Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Norris, Jill M.; Lee, Hye Seung; Frederiksen, Brittni N.; Erlund, Iris; Uusitalo, Ulla; Yang, Jimin; Lernmark, Åke; Simell, Olli; Toppari, Jorma; Rewers, Marian; Ziegler, Anette G.; She, Jin Xiong; Önengüt-Gümüşcü, Suna; Chen, Wei Min; Rich, Stephen S.; Sundvall, Jouko; Akolkar, Beena; Krischer, Jeffrey P.; Virtanen, Suvi Μ.; Hagopian, William

doi:10.2337/db17-0802

Cited by 85 publications

(96 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TEDDY study group has recently confirmed that higher plasma 25‐hydroxyvitamin D correlates with lower risk for islet autoimmunity in children with genetic susceptibility to T1D (odds ratio = 0.93 for a 5 nmol/L difference). This association is modified by rs7975232 of VDR gene as the protective effect of 25(OH) D was only seen in those with the minor allele of the SNP (odds ratio = 1.00, 0.92, and 0.86 for 0, 1, and 2 copies of minor allele respectively). In light of this latest finding from TEDDY, supplementation of dairy products with exogenous vitamin D might to a certain degree account for the stabilization of T1D incidence in Finland …”

Section: Environmental Determinantsmentioning

confidence: 97%

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Xia

Xie

Huang

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

A wealth of epidemiological studies concerning the distribution of type 1 diabetes (T1D) around the world have pointed to the appreciable variation in the incidence of T1D among disparate age groups, ethnicities, and geographical locations. On the whole, the incidence of childhood T1D has been on the rise, and a plausible inverse relationship between the initial incidence rate and the following annual increase in incidence has been raised. Countries that used to exhibit lower incidences tend to have steep annual increase whereas those with already-established high incidences are more likely to show a modest increase or even stabilization in T1D incidence. Environmental agents considered responsible for the current evolving pattern of T1D incidence will be detailed, mainly including the increasing prevalence of childhood obesity, viral infections in a chronic manner, maternal-child interaction such as breastfeeding, and latitude-ultraviolet B-vitamin D pathway. Certain rationale has been put forward in an attempt to explain the potential association between environmental agents and development of T1D. For instance, accelerator hypothesis regards insulin resistance as the promoter of earlier disease onset in obese children whereas the negative correlation of microbial infections in background populations with incidence of T1D represents the basic component of the hygiene hypothesis. Further investigations are still warranted to verify these theories across multiple ethnic groups and to identify additional contributors to the variation in T1D incidence.

show abstract

Section: Environmental Determinantsmentioning

confidence: 97%

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Xia

Xie

Huang

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…There have been varied results when studying children as opposed to in utero (maternal) exposure. TEDDY study (with European and US children) has shown a relationship between child vitamin D levels and risk of IA . A US cohort has shown an association between child n‐3 FA intake from food, n‐3 FAs in the erythrocyte membrane, and a reduced risk of IA but no association with progression from IA to T1D .…”

Section: Discussionmentioning

confidence: 99%

“…TEDDY study (with European and US children) has shown a relationship between child vitamin D levels and risk of IA. 5 A US cohort has shown an association between child n-3 FA intake from food, n-3 FAs in the erythrocyte membrane, and a reduced risk of IA 31 but no association with progression from IA to T1D. 32 According to these studies, the benefit of n-3 FA may be in the inhibition of IA seroconversion.…”

Section: Discussionmentioning

confidence: 99%

“…A meta‐analysis of five European case‐control studies concluded that vitamin D supplementation in infancy did offer protection against type 1 diabetes compared to no supplementation . The Environmental Determinants of Diabetes in the Young (TEDDY) Study found higher plasma vitamin D associated with a decreased risk of IA, primarily in children carrying a specific variant of the vitamin D receptor (VDR) gene …”

Section: Introductionmentioning

confidence: 99%

“…4 The Environmental Determinants of Diabetes in the Young (TEDDY) Study found higher plasma vitamin D associated with a decreased risk of IA, primarily in children carrying a specific variant of the vitamin D receptor (VDR) gene. 5 Sufficient maternal vitamin D status, influenced by both food and supplement intake, is necessary for neonates to be born with adultnormal 25(OH)D concentrations 6 and may affect an infant's risk for an autoimmune response. The All Babies in Southeast Sweden (ABIS) Study in Sweden found Vitamin D supplement use by pregnant mothers did reduce risk for IA in offspring at 1 year of age, but had no effect on IA at 2.5 years of age 7 and later reported no association between maternal supplementation and T1D in offspring.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study

et al. 2018

Self Cite

View full text Add to dashboard Cite

Objective We investigated the association between maternal use of vitamin D and omega‐3 fatty acids (n‐3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n‐3 FAs were analyzed as continuous or binary variables. We applied time‐to‐event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen‐DR‐DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n‐3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n‐3 FA supplementation during pregnancy.

show abstract

Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017

Lawrence

Divers

Isom

et al. 2021

JAMA

382

203

View full text Add to dashboard Cite

IMPORTANCEChanges in the prevalence of youth-onset diabetes have previously been observed.OBJECTIVE To estimate changes in prevalence of type 1 and type 2 diabetes in youths in the US from 2001 to 2017. DESIGN, SETTING, AND PARTICIPANTSIn this cross-sectional observational study, individuals younger than 20 years with physician-diagnosed diabetes were enumerated from 6 areas in the US (4 geographic areas, 1 health plan, and select American Indian reservations) for 2001, 2009, and 2017. EXPOSURES Calendar year. MAIN OUTCOMES AND MEASURES Estimated prevalence of physician-diagnosed type 1 and type 2 diabetes overall and by race and ethnicity, age, and sex. RESULTS Among youths 19 years or younger, 4958 of 3.35 million had type 1 diabetes in 2001, 6672 of 3.46 million had type 1 diabetes in 2009, and 7759 of 3.61 million had type 1 diabetes in 2017; among those aged 10 to 19 years, 588 of 1.73 million had type 2 diabetes in 2001, 814 of 1.85 million had type 2 diabetes in 2009, and 1230 of 1.85 million had type 2 diabetes in 2017. The estimated type 1 diabetes prevalence per 1000 youths for those 19 years or younger increased significantly from 1.48 (95% CI, 1.44-1.52) in 2001 to 1.93 (95% CI, 1.88-1.98) in 2009 to 2.15 (95% CI, 2.10-2.20) in 2017, an absolute increase of 0.67 per 1000 youths (95%, CI, 0.64-0.70) and a 45.1% (95% CI, 40.0%-50.4%) relative increase over 16 years. The greatest absolute increases were observed among non-Hispanic White (0.93 per 1000 youths [95% CI, 0.88-0.98]) and non-Hispanic Black (0.89 per 1000 youths [95% CI, 0.88-0.98]) youths. The estimated type 2 diabetes prevalence per 1000 youths aged 10 to 19 years increased significantly from 0.34 (95% CI, 0.31-0.37) in 2001 to 0.46 (95% CI, 0.43-0.49) in 2009 to 0.67 (95% CI, 0.63-0.70) in 2017, an absolute increase of 0.32 per 1000 youths (95% CI, 0.30-0.35) and a 95.3% (95% CI, 77.0%-115.4%) relative increase over 16 years. The greatest absolute increases were observed among non-Hispanic Black (0.85 per 1000 youths [95% CI, 0.74-0.97]) and Hispanic (0.57 per 1000 youths [95% CI, 0.51-0.64]) youths. CONCLUSIONS AND RELEVANCEIn 6 areas of the US from 2001 to 2017, the estimated prevalence of diabetes among children and adolescents increased for both type 1 and type 2 diabetes.

show abstract

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Cited by 85 publications

References 55 publications

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study

Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017

Contact Info

Product

Resources

About