant glycosylation are reflected in the signal transduction and cellular communication that favor the tumor cell invasion, tumor angiogenesis, and metastasis formation [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin’s Lymphoma Depends on Syk and Src Family Kinases

Barboza

Thomaz

Carvalho

et al. 2023

IJMS

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Receptors on the immune cell surface have a variety of glycans that may account for the immunomodulation induced by lectins, which have a carbohydrate recognition domain (CRD) that binds to monosaccharides or oligosaccharides in a specific manner. ArtinM, a D-mannose-binding lectin obtained from Artocarpus heterophyllus, has affinity for the N-glycans core. Immunomodulation by ArtinM toward the Th1 phenotype occurs via its interaction with TLR2/CD14 N-glycans on antigen-presenting cells, as well as recognition of CD3γ N-glycans on murine CD4+ and CD8+ T cells. ArtinM exerts a cytotoxic effect on Jurkat human leukemic T-cell line and human myeloid leukemia cell line (NB4). The current study evaluated the effects of ArtinM on murine and human B cells derived from non-Hodgkin’s lymphoma. We found that murine B cells are recognized by ArtinM via the CRD, and the ArtinM stimulus did not augment the proliferation rate or production of IL-2. However, murine B cell incubation with ArtinM augmented the rate of apoptosis, and this cytotoxic effect of ArtinM was also seen in human B cell-lines sourced from non-Hodgkin’s lymphoma Raji cell line. This cytotoxic effect was inhibited by the phosphatase activity of CD45 on Lck, and the protein kinases of the Src family contribute to cell death triggered by ArtinM.

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Section: Discussionmentioning

confidence: 99%

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin’s Lymphoma Depends on Syk and Src Family Kinases

Barboza

Thomaz

Carvalho

et al. 2023

IJMS

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“…There are relevant references available for the reader which provide in-depth details and summaries of amounts of active lectins, in commonly consumed foods, like wheat and wheat-derived products ( 10 , 11 , 22 ). For a comprehensive updated review on plant lectins and their promising futuristic anti-tumor effect, see the work of Konozy and Osman ( 23 ).…”

Section: Methodsmentioning

confidence: 99%

Anti(angiogenic) food components: can be a major source of bias in the investigation of angiogenesis inhibitors

Rastmanesh,

Bowirrat,

Gupta

et al. 2023

Ann Transl Med

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Background Natural and diet-derived angiogenesis inhibitors/promotors are widely found in diets. These compounds can in several ways impact the results of oncological research of angiogenesis inhibitors. Methods We very briefly overview some of the most important examples to show how these compounds can create a bias in current research of cancer. Implications of this expert opinion cover similar angiogenesis-related diseases. Results Significant intra-individual differences in terms of dietary intake and differential effect of food processing techniques result in differential bioactivity and bioavailability of these compounds. There are only a handful of validated dietary questionnaire to quantify natural angiogenesis inhibitors/promotors. A corollary consequence is that participants in non-randomized clinical trials will have different baseline levels of serum/plasma/tissue/organ diet-derived angiogenesis inhibitors/promotors. This will lead to creation of clinical uncertainty and a hidden bias and consequently creation of translational efficiency bias, sampling efficiency, and waste of resources. We call for developing and validating a semi-quantitative food frequency questionnaire (FFQ) to gather data on these agents, specifically designed for oncological research because there is a clear gap in the literature of oncology. Conclusions This might facilitate the discovery of better prognostic, diagnostic, preventive measures, and therapeutic agents for the management of different cancers. Implications of this paper cover similar settings like ophthalmologic research.

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“…Due to carbohydrate specificity, lectins display applications in various fields, including glycobiology, immunohistochemical analysis, diagnosis, therapeutics, drug delivery, etc. Indeed, multiple lectins showed anticancer and antimicrobial activity [ 80 , 81 ]. The human erythrocytes agglutinating property has been considered a serious concern in developing lectin-based therapy.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Lectins as the prominent potential to deliver bioactive metal nanoparticles by recognizing cell surface glycans

Bala Subramaniyan,

Veerappan

2024

Heliyon

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Plant lectin: A promising future anti-tumor drug

Cited by 32 publications

References 104 publications

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin’s Lymphoma Depends on Syk and Src Family Kinases

ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin’s Lymphoma Depends on Syk and Src Family Kinases

Anti(angiogenic) food components: can be a major source of bias in the investigation of angiogenesis inhibitors

Lectins as the prominent potential to deliver bioactive metal nanoparticles by recognizing cell surface glycans

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