Plasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure

Abstract

PurposePlasma adiponectin concentrations are inversely related with metabolic syndrome (MetS), and MetS is associated with increased risk for heart failure (HF). However, the relationship between adiponectin and MetS in HF remains undetermined. Therefore, we tested whether MetS was associated with the degree of plasma adiponectin concentrations in HF patients.Materials and MethodsOne hundred twenty eight ambulatory HF patients with left ventricular ejection fraction of <50% (80 males, 61.8±11.9 years old) were enrolled for this cross-sectional study. Echocardiographic measurements were performed, and plasma concentrations of adiponectin, lipoproteins, apolipoproteins (apoB, apoA1) and high sensitive C-reactive protein (hsCRP) were measured.ResultsAdiponectin concentrations in HF patients with MetS (n=43) were significantly lower than those without MetS (n=85) (9.7±7.0 vs. 15.8±10.9 µg/mL, p=0.001). Higher concentrations of apoB (p=0.017), apoB/A1 ratio (p<0.001), blood urea nitrogen (p=0.034), creatinine (p=0.003), and fasting insulin (p=0.004) were observed in HF patients with MetS compared with those without MetS. In HF patients with MetS, adiponectin concentrations were negatively correlated with hsCRP (r=-0.388, p=0.015) and positively correlated with the ratio of early mitral inflow velocity to early diastolic mitral annular velocity, E/E' (r=0.399, p=0.015). There was a significant trend towards decreased adiponectin concentrations with an increasing number of components of MetS (p for trend=0.012).ConclusionOur study demonstrated that adiponectin concentrations decreased in HF patients with MetS, and that relationship between adiponectin, inflammation and abnormal diastolic function, possibly leading to the progression of HF.

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

“…39 This obesity-induced downregulated expression has been linked to the pathogenesis of various diseases. [40][41][42][43] In this study, for the first time, we demonstrated in vivo that lycopene was able to increase adiponectin mRNA levels in diet-induced obesity (Figure 1(b)), independent of the adiposity index in the rats ( Table 1). The increase in mRNA levels by lycopene was accompanied by an increase in plasma concentration of adiponectin (Figure 1(a)), indicating that the increase in adiponectin plasma concentration could be due an increased adiponectin mRNA synthesis in the adipose tissue.…”

Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort

“…Total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglycerides, and glucose levels were measured from blood samples obtained after a 12-hour fast. hsCRP was measured as previously described 11. Smoking was defined as current or former smoker.…”

Visceral Fat Area and Serum Adiponectin Level Predict the Development of Metabolic Syndrome in a Community-Based Asymptomatic Population

“…Adipokines, such as adiponectin, are secreted by the adipose tissue or as a result of glucose and lipid metabolism. [20–22]. Accordingly, the level of adiponectin is associated with obesity-related disorders and metabolic risk factors [23–26].…”