Plasma 25-hydroxyvitamin D concentrations are inversely associated with blood pressure of Dahl salt-sensitive rats

Thierry-Palmer, Myrtle; Carlyle, Kemia S.; Williams, Monet D.; Tewolde, Teclemicael K.; Caines-McKenzie, Sheres; Bayorh, Mohamed A.; Emmett, Nerimiah; Harris‐Hooker, Sandra; Sanford, Gary L.; Williams, Evan F.

doi:10.1016/s0960-0760(98)00037-5

Cited by 27 publications

(31 citation statements)

References 31 publications

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“…Data acquired through a number of different experimental and clinical studies indicate that VD also plays an important role in cardiovascular homeostasis. 25-Hydroxyvitamin D levels are inversely related to BP levels in selected forms of rodent (35) and human (36) hypertension, and administration of VD restores BP to normal or near-normal levels (37,38). Of note, the recent study of Teng et al (39) demonstrated improved survival of patients who had ESRD and were on hemodialysis when they were treated with the nonhypercalcemic analogue of VD, paricalcitol, versus VD itself, suggesting the existence of important salutary effects of the seco-steroid that are independent of its calcitropic properties.…”

Section: Discussionmentioning

confidence: 99%

“…Two microliters of 35 S-labeled VDR (synthesized in vitro) was incubated, in the presence of 2 l of unlabeled hRXR␣ and 0.5 g poly(dIdC), with 20 ng of unlabeled, double-stranded DR3 or NPR-A oligonucleotides and 10 nM VD. Reactions were carried out in binding buffer (10 mM NaHPO 4 [pH 7.6], 0.25 mM EDTA, 0.5 mM MgCl 2 , and 5% glycerol) for 20 min at 23°C.…”

Section: Protocolmentioning

confidence: 99%

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1,25 Dihydroxyvitamin D Amplifies Type A Natriuretic Peptide Receptor Expression and Activity in Target Cells

Chen

Ni²,

Humphreys³

et al. 2005

Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 99%

Section: Protocolmentioning

confidence: 99%

1,25 Dihydroxyvitamin D Amplifies Type A Natriuretic Peptide Receptor Expression and Activity in Target Cells

Chen

Ni²,

Humphreys³

et al. 2005

Journal of the American Society of Nephrology

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“…causes significant decreases in plasma 25-OHD concentration of salt-sensitive rats [3][4][5][6][7]. Blood pressure was shown to be directly correlated and plasma 25-OHD concentration indirectly correlated with the number of days that young salt-sensitive rats were fed an 8% salt diet [3,6] and an inverse correlation was demonstrated between blood pressure and plasma 25-OHD concentration [3,6,7]. A high salt diet, however, had no significant effect on blood pressure or plasma 25-OHD concentration of young salt-resistant rats.…”

Section: Introductionmentioning

confidence: 95%

“…The Dahl salt-sensitive rat is a widely studied genetic model of hypertension [1][2] that develops hypertension, renal hypertrophy, and hypovitaminosis D when fed a high salt diet [1][2][3][4][5][6][7]. Plasma 25-hydroxyvitamin D (25-OHD) concentration is an indicator of vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

High dietary cholecalciferol increases plasma 25-hydroxycholecalciferol concentration, but does not attenuate the hypertension of Dahl salt-sensitive rats fed a high salt diet

Thierry-Palmer

Cephas

Muttardy

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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The Dahl salt-sensitive rat, a model for salt-induced hypertension, develops hypovitaminosis D during high salt intake, which is caused by loss of protein-bound vitamin D metabolites into urine. We tested the hypothesis that high dietary cholecalciferol (5-and 10-fold standard) would increase plasma 25-hydroxycholecalciferol (25-OHD 3 ) concentration (indicator of vitamin D status) of saltsensitive rats during high salt intake. Salt-sensitive rats were fed 0.3% salt (low salt, LS), 3% salt (high salt, HS), 3% salt and 7.5 μg cholecalciferol/d (HS-D5), or 3% salt and 15 μg cholecalciferol/ d (HS-D10) and sacrificed at week 4. Plasma 25-OHD 3 concentrations of the two groups of HS-D rats were similar to that of LS rats and more than twice that of HS rats. Urinary cholecalciferol metabolite content of HS-D rats was more than seven times that of HS rats. Systolic blood pressures of the hypertensive HS and HS-D rats did not significantly differ, whereas LS rats were not hypertensive. We conclude that high dietary cholecalciferol increases plasma 25-OHD 3 concentration, but does not attenuate the hypertension of salt-sensitive rats during high salt intake. Low salt intake may be necessary to both maintain optimal vitamin D status and prevent hypertension in salt-sensitive individuals.

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“…Resnick et al (12) found 1,25(OH)2D3 to be inversely associated with plasma renin activity in human subjects with essential hypertension demonstrating a similar relationship that has been observed in the VDR knockout mouse model (13). Plasma 25(OH)D3 is also inversely associated with BP in the Dahl salt-sensitive strain of rat, a condition similar to the salt-sensitive hypertension seen in African Americans (44).…”

Section: Vitamin D Calcium Homeostasis and Parathyroid Hormonementioning

confidence: 67%

Vitamin D, Blood Pressure, and African Americans

Rostand¹

2010

Clinical Journal of the American Society of Nephrology

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Vitamin D deficiency has increasingly been recognized in the general population and especially in African Americans whose deep skin pigmentation makes vitamin D photosynthesis inefficient. Over the last decade there has been increasing interest in the role that vitamin D deficiency may play in BP modulation because many epidemiologic studies have shown an inverse association between serum vitamin D concentration and BP. There is a high prevalence of vitamin D deficiency in African Americans who also have an increased susceptibility to develop hypertension and its consequences. This paper will review the circumstances leading to vitamin D deficiency in the African American population and will also discuss how vitamin D deficiency can affect the renin-angiotensin system, free radical production, inflammatory processes, and carbohydrate tolerance that in turn influence vascular endothelial function and vascular structure producing increased vascular resistance. It will speculate that the presence of vitamin D deficiency throughout life from its earliest phases may adversely affect the microvasculature in African Americans, thereby playing a major role in the genesis and maintenance of hypertension.

show abstract

Plasma 25-hydroxyvitamin D concentrations are inversely associated with blood pressure of Dahl salt-sensitive rats

Cited by 27 publications

References 31 publications

1,25 Dihydroxyvitamin D Amplifies Type A Natriuretic Peptide Receptor Expression and Activity in Target Cells

1,25 Dihydroxyvitamin D Amplifies Type A Natriuretic Peptide Receptor Expression and Activity in Target Cells

High dietary cholecalciferol increases plasma 25-hydroxycholecalciferol concentration, but does not attenuate the hypertension of Dahl salt-sensitive rats fed a high salt diet

Vitamin D, Blood Pressure, and African Americans

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