Plant virus nanoparticles: Novel and robust nanocarriers for drug delivery and imaging

Alemzadeh, Effat; Dehshahri, Ali; Izadpanah, K.; Ahmadi, Fatemeh

doi:10.1016/j.colsurfb.2018.03.026

Cited by 57 publications

(30 citation statements)

References 69 publications

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“…The characteristic three dimensional structures of dendrimers enable them to pass through cell membranes; therefore, they are better nano delivery materials than the classical polymers [96]. Due to these unique properties, cationic dendrimers have been widely used for drug and gene delivery [97][98][99]. However, to date, there is no report regarding whether dendrimers can deliver a DNA vaccine in the field of veterinary vaccines.…”

Section: Dendrimersmentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

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Polymer-based nanoparticles have good solubility, stability, safety, and sustained release,which increases the absorption of loaded drugs, protects the drugs from degradation, and prolongs their circulation time and targeted delivery. Generally, we believe that prevention and control of infectious diseases through inoculation is the most efficient measure. However, these vaccines including live attenuated vaccines, inactivated vaccines, protein subunit vaccines, recombinant subunit vaccines, synthetic peptide vaccines and DNA vaccines have several defects, such as immune tolerance, poor immunogenicity, low expression level and induction of respiration pathological changes. All kinds of biodegradable natural and synthetic polymers play major roles in the vaccine delivery system to control the release of antigens for an extended period of time. In addition, these polymers also serve as adjuvants to enhance the immunogenicity of vaccine. This review mainly introduces natural and synthetic polymer-based nanoparticles and their formulation and properties. Moreover, polymer-based nanoparticles as adjuvants and delivery carriers in the applications of vaccine are also discussed. This review provides the basis for further operation of nano vaccines by utilizing the polymer-based nanoparticles as vaccine adjuvants and delivery systems. Polymer-based nanoparticles have exhibited great potential in improving the immunogenicity of antigens and the development of nano vaccines in future.

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Section: Dendrimersmentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

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“…VLPs have been investigated as nanocarriers of a number of clinically approved and experimental chemotherapeutic agents. [ 10,130,131 ] The conjugation or complexation of a therapeutic compound with VLPs can have several advantages, including the improvement of its pharmacokinetics, its optimal biodistribution, and enhanced drug delivery to diseased sites while avoiding off‐target effects. Protein engineering can also control the surface charge on the viral capsid, drug encapsulation, particle stability, and ligand display.…”

Section: Biomedical Applications Of Vlpsmentioning

confidence: 99%

“…VLPs can be used to deliver not only DOX but also other anticancer drugs, including paclitaxel (PTX), mitoxantrone (MTO), and phenanthriplatin (PhenPt). [ 2,10,130 ] Niikura et al. synthesized VLPs coupled to cyclodextrins (CDs) via disulfide bonds, which acted as hydrophobic vesicles and incorporated hydrophobic drugs.…”

Section: Biomedical Applications Of Vlpsmentioning

confidence: 99%

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Virus‐Like Particles as Theranostic Platforms

Sun

Cui

2020

Advanced Therapeutics

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In recent years, theranostics have received enormous attention for their use in individualized diagnosis and treatment. The ability of viral coat protein subunits to assemble hierarchically can be used to package various kinds of foreign compounds. Moreover, numerous chemistries and modification strategies allow the functionalization of these virus-like particles (VLPs) with imaging reagents, targeting ligands, or therapeutic molecules. VLP nanoplatforms have great potential utility in the design of sophisticated multifunctional theranostic platforms. Numerous studies have reported the construction of multifunctional nanoparticles using VLPs for targeted diagnoses and treatment. In this paper, the latest progress in molecular imaging, drug delivery, and multifunctional theranostic nanodevices based on VLPs is reviewed.

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“…To this end, we turned toward the development of plant virus‐based nanoparticles (VNPs) for the delivery of PS. VNPs have been developed as carriers for the delivery of contrast agents, chemotherapeutics, protein therapies, epitopes, agro‐pesticides, as well as PS . Plant VNPs have several attributes that are favorable for nanomedicine delivery and in particular PS delivery.…”

mentioning

confidence: 99%

Let There Be Light: Targeted Photodynamic Therapy Using High Aspect Ratio Plant Viral Nanoparticles

Chariou

Wang

Desai

et al. 2019

Macromolecular Bioscience

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The development of plant viral nanoparticles (VNP) loaded with different molecular versions of a photodynamic drug is described. Specifically, tobacco mosaic virus (TMV) and tobacco mild green mosaic virus (TMGMV) are developed as drug carriers that encapsulate the monocationic, dicationic, tricationic, and tetracationic versions of a porphyrin‐based photosensitizer drug (Zn‐Por). While TMV has been extensively explored for various nanotechnology applications, this is the first study investigating TMGMV for medical applications. Light‐activated cancer cell killing of Zn‐Por‐loaded VNPs is studied in vitro using melanoma and cervical cancer models. Native and nucleolin‐targeted VNP drug carriers are developed and their efficacy assessed. A fivefold increase in cancer cell killing is observed using nucleolin‐targeted TMV loaded with tricationic Zn‐Por and displaying the nucleolin‐specific F3 peptide.

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Plant virus nanoparticles: Novel and robust nanocarriers for drug delivery and imaging

Cited by 57 publications

References 69 publications

Applications of polymer-based nanoparticles in vaccine field

Applications of polymer-based nanoparticles in vaccine field

Virus‐Like Particles as Theranostic Platforms

Let There Be Light: Targeted Photodynamic Therapy Using High Aspect Ratio Plant Viral Nanoparticles

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