Plants traditionally used individually and in combination to treat sexually transmitted infections in northern Maputaland, South Africa: Antimicrobial activity and cytotoxicity

Naidoo, Dinesh; Vuuren, Sandy van; Zyl, Robyn L. van; Wet, H. de

doi:10.1016/j.jep.2013.07.018

Cited by 74 publications

(58 citation statements)

References 126 publications

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“…The authors concluded that hydroalcoholic extract of A. officinalis L. can be useful alone or with other antibacterial factors for treatment of some of the bacterial infections and studying its constituents is required to determine the antimicrobial specific molecule because of their redox properties" [10]. A study showed that E. hypericifolia exhibited moderate antimicrobial activity [11].…”

Section: Discussionmentioning

confidence: 99%

“…38 were excluded from the study because of different reasons [ Figure 1]. 44 patients were randomly allocated Muhallil [8] Plant-used in colic, diarrhea and dysentery [13] antimicrobial [11] The plant contains taraxerol, octacosanol, campesterol, stigmasterol, beta-sitosterol, quercetin, quercitrin, ellagic acid, rhamnetin-3-galactoside, rhmnetin-3-rhamnoside and kaempfero […”

Section: Participants Flowmentioning

confidence: 99%

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A comparative study of polyherbal Unani formulations in gestational Urinary tract infections

Nishat¹,

Sultana²,

Sultana³

2017

J Exp Integr Med

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Introduction:To compare the efficacy of two polyherbal Unani formulations in gestational urinary tract infections (GUTIs). Materials and Methods: A prospective, randomized, comparative trial was conducted at Nizamia Tibbia College. Group A (n = 20) received mucilage of Althaea officinalis L. (5 ml) with 2.5 g powder of Sphaeranthus indicus L., Euphorbia hypericifolia L., Tribulus terrestris L., and Sharbat Anar shireen (Punica granatum) 10 ml, whereas Group B (n = 20) received 2.5 g powder of Citrullus vulgaris seeds L., Cucumis melo L. seed, and S. indicus L. orally twice daily after meals for 3 consecutive months. The primary outcome included cured measured as negative urine culture and alleviation of GUTIs symptoms. The secondary outcomes included the absence of pus cell in urine analysis, Apgar score, prevention of complication of GUTIs, and perinatal outcome. The results were analyzed with chi-square, Fisher exact test and student t-test with alpha 0.05. Results: The cure rate in Groups A and B was similar with 50% response. Both groups were equally effective in relieving the GUTIs symptoms (P < 0.001), Apgar score was >7, good perinatal outcome with no preterm labor, and intrauterine growth retardation. No maternal and fetal adverse effects were noted. Conclusion: Both groups were equally effective for the treatment of GUTIs without any maternal and fetal adverse effects.

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Section: Discussionmentioning

confidence: 99%

Section: Participants Flowmentioning

confidence: 99%

A comparative study of polyherbal Unani formulations in gestational Urinary tract infections

Nishat¹,

Sultana²,

Sultana³

2017

J Exp Integr Med

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“…Trichomonas and Giardia were first grown in microtiter plate at 37°C for 24 h and then added into 96-well U-bottom plates (Greiner). After 48 h, the viability of parasites was assayed colorimetrically by the mitochondrial oxidation of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay as was previously described in the literature with some modifications [29,40]. Briefly, MTT was dissolved in PBS (5 mg/cm 3 ) and sterilized by filtration (0.22 lm).…”

Section: Susceptibility Assaymentioning

confidence: 99%

The synthesis of novel hybrid compounds containing 5-nitrothiazole moiety as potential antiparasitic agents

Saleh

Saadeh

Kaur³

et al. 2015

Monatsh Chem

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A number of novel compounds containing 5-nitrothiazole moiety as potential antiparasitic agents have been synthesized through known chemical routes. The structures of the new compounds were confirmed by spectroscopic techniques, 1 H NMR, 13 C NMR, and mass spectrometry, and by elemental analyses. The prepared compounds were evaluated in vitro for their antigiardial and antitrichomonal activities. All tested compounds exhibited remarkable antigiardial activity with IC 50 values ranging from 2.2 to 6.9 lg/cm 3 as compared to the reference drug metronidazole (IC 50 = 7.3 lg/cm 3 ). In addition, three of the prepared compounds exhibited significant antitrichomonal activity with IC 50 values of 4.3, 5.0, and 7.9 lg/cm 3 , respectively, as compared to the reference drug metronidazole (8.5 lg/cm 3 ). Graphical abstract

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“…In vitro anti-parasitic activity [26]: the purified compounds and standard drug metronidazole were initially dissolved in dimethyl sulfoxide (DMSO; Sigma, USA). Trichomonads and Giardia were first grown in microtiter plate at 37°C for 24 h and then added to antimicrobial agents with serial two-fold dilutions (0.9-15 lg/cm 3 ) in 96-well U-bottom plates (Greiner).…”

Section: Susceptibility Assaymentioning

confidence: 99%

“…All experiments were run in triplicates to examine the anti-parasitic activity of the investigated compounds. After 48 h, the viability of parasites was assayed colorimetrically by the mitochondrial oxidation of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) as described previously with minor modifications [26]. Briefly, MTT was dissolved in PBS (5 mg/cm 3 ) and sterilized by filtration (0.22 lm).…”

Section: Susceptibility Assaymentioning

confidence: 99%

Synthesis, characterization, and biological activity of novel metronidazole-piperazine amides

et al. 2014

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A new series of metronidazole derivatives containing piperazine rings were prepared via the reaction of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetyl chloride with selected substituted piperazines in the presence of a base. Structures of the new compounds were confirmed by NMR and MS spectral data and by elemental analyses. The antibacterial and anti-parasitic activities of these compounds were evaluated in vitro. Some of the newly synthesized compounds exhibited superior activity against Clostridium sporogenes bacteria compared to the standard drug metronidazole. On the other hand, other derivatives exhibited remarkable antigiardial activity and were found to be more active than metronidazole with IC 50 ranging from 1.8 to 6.7 lg/dm 3 . 1-Ethyl-4-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]piperazine also exhibited antigiardial activity with similar IC 50 value (7.6 lg/cm 3 ) as compared to the reference drug metronidazole (IC 50 = 7.4 lg/cm 3 ). Similarly, several of the new compounds exhibited significant antitrichomonal activity and found to be more active than metronidazole with IC 50 ranging from 6.7 to 8.65 lg/cm 3 as compared to the reference drug metronidazole (8.9 lg/cm 3 ).

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Plants traditionally used individually and in combination to treat sexually transmitted infections in northern Maputaland, South Africa: Antimicrobial activity and cytotoxicity

Cited by 74 publications

References 126 publications

A comparative study of polyherbal Unani formulations in gestational Urinary tract infections

A comparative study of polyherbal Unani formulations in gestational Urinary tract infections

The synthesis of novel hybrid compounds containing 5-nitrothiazole moiety as potential antiparasitic agents

Synthesis, characterization, and biological activity of novel metronidazole-piperazine amides

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