Plant Phenolic Compounds as Potential Lead Compounds in Functional Foods for Antiviral Drug Discovery

Li, Wan Fei; Chik, Wai I.; Wang, Dongying; Pan, Lu-Tai

doi:10.2174/1385272821666170207160128

Cited by 5 publications

(8 citation statements)

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“…Multiple reviews have also focused on the effect of tea catechins concentrated in green tea and the oxidized tea flavins from black tea on antiviral and anti-inflammatory activities ( 117–119 ). The mechanism and characteristics of phenolic compounds to fight viral infections and their potential to be used as emerging therapeutic drugs have been reviewed ( 120 , 121 ) and compared with commonly used antivirals ( 16 , 55 ). Although phenolic compounds trigger the immune response, either by reducing ROS, activating enzymatic responses, or inactivating pathogens, the mechanism of absorption and the mode of action in human plasma remains unclear ( 21 ).…”

Section: Oxidative Stress In Viral Infections and The Role Of Dietarymentioning

confidence: 99%

Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance During the SARS-CoV-2/COVID-19 Pandemic

Trujillo-Mayol

Guerra‐Valle

Casas-Forero

et al. 2021

Advances in Nutrition

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The importance of balanced dietary habits, which include appropriate amounts of antioxidants to maintain the immune system, has become increasingly relevant during the current SARS-CoV-2/COVID-19 pandemic, because viral infections are characterized by high oxidative stress. Furthermore, the measures taken by governments to control the pandemic have led to increased anxiety, stress, and depression, which affect physical and mental health, all of which are influenced by nutritional status, diet, and lifestyle. The Mediterranean diet (MD), Atlantic diet (AD), and the Dietary Guidelines for Americans all provide the essential vitamins, minerals, and phenolic compounds needed to activate enzymatic and nonenzymatic antioxidant responses. However, viral pandemics such as the current COVID-19 crisis entail high oxidative damage caused by both the infection and the resultant social stresses within populations, which increases the probability and severity of infection. Balanced dietary patterns such as the MD and the AD are characterized by the consumption of fruit, vegetables, legumes, olive oil, and whole grains with low intakes of processed foods and red meat. For a healthy lifestyle in young adults, the MD in particular provides the required amount of antioxidants per day for vitamins D (0.3–3.8 μg), E (17.0 mg), C (137.2–269.8 mg), A (1273.3 μg), B-12 (1.5–2.0 μg), and folate (455.1–561.3 μg), the minerals Se (120.0 μg), Zn (11.0 mg), Fe (15.0–18.8 mg), and Mn (5.2–12.5 mg), and polyphenols (1171.00 mg) needed to maintain an active immune response. However, all of these diets are deficient in the recommended amount of vitamin D (20 μg/d). Therefore, vulnerable populations such as elders and obese individuals could benefit from antioxidant supplementation to improve their antioxidant response. Although evidence remains scarce, there is some indication that a healthy diet, along with supplemental antioxidant intake, is beneficial to COVID-19 patients.

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Section: Oxidative Stress In Viral Infections and The Role Of Dietarymentioning

confidence: 99%

Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance During the SARS-CoV-2/COVID-19 Pandemic

Trujillo-Mayol

Guerra‐Valle

Casas-Forero

et al. 2021

Advances in Nutrition

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“…Natural products are inexhaustible source of drug discovery which always offers not only new compounds with interesting structures and different entities but also very important intermediates like shikimic acid which originated from Illicium verum fruits which serve as a source for synthesis and commercial production oseltamivir as an effective treatment for avian influenza virus H5N1, seasonal influenza virus types A and B and human influenza virus H1N1 of swine origin [4,5]. Phenolic compounds and their derivatives are widely distributed in nature especially from plants, their diverse structures and combinations which may be founded as acids or esters or amides and also may including nitrogen in monomer or dimmer structures or even more [6]. Tens of phenolic compounds of different classes (phenolic acids, flavonoids and coumarins) are showing potent activities against many viruses like herpes simplex (HSV), influenza, epstein-barr hepatitis B and human immunodeficiency viruses (HIV) through different mechanisms [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Phenolic compounds and their derivatives are widely distributed in nature especially from plants, their diverse structures and combinations which may be founded as acids or esters or amides and also may including nitrogen in monomer or dimmer structures or even more [6]. Tens of phenolic compounds of different classes (phenolic acids, flavonoids and coumarins) are showing potent activities against many viruses like herpes simplex (HSV), influenza, epstein-barr hepatitis B and human immunodeficiency viruses (HIV) through different mechanisms [6,7]. Antiviral activity and structure diversity and complexity of phenolic acids like caffeic acid derivatives as a major compounds of this study make them a suitable candidates for exploring their activity against COVID-19 [8].…”

Section: Introductionmentioning

confidence: 99%

“…The structure activity relationship revealed that n-alkyl side chain and catechol moiety are a pharmacophore responsible for the anti HCV activities [8,9]. Chicoric acid or dicaffeoyltartaric acid is dimeric caffeic acid derivative with tartaric acid which also showed more potent antiviral activity against HIV [6]. Amide group is founded to increase antiviral activity of coumarin-based inhibitors against HIV through increasing biding affinity due hydrogen bonding [10].…”

Section: Introductionmentioning

confidence: 99%

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Hordatines as a Potential Inhibitor of COVID-19 Main Protease and RNA Polymerase: An In-Silico Approach

Dahab

Hegazy

Abbass

2020

Nat. Prod. Bioprospect.

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Total 40 natural compounds were selected to perform the molecular docking studies to screen and identify the potent antiviral agents specifically for Severe Acute Respiratory Syndrome Coronavirus 2 that causes coronavirus disease 2019 (COVID-19). The key targets of COVID-19, protease (PDB ID: 7BQY) and RNA polymerase (PDB ID: 7bV2) were used to dock our target compounds by Molecular Operating Environment (MOE) version 2014.09. We used 3 different conformations of protease target (6M0K, 6Y2F and 7BQY) and two different score functions to strengthen the probability of inhibitors discovery. After an extensive screening analysis, 20 compounds exhibit good binding affinities to one or both COVID-19 targets. 7 out of 20 compounds were predicted to overcome the activity of both targets. The top 7 hits are, flacourticin (3), sagerinic acid (16), hordatine A (23), hordatine B (24), N-feruloyl tyramine dimer (25), bisavenanthramides B-5 (29) and vulnibactins (40). According to our results, all these top hits was found to have a better binding scores than remdesivir, the native ligand in RNA polymerase target (PDB ID: 7bV2). Hordatines are phenolic compounds present in barley, were found to exhibit the highest binding affinity to both protease and polymerase through forming strong hydrogen bonds with the catalytic residues, as well as significant interactions with other receptor-binding residues. These results probably provided an excellent lead candidate for the development of therapeutic drugs against COVID-19. Eventually, animal experiment and accurate clinical trials are needed to confirm the preventive potentials of these compounds. Graphic Abstract

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“…Natural products are inexhaustible source of drug discovery which always offers not only new compounds with interesting structures and different entities but also very important intermediates like Shikimic acid which originated from Illicium verum fruits which serve as a source for synthesis and commercial production Oseltamivir as an effective treatment for avian in uenza virus H5N1, seasonal in uenza virus types A and B and human in uenza virus H1N1 of swine origin. [4,5] Phenolic compounds and their derivatives are widely distributed in nature especially from plants, their diverse structures and combinations which may be founded as acids or esters or amides and also may including nitrogen in monomer or dimmer structures or even more. [6] Tens of phenolic compounds of different classes (phenolic acids, avonoids and coumarins) are showing potent activities against many viruses like Herpes simplex (HSV), In uenza, Epstein-Barr Hepatitis B and Human Immunode ciency (HIV) viruses through different mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Hordatines as a Potential Inhibitor of COVID-19 Main Protease and RNA Polymerase: An In-Silico Approach

Mostafa¹,

Mohammed²,

Hatem³

2020

Preprint

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Total 40 natural compounds were selected to perform the molecular docking studies to screen and identify the potent antiviral agents specifically for Severe Acute Respiratory Syndrome Coronavirus 2 that causes coronavirus disease 2019 (COVID-19). The key targets of COVID-19, protease (PDB ID: 6M0K, 6Y2F and 7BQY) and RNA polymerase (PDB ID: 7bV2) were used to dock our target compounds by Molecular Operating Environment (MOE) version 2014.09. After an extensive screening analysis, 20 compounds exhibit good binding affinities to one or more of the COVID-19 targets. 7 out of 20 compounds were predicted to overcome the activity of the 4 drug targets. The top 7 hits are compounds; Flacourticin (3), Sagerinic acid (16), Hordatine A (23), Hordatine B (24), N-feruloyl tyramine dimer (25), Bisavenanthramides B-5 (29) and Vulnibactins (40). According to our results, all these top hits was found to have a better binding scores than Remdesivir, the native ligand in RNA polymerase target (PDB ID: 7bV2). Hordatines are phenolic compounds present in barley, were found to exhibit the highest binding affinity to both protease and polymerase through forming strong hydrogen bonds with the catalytic residues, as well as significant interactions with other receptor-binding residues. These results probably provided an excellent lead candidate for the development of therapeutic drugs against COVID-19. Eventually, animal experiment and accurate clinical trials are needed to confirm the preventive potentials of these compounds.

show abstract

Plant Phenolic Compounds as Potential Lead Compounds in Functional Foods for Antiviral Drug Discovery

Cited by 5 publications

References 0 publications

Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance During the SARS-CoV-2/COVID-19 Pandemic

Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance During the SARS-CoV-2/COVID-19 Pandemic

Hordatines as a Potential Inhibitor of COVID-19 Main Protease and RNA Polymerase: An In-Silico Approach

Hordatines as a Potential Inhibitor of COVID-19 Main Protease and RNA Polymerase: An In-Silico Approach

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