Plaqueta e leptina em adolescentes com obesidade

Abstract

Objective: To analyze the influence of obesity status on immune cell count and concentration of the hormones cortisol and leptin, in order to establish a relationship among the variables analyzed. Methods:We recruited 27 obese [body mass index (BMI) ≥ 95th percentile] and 21 non-obese (BMI ≤ 75th percentile) adolescent boys and girls, aged 15-19 years at the post-pubertal stage. BMI was calculated as body weight divided by height squared, and body composition was estimated by plethysmography in the Bod Pod TM system. Blood samples were collected to analyze leukocytes, neutrophils, lymphocytes, monocytes, platelets, cortisol, and leptin.The Kolmogorov-Smirnov test was performed, followed by the independent Student t test in case of normal distribution.Significance values were set at p < 0.05 and expressed as means ± standard deviation. The statistical package SPSS for Windows version 12.0 was used.Results: There was no difference between obese and non-obese adolescents in terms of leukocyte, neutrophil, lymphocyte, monocyte and cortisol serum concentrations. The group of obese adolescents presented higher platelet and leptin concentrations (p < 0.01). The prevalence of hyperleptinemia was 25.92% in the obese adolescents (15.38% in boys and 35.7% in girls). Conclusions:Obese adolescents have higher platelet and leptin concentrations in comparison with non-obese adolescents. It was also found that obese girls presented a higher prevalence of hyperleptinemia than obese boys.

Circulating CD36 and oxLDL levels are associated with cardiovascular risk factors in young subjects

“…In addition, research has shown that adults and children with obesity have higher levels of leukocytes, mainly monocytes, compared with adults and children of normal weight [32-34]. Regarding increased platelet count in subjects with obesity, similar findings have been shown in other studies, where the platelet count is higher in teenagers and adults with obesity than normal weight subjects [35,36]. In relation to cytokines, it has been shown that interleukin-6 (IL-6) induces differentiation of megakaryocytes into platelets and that IL-6 is produced by adipose tissue [37,38].…”

Relationship between lipid and hematological profiles with adiposity in obese adolescents

“…An estimation of fat depots are essential to better understand the effects of obesity on the health status, as fat distribution has been described as an important marker of inflammation and is directly linked to changes in cytokine concentrations and the platelet count ( 8 ) . Additionally, platelets, red blood cells (RBCs) and hemoglobin are associated with cardiorespiratory conditions ( 9 , 10 ) , the oxidative metabolism ( 11 ) , and cardiovascular events ( 12 ) in obese and non-obese individuals.…”

Nutritional status, metabolic changes and white blood cells in adolescents

“…Foschini et al ,26 when assessing 48 adolescents, 27 obese and 21 non-obese according to BMI, also reported no differences regarding the concentrations of leukocytes, neutrophils, lymphocytes, and monocytes. However, Zaldivar et al 3 have shown that obese children have a higher concentration of circulating leukocytes, particularly neutrophils, monocytes, and lymphocytes.…”

“…Foschini et al ,26 ao avaliarem 48 adolescentes, sendo 27 obesos e 21 não obesos segundo o IMC, também não relataram diferença com relação às concentrações de leucócitos, neutrófilos, linfócitos e monócitos. Por outro lado Zaldivar et al ,3 demonstraram que crianças obesas apresentam maior concentração de leucócitos circulantes, em particular, neutrófilos, monócitos e linfócitos.…”