Plasma ADH Level in Patients with Chronic Congestive Heart Failure

The Mechanism of Adaptation of Left Atrial Stretch Receptors in Dogs with Chronic Congestive Heart Failure

“…A loss of the end arborization was the most typical finding. It is concluded that chronic CHF brought about by an aorto-caval fistula results in a depressed left atrial stretch receptor response and that both decreased left atrial compliance and A preliminary report of the present investigation was presented at the 49th Scientific Session of the American Heart Association, [15][16][17][18] November 1976, Miami Beach, Fla.…”

“…The etiology of the altered fluid balance in CHF can be attributed to both hemodynamic (1,3,5,7) and hormonal factors (4,(8)(9)(10)(11). Evidence has been presented by several investigators that the secretion of antidiuretic hormone (ADH) may be altered during CHF or related disease states (12)(13)(14)(15)(16)(17)(18)(19).…”

“…In addition to the modulation of ADH secretion, enhanced left atrial stretch receptor activity has been shown to depress renal efferent sympathetic nerve activity (55,56), an effect that would increase renal blood flow and glomerular filtration rate, thereby enhancing the ability of the kidney to reduce plasma volume. In spite of the potent stimulus on left atrial stretch receptors in CHF, ADH titers remain high and renal blood flow remains low (12,(14)(15)(16)(17)(18)(19).…”

Static and dynamic responses of carotid sinus baroreceptors in dogs with chronic volume overload.

“…Increased sympathetic tone (Rutenberg & Spann, 1976;Chidsey, Braunwald & Morrow, 1965) and elevated plasma antidiuretic hormone (ADH) levels (Stein, Schwartz & Mirsky, 1954;Yamane, 1968;Zucker, Share & Gilmore, 1979) have been observed in heart failure. The chronic increase in vascular smooth muscle tone that is produced by these stimuli may play a role in the decreased baroreflex sensitivity seen in heart failure.…”

Differential Regulation of Plasma Copeptin Levels in Patients with Heart Failure: A Single-Center Prospective Study

“…Importantly, elevated plasma AVP has been reported in patients with HF (Yamane 1968;Francis et al 1990;Nakamura et al 2006), and an advanced assay system for C-terminal pro-AVP (copeptin), a vasopressin surrogate that is more stable and easier to measure than AVP, was developed over the past decade (Morgenthaler et al 2006). Importantly, copeptin was shown as an independent prognostic marker of cardiovascular diseases in large, prospective clinical studies (Morgenthaler 2010;Balling and Gustafsson 2014).…”