Plasma Adiponectin Levels Are Associated With Coronary Lesion Complexity in Men With Coronary Artery Disease

Otsuka, Fumiyuki; Sugiyama, Seigo; Kojima, Sunao; Maruyoshi, Hidetomo; Funahashi, Tohru; Matsui, Kunihiko; Sakamoto, Tomohiro; Yoshimura, Michihiro; Kimura, Kazuo; Umemura, Satoshi; Ogawa, Hisao

doi:10.1016/j.jacc.2006.05.054

Cited by 141 publications

(91 citation statements)

References 41 publications

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“…Furthermore, in a study of Japanese men with CAD, patients with acute coronary syndrome had lower adiponectin levels than stable CAD patients, whereas patients with multiple complex lesions had significantly lower adiponectin levels than those with solitary complex lesions. 13 Thus, low adiponectin levels may be related to vulnerability to coronary atherosclerosis, which was also confirmed by the results of the present study. An important new finding of the present study is that adiponectin levels were monitored in a cohort and cardiovascular events were assessed prospectively.In our study, the low adiponectin level predicted cardiovascular events but not cerebrovascular events.…”

Section: Discussionsupporting

confidence: 89%

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

et al. 2012

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As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin in the Japanese Arita-cho cohort study.We followed about 2000 subjects in Arita-cho, Saga, Japan as a cohort study, and we enrolled 637 subjects (205 men; 65.1 ± 8.3 years old) who participated in annual health checks from 2005 to 2008 and underwent measurement of the plasma adiponectin level and an oral glucose tolerance test. We monitored the incidence of cardiovascular or cerebrovascular events in these subjects until the end of 2010, discontinuing follow-up at 3 years after the start of enrollment. Subjects with low plasma adiponectin levels (o10.5 ng ml À1 ) had a higher incidence of newly diagnosed cardiovascular diseases such as acute heart failure or acute myocardial infarction than those with high plasma adiponectin levels (X10.5 ng ml À1 ) over an average of 2.95 years of follow-up. Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (b ¼ 0.16), male gender (b ¼ À0.267), homeostasis model assessment of insulin resistance (b ¼ À0.140) and the plasma levels of high-density lipoprotein cholesterol (b ¼ 0.104), uric acid (b ¼ À0.13), triglycerides (b ¼ À0.169) and brain natriuretic peptide (b ¼ 0.151). The difference in plasma glucose before and 120 min after the intake of a 75-g glucose load did not influence the plasma adiponectin level. The plasma adiponectin level is useful for predicting cardiovascular events, and is a measure of the risk of lifestyle-related diseases.

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Section: Discussionsupporting

confidence: 89%

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

et al. 2012

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“…In other studies, hypoadiponectinemia was observed to correlate with the prevalence or extent of CAD (11,12) and to serve as a risk factor for coronary heart disease (13,14). The aim of the present study, therefore, was to explore the relationship between serum adiponectin concentrations and the presence of the metabolic syndrome among patients with CAD.…”

Section: Adiponectin An Adipokine Now Recognized As a Key Regulator mentioning

confidence: 84%

Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Wang

Lee²,

Lee³

et al. 2010

Intern. Med.

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Objective Hypoadiponectemia was observed to correlate with the prevalence or extent of coronary artery disease (CAD) r=0.267; p=0.008) but were negatively correlated with triglyceride concentration (TG; p=0.013). Multivariate forward stepwise linear regression analysis of the significant variables revealed that HDL-cholesterol concentration (R square=0.071, p=0.008) and age (R square=0.039, p=0.044)

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“…Clinical studies showed that patients with CAD or immediately after acute coronary syndrome had decreased plasma adiponectin concentrations 8,28) . Otsuka et al indicated that plasma adiponectin levels were significantly associated with coronary lesion complexity in men with CAD, and suggested that hypoadiponectinemia may contribute to coronary plaque vulnerability 9) . Pischon and colleagues reported that high plasma adiponectin concentrations were associated with a lower risk of myocardial infarction among men without previous cardiovascular disease 15) ; however, Sattar and coworkers suggested that the relationship between adiponectin levels and CHD risk is comparatively moderate and requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with coronary artery disease (CAD) were shown to have decreased plasma adiponectin concentrations 8) . In addition, plasma adiponectin levels are significantly associated with the complexity of coronary lesions in men with CAD, suggesting that hypoadiponectinemia may contribute to coronary plaque vulnerability 9) ; however, there is uncertainty about the association between circulating concentrations of adiponectin and coronary heart disease (CHD) risk in patients after acute myocardial infarction (AMI).…”

Section: Introductionmentioning

confidence: 99%

Association of Adiponectin with Future Cardiovascular Events in Patients After Acute Myocardial Infarction

Huang

Chen

et al. 2010

JAT

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Aim:There is uncertainty about the association between circulating concentrations of adiponectin and coronary heart disease risk, particularly in patients after acute myocardial infarction (AMI). The goal of this study was to determine whether plasma adiponectin levels could predict future cardiovascular events in patients after AMI, and to elucidate the role of adiponectin in cardioprotection. Methods: A total of 102 patients with AMI were enrolled. Plasma adiponectin levels were examined from blood samples collected 18 months after AMI. All subjects were followed-up for 43 12 months. The primary endpoint was the combined occurrence of major adverse cardiovascular events (MACE), including rehospitalization due to unstable angina, nonfatal MI, revascularization with percutaneous coronary intervention or coronary artery bypass grafting, ischemic stroke, and cardiovascular death. Results: A total of 30 MACE occurred, including one case of cardiovascular death, five cases of nonfatal MI, and nine cases of ischemic stroke. Patients with MACE had lower plasma adiponectin levels (p 0.013). In addition, adiponectin was positively associated with changes in left ventricular ejection fraction (p 0.005). All patients were divided into a high-adiponectin group (≥ 6.46 g/mL) and a low-adiponectin group ( 6.46 g/mL). The incidence of MACE was significantly reduced in the high-adiponectin group (p 0.021). In multivariate Cox regression analysis that included adiponectin, classical risk factors, and medications, adiponectin was an independent predictor of MACE in patients after AMI (HR, 0.821; 95% CI, 0.691 to 0.974; p 0.024). Conclusions:The results indicate a potential association between plasma adiponectin levels and future cardiovascular events in patients after AMI. Moreover, plasma adiponectin concentrations appear to play a pivotal role in atherothrombosis and cardioprotection. J Atheroscler Thromb, 2010; 17:295-303.

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Plasma Adiponectin Levels Are Associated With Coronary Lesion Complexity in Men With Coronary Artery Disease

Abstract: Plasma adiponectin levels are significantly associated with coronary lesion complexity in men with CAD. Low adiponectin levels may contribute to coronary plaque vulnerability.

Cited by 141 publications

References 41 publications

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Association of Adiponectin with Future Cardiovascular Events in Patients After Acute Myocardial Infarction

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