Plant Polysaccharides in Engineered Pharmaceutical Gels

Bahú, Juliana O.; Andrade, Lucas Rannier Melo de; Barbosa, Raquel de Melo; Crivellin, Sara; Silva, Aline Pioli da; Souza, Samuel D. A.; Concha, Víktor Oswaldo Cárdenas; Severino, Patrícia; Souto, Eliana B.

doi:10.3390/bioengineering9080376

Cited by 19 publications

(10 citation statements)

References 179 publications

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“…29 In contrast to non-biodegradable hydrogels, polysaccharide based hydrogels are preferred for agricultural applications owing to their biodegradable nature. Among polysaccharides, F I G U R E 3 Hydrogels obtained from natural sources and their applications adopted with permission from Bahú et al 33 chitosan elicit and boost defense system of plants. 30 It is also reported that bean treatment along with chitosan inhibited necrosis caused by mosaic virus.…”

Section: Biopolymersmentioning

confidence: 99%

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Eco‐friendly three‐dimensional hydrogels for sustainable agricultural applications: Current and future scenarios

Azeem

Islam

Khan

et al. 2023

Polymers for Advanced Techs

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Modern world is searching for water efficient agriculture techniques as irrigation is becoming scarce. Limited water resources and more food demand are the two key challenges in agriculture. Hydrogels which can respond intelligently by pH, temperature, light, ionic strength, osmotic pressure, magnetic or electric field changes are termed as intelligent or smart hydrogels which are analogous to conventional hydrogels in preparatory methods and features. Lag phase, constant release and decay phase are three steps involved in release of nutrients from polymeric hydrogels. In fact, hydrogels act as little reservoirs of water and dissolve nutrients that are released in controlled manner anchored by plant roots via capillary action. Hydrogels also sustain optimum amount of water in water stress conditions and reabsorb water in moist conditions which ultimately increases seedling, seed germination, plant growth and crop yield. Fertilizer and salt release are majorly dependent upon pH and temperature followed by diffusion‐controlled mechanism. Cross‐linkers, binders and fillers play pivotal role in determining properties, architecture and hydrogel pores. In comparison to potassium (K+) and phosphate (PO4−3) ions, nitrates (NO3−1) and ammonium (NH4+1) ions exhibited faster release rate. This review spotlights application prospects of three dimensional hydrogel in agriculture. Initially, properties of hydrogels, their classification, preparatory methods, effect of natural‐synthetic‐polymer blending and role of fillers are stated. Afterward, hydrogel functioning, significance, advantages, mechanism of fertilizer release and agriculture specific applications of hydrogels are comprehensively described. In conclusion, extraordinary biocompatible, cheaper, stable, biodegradable, durable, non‐toxic and re‐wettable characteristics of hydrogel systems motivated their utilization in agronomical applications.

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Section: Biopolymersmentioning

confidence: 99%

“…Hydrogels obtained from natural sources and their applications adopted with permission from Bahú et al 33 …”

Section: Introductionmentioning

confidence: 99%

Eco‐friendly three‐dimensional hydrogels for sustainable agricultural applications: Current and future scenarios

Azeem

Islam

Khan

et al. 2023

Polymers for Advanced Techs

View full text Add to dashboard Cite

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“…Therefore, the range of polymers used for the manufacture of hydrogels is limited. These include natural and synthetic polymers, in particular, poly-N-vinylpyrrolidone [ 36 ], polyoxazolines and copolymers of oxazolines [ 37 , 38 , 39 ], polysaccharides [ 40 ], polyurethanes [ 41 ], poly-N-isopropylacrylamide [ 42 ], polyacrylic acid [ 43 ] and others.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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“…But sugar beet pectin has a lower molecular weight and a larger number of acetyl groups, so the gelling ability is lower. Special conditions are required for the gelation of HM pectins [11]:…”

Section: Introductionmentioning

confidence: 99%

Overview of the Pharmacological Use of Pectins and Pectin-Containing Substances: Recent Achievements and Prospects

Maslova¹,

Mishvelov²,

Nasrulaeva³

et al. 2023

Pharmacophore

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Biomedical and pharmaceutical properties of pectinThis paper is an overview on the Pectins which are a group of polysaccharides from plant cells. Structural diversity makes functionality of the pectins versatile with a variety of biological, technofunctional, biomedical, and pharmaceutical properties. Nearly all the plants contain pectin, however, the majority of it is used commercially and is derived from citrus fruits, specifically oranges, lemons, grapefruit, and apples. Commercial production is judged on new features and applications in addition to economics. Recently, there has been an effort to find new sources of pectin, such as using the leftovers from the processing of pulp from sugar beet, mango, and sunflower. Pectin substances can affect the human body as follows: prebiotic effect, cholesterol reduction, anti-inflammatory and antimicrobial effect, antitumor effect, biosorbent, transportation of drugs. This article's goal is to discuss pectin application techniques and pectin-containing products. The prospects of further development and use of these biopolymers are also considered.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Plant Polysaccharides in Engineered Pharmaceutical Gels

Cited by 19 publications

References 179 publications

Eco‐friendly three‐dimensional hydrogels for sustainable agricultural applications: Current and future scenarios

Eco‐friendly three‐dimensional hydrogels for sustainable agricultural applications: Current and future scenarios

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Overview of the Pharmacological Use of Pectins and Pectin-Containing Substances: Recent Achievements and Prospects

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