Plant Raf-like kinases regulate the mRNA population upstream of ABA-unresponsive SnRK2 kinases under drought stress

Soma, Fumiyuki; Takahashi, Fumiyuki; Suzuki, Takamasa; Shinozaki, Kazuo; Yamaguchi-Shinozaki, Kazuko

doi:10.1038/s41467-020-15239-3

Cited by 135 publications

(170 citation statements)

References 51 publications

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“…ABA also enables the activation of guard cell membrane-localized transporters through phosphorylation mediated by calcium dependent kinases (CDPKs) and other kinases, indicating alternative stomatal regulatory pathways independent of SnRK2s (Cai et al, 2017;Pornsiriwong et al, 2017). Most recently, subgroup B Raf-like kinases have been identified as upstream regulators of SnRK2s for ABA signal transduction and response to osmotic and drought stresses in Arabidopsis (Saruhashi et al, 2015;Katsuta et al, 2020;Lin et al, 2020;Soma et al, 2020;Takahashi et al, 2020). Furthermore, it's revealed that this regulatory module is evolutionarily conserved in land plants, at least for conferring protection against drought (Katsuta et al, 2020).…”

Section: Overview Of Aba Signaling Networkmentioning

confidence: 99%

Evolution of Abscisic Acid Signaling for Stress Responses to Toxic Metals and Metalloids

Deng

Chen

et al. 2020

Front. Plant Sci.

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Toxic heavy metals and metalloids in agricultural ecosystems are crucial factors that limit global crop productivity and food safety. Industrial toxic heavy metals and metalloids such as cadmium, lead, and arsenic have contaminated large areas of arable land in the world and their accumulation in the edible parts of crops is causing serious health risks to humans and animals. Plants have co-evolved with various concentrations of these toxic metals and metalloids in soil and water. Some green plant species have significant innovations in key genes for the adaptation of abiotic stress tolerance pathways that are able to tolerate heavy metals and metalloids. Increasing evidence has demonstrated that phytohormone abscisic acid (ABA) plays a vital role in the alleviation of heavy metal and metalloid stresses in plants. Here, we trace the evolutionary origins of the key gene families connecting ABA signaling with tolerance to heavy metals and metalloids in green plants. We also summarize the molecular and physiological aspects of ABA in the uptake, rootto-shoot translocation, chelation, sequestration, reutilization, and accumulation of key heavy metals and metalloids in plants. The molecular evolution and interaction between the ABA signaling pathway and mechanisms for heavy metal and metalloid tolerance are highlighted in this review. Therefore, we propose that it is promising to manipulate ABA signaling in plant tissues to reduce the uptake and accumulation of toxic heavy metals and metalloids in crops through the application of ABA-producing bacteria or ABA analogues. This may lead to improvements in tolerance of major crops to heavy metals and metalloids.

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Section: Overview Of Aba Signaling Networkmentioning

confidence: 99%

Evolution of Abscisic Acid Signaling for Stress Responses to Toxic Metals and Metalloids

Deng

Chen

et al. 2020

Front. Plant Sci.

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“…Both the positive and the negative regulatory proteins of the SnRK2 kinase are, too, conserved throughout land plant evolution ( Lind et al, 2015 ; Saruhashi et al, 2015 ; Yasumura et al, 2015 ; Stevenson et al, 2016 ; Lin et al, 2020 ; Takahashi et al, 2020 ). Post-translational modifications and protein–protein interactions are the two key regulation means of SnRK2 ( Belin et al, 2006 ; Vlad et al, 2009 ; Soon et al, 2012 ; Saruhashi et al, 2015 ; Stevenson et al, 2016 ; Nguyen et al, 2019 ; Lin et al, 2020 ; Soma et al, 2020 ; Takahashi et al, 2020 ). The activation of Arabidopsis SnRK2s requires phosphorylation of key serine residues in kinase activation loop (Ser171 and Ser175 for AtSnRK2.6/OST1; Vlad et al, 2010 ; Soon et al, 2012 ).…”

Section: The Pp2c-snrk2 Signaling Module Throughout Plant Evolutionmentioning

confidence: 99%

Evolution of Abscisic Acid Signaling Module and Its Perception

et al. 2020

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We hereby review the perception and responses to the stress hormone Abscisic acid (ABA), along the trajectory of 500M years of plant evolution, whose understanding may resolve how plants acquired this signaling pathway essential for the colonization of land. ABA levels rise in response to abiotic stresses, coordinating physiological and metabolic responses, helping plants survive stressful environments. In land plants, ABA signaling cascade leads to growth arrest and large-scale changes in transcript levels, required for coping with environmental stressors. This response is regulated by a PYRABACTIN RESISTANCE 1-like (PYL)-PROTEIN PHOSPHATASE 2C (PP2C)-SNF1-RELATED PROTEIN KINASE 2 (SnRK2) module, that initiates phosphor-activation of transcription factors and ion channels. The enzymatic portions of this module (phosphatase and kinase) are functionally conserved from streptophyte algae to angiosperms, whereas the regulatory component-the PYL receptors, putatively evolved in the common ancestor of Zygnematophyceae and embryophyte as a constitutive, ABA-independent protein, further evolving into a ligand-activated receptor at the embryophyta. This evolutionary process peaked with the appearance of the strictly ABA-dependent subfamily III stress-triggered angiosperms' dimeric PYL receptors. The emerging picture is that the ancestor of land plants and its predecessors synthesized ABA, as its biosynthetic pathway is conserved between ancestral and current day algae. Despite this ability, it was only the common ancestor of land plants which acquired the hormonal-modulation of PYL activity by ABA. This raises several questions regarding both ABA's function in ABA-non-responsive organisms, and the evolutionary aspects of the ABA signal transduction pathway.

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“…The core ABA signaling pathway has been reconstituted successfully with those key components in vitro [ 35 ]. Interestingly, several recent studies simultaneously showed that Raf-like kinases (RAFs) could quickly activate SnRK2s to respond to ABA, osmotic and drought stress by direct phosphorylation [ 36 , 37 , 38 , 39 ].…”

Section: Mediator Complex As a Pivotal Regulator Of Aba Signaling mentioning

confidence: 99%

Mediator Complex: A Pivotal Regulator of ABA Signaling Pathway and Abiotic Stress Response in Plants

Chong

Guo

Zhu

2020

IJMS

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As an evolutionarily conserved multi-protein complex, the Mediator complex modulates the association between transcription factors and RNA polymerase II to precisely regulate gene transcription. Although numerous studies have shown the diverse functions of Mediator complex in plant development, flowering, hormone signaling, and biotic stress response, its roles in the Abscisic acid (ABA) signaling pathway and abiotic stress response remain largely unclear. It has been recognized that the phytohormone, ABA, plays a predominant role in regulating plant adaption to various abiotic stresses as ABA can trigger extensive changes in the transcriptome to help the plants respond to environmental stimuli. Over the past decade, the Mediator complex has been revealed to play key roles in not only regulating the ABA signaling transduction but also in the abiotic stress responses. In this review, we will summarize current knowledge of the Mediator complex in regulating the plants’ response to ABA as well as to the abiotic stresses of cold, drought and high salinity. We will particularly emphasize the involvement of multi-functional subunits of MED25, MED18, MED16, and CDK8 in response to ABA and environmental perturbation. Additionally, we will discuss potential research directions available for further deciphering the role of Mediator complex in regulating ABA and other abiotic stress responses.

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Plant Raf-like kinases regulate the mRNA population upstream of ABA-unresponsive SnRK2 kinases under drought stress

Cited by 135 publications

References 51 publications

Evolution of Abscisic Acid Signaling for Stress Responses to Toxic Metals and Metalloids

Evolution of Abscisic Acid Signaling for Stress Responses to Toxic Metals and Metalloids

Evolution of Abscisic Acid Signaling Module and Its Perception

Mediator Complex: A Pivotal Regulator of ABA Signaling Pathway and Abiotic Stress Response in Plants

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