Plasma Adiponectin in Patients with Active, Early, and Chronic Rheumatoid Arthritis Who Are Steroid- and Disease-Modifying Antirheumatic Drug-Naive Compared with Patients with Osteoarthritis and Controls

Laurberg, Trine Bay; Frystyk, Jan; Ellingsen, Torkell; Hansen, Ib Tønder; Jørgensen, Anette; Tarp, Ulrik; Hetland, Merete Lund; Hørslev‐Petersen, Kim; Hornung, Nete; Poulsen, Jørgen; Flyvbjerg, Allan; Stengaard‐Pedersen, Kristian

doi:10.3899/jrheum.080907

Cited by 93 publications

(73 citation statements)

References 40 publications

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“…Clinically, adiposity is also associated with tendinopathy (42), and adipokines, such as leptin and adiponectin, have been associated with OA (43,44). Furthermore, another adipokine (visfatin) has been found to be associated with upper-extremity pain intensity (21) and with predicting recovery following upper-extremity injury.…”

Section: Discussionmentioning

confidence: 99%

Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort

Walsh

Gill

Evans

et al. 2016

Arthritis Care & Research

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Objective. To determine, first, if fat mass index (FMI) or fat-free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin-6 (IL-6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain. Methods. A subset of participants ages ‡50 years (n 5 1,462) from the North West Adelaide Health Study were used for this study. Participants from this community cohort were asked in stage 2 (2004)(2005)(2006) and stage 3 (2008-2010) if they had foot pain, aching, or stiffness. In stage 2, serum adipokines and anthropometry were measured, while body composition was analyzed with dual x-ray absorptiometry. These variables, along with comorbidities and social history, were used in logistic regression analyses to determine if FMI, FFMI, and serum adipokines were associated with foot pain. Results. Prevalent foot pain was present in 20.2% of participants, and future foot pain in 36.4%. Following multivariate modeling, the odds of having pain at stage 2 increased by 8% for each FMI unit (odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.04-1.12), while the odds of having pain at stage 3 increased by 6% for each FMI unit at stage 2 (OR 1.06, 95% CI 1.02-1.11). TNF level, IL-6 level, and FFMI were not associated with pain. Conclusion. Increased FMI, but not body mass index, FFMI, or TNF or IL-6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort

Walsh

Gill

Evans

et al. 2016

Arthritis Care & Research

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“…Adiponectin has been found to be higher in RA patients than in healthy controls (34,(77)(78)(79)(80)(81). Moreover, adiponectin levels are increased in early RA patients that had never taken disease-modifying antirheumatic drugs and in chronic RA patients (82). Circulating adiponectin levels correlate with the severity of RA evaluated by joint destruction and radiographic damage (83,84).…”

Section: Adiponectin and Rheumatic Diseasesmentioning

confidence: 99%

“…In patients with chronic RA, Laurberg et al reported that methotrexate increases adiponectin levels (82). However, in anti-TNF therapy of RA patients, different authors reported contradictory results: unchanged adiponectin levels (37,86,87), increased levels (88 -91), and decreased levels in combination with corticoids (92).…”

Section: Adiponectin and Rheumatic Diseasesmentioning

confidence: 99%

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Cardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines

Lago¹,

Gómez²,

Conde³

et al. 2011

Arthritis Care & Research

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“…The pathogenic role of adiponectin is largely unknown in concern to RA and OA. Recent data proved that in chronic RA patients adiponectin plasma levels are higher compared to healthy controls, but lower plasma levels than in OA (Laurberg et al, 2009). Another member of this group is resistin (FIZZ3) which is found in adipocytes, macrophages and other cell types.…”

Section: Adipokines As Potential Participants In Oamentioning

confidence: 99%